Drug Studies on Rett Syndrome: From Bench to Bedside

Gomathi, Mohan; Padmapriya, S.; Vellingiri, Balachandar

doi:10.1007/s10803-020-04381-y

Cited by 43 publications

(32 citation statements)

References 135 publications

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“…Currently, COVID-19 has emerged as the most intense and petrifying viral infection to be handled by the human race. According to WHO (2020b), major concern among public health throughout the world and many countries have taken precautionary measures against the virus, and Government officials in all countries continue to make efforts to minimize human contact by facilitating countrywide shutdowns of public places as well as various steps have been initiated to ensure the safety of the people, like social distancing and self-quarantine which limits our social interactions (Balachandar et al, 2020). This will reduce the risk of spreading the COVID-19 to people by breaking the transmission chain and the influx of new COVID-19 cases in a given time period.…”

Section: Discussionmentioning

confidence: 99%

“…Indian traditional medicinal systems are considered as one of the oldest treatments in human history and it plays an important role in encountering global health care needs (Ravishankar and Shukla, 2007). Traditional Indian medicinal practices include Ayurveda, Siddha, Unani and Yoga, Naturopathy and Homoeopathy, which are successfully practiced for treating various diseases (Gomathi et al, 2020). These practices came into existence 5000 years ago, and these systems have been witnessed and scripted in ancient literature.…”

Section: Importance Of Indian Medicinementioning

confidence: 99%

“…But since then the virus has interactions. This will reduce the risk of spreading the COVID-19 to people by breaking the transmission chain and the influx of new COVID-19 cases in a given time period (Balachandar et al, 2020).…”

Section: Covid-19-the Global Challengesmentioning

confidence: 99%

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COVID-19: A promising cure for the global panic

Vellingiri

Jayaramayya

Iyer

et al. 2020

Science of The Total Environment

565

538

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Journal Pre-proof J o u r n a l P r e -p r o o f Acknowledgements: AbstractThe novel Coronavirus disease 2019 is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed.We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Importance Of Indian Medicinementioning

confidence: 99%

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COVID-19: A promising cure for the global panic

Vellingiri

Jayaramayya

Iyer

et al. 2020

Science of The Total Environment

565

538

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“…All the countries and pharma giants in the world are working to come out with either vaccines or drugs which will be helpful in containing this global pandemic. In India, attempts were made to address this problem through Ayurveda and Siddha practices as well apart from development of drugs and vaccines, which were still widely used among the Indian population to combat diseases caused by viral infections such as jaundice, malaria, cholera etc., (Gomathi et al, 2020). Ayurveda is the age old practice of treating human ailments in India and provided remedies against many medical conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Ayurveda is the age old practice of treating human ailments in India and provided remedies against many medical conditions. Medicinal herbs from India are promising in treating various illnesses (Gomathi et al, 2020). Further, identification of phytochemicals from medicinal plants can be used as drugs for viral infection targeting viral receptors (Chang and Woo, 2003;Keyaerts et al, 2007), viral integration (Kim et al, 2010), reverse transcription, viral replication and viral protein translation (Mansouri et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

In Silico Docking Analysis Revealed the Potential of Phytochemicals Present in Phyllanthus Amarus and Andrographis Paniculata, Used in Ayurveda Medicine in Inhibiting SARS-CoV-2

Hiremath¹,

D²,

Nandan³

et al. 2020

Preprint

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No therapeutics and vaccines are available against SARS-CoV-2 at present. In the current study we have made an attempt to provide preliminary evidences for interaction of 35 phytochemicals from two plants (Phyllanthus amarus and Andrographis paniculata used in Ayurveda) with SARS-CoV-2 proteins (S protein, 3CLpro, PLpro and RdRp) through in silico docking analysis. The docking was performed with the aid of AutoDock Vina and ADME and other pharmacokinetic properties were predicted using SWISSADME and admetSAR

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A Middle-aged Woman With Severe Scoliosis and Encephalopathy

2021

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A 42-year-old woman presented with clinical features of microcephaly, short stature, intellectual disability, severe degree of scoliosis, gait abnormality, and encephalopathy (Figure , A and B). She was born in 1973 at 38th week of gestation followed by a normal delivery (weight, 3.15 kg and head circumference, 42 cm) to nonconsanguineous parents. The head size was normal at birth, and no other abnormalities were seen during her infancy. At age 2 years, her parents noticed that she had delayed motor and language milestones. She experienced a progressive developmental delay such as reduction of head growth, loss of acquired communication, and loss of motor functions between ages 9 and 12 years. The severity of scoliosis increased withage,andshebecameawheelchairuseratage18years. She was referred to us at age 40 years with the characteristic features of growth deceleration (height, 142 cm; weight, 22 kg; body mass index, 11 [calculated as weight in kilograms divided by height in meters squared]), apraxia, left-sided hemiplegia, spasticity, sleep apnea, constipation, osteoporosis, hypoalgesia, and repetitive hand tapping (Video). Blood reports showed anemia (hemoglobin level of 9.1 g/dL; to convert to grams per liter, multiply by 10) and low levels of high-density lipoprotein cholesterol (47 mg/dL; to convert to millimoles per liter, multiply by 0.0259). There was no history of autistic behavior, vision or hearing impairments, or epilepsy. The electrocardiogram showed sinus rhythm with T wave inversion (V3-V6), and echocardiography showed mild cardiomegaly. The brain magnetic resonance imaging studies showed a diffuse reduction in the corpus callosum involving splenium and enlarged right ventricle, resulting in cerebral lateral ventricular asymmetry (Figure , C).

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Drug Studies on Rett Syndrome: From Bench to Bedside

Cited by 43 publications

References 135 publications

COVID-19: A promising cure for the global panic

COVID-19: A promising cure for the global panic

In Silico Docking Analysis Revealed the Potential of Phytochemicals Present in Phyllanthus Amarus and Andrographis Paniculata, Used in Ayurveda Medicine in Inhibiting SARS-CoV-2

A Middle-aged Woman With Severe Scoliosis and Encephalopathy

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