Drug-resistant tuberculosis: an experience from Qatar

Abstract

This study was conducted to evaluate the characteristics, treatment outcome and risk factors associated with 223 drug-resistant tuberculosis (DR-TB) cases in the State of Qatar. A descriptive records-based retrospective study was conducted on patients registered at Communicable Disease Centre (CDC), Qatar to all consecutive microbiologically confirmed tuberculosis cases for the period January 2010-March 2015. Demographic, clinical data, drug-resistance pattern of isolated mycobacteria and treatment outcome was assessed for the patient who completed their treatment in Qatar. Of 3301 patients with positive M. tuberculosis culture were analyzed; 223 (6.7%) were resistant to at least one drug. The overall prevalence of multi-d rug resistant TB (MDR-TB) was 1.2% (n = 38) of patients. A former resident of Indian sub contents was the most common demographic characteristic observed (64.1%). The outcome of treatment was assessed for 85 resistant cases with followup after completion of treatment. Cure and relapse rates were 97.6%, and 2.4%, respectively. Drug-resistant TB in Qatar is influenced by migration where the patients were probably infected. Rapid sputum sampling performed in the early stages of the disease, patient isolation, and drug-susceptibility testing should be the standard of care.

HIV and AIDS-defining opportunistic illnesses in the state of Qatar: A cohort population-based retrospective study covering 17 years (2000–2016)

“…We observed that none of the studied cases had MDR TB (multi-drug resistant Tuberculosis). This can be partially explained by the low overall prevalence of MDR TB in Qatar [ 14 ].…”

A Saudi Arabian Public Health Perspective of Tuberculosis

“…Complete success of MDR-TB treatment was attributed to strict adherence to Directly Observed Therapy (DOTs) for the entire time frame of treatment. However, the HIV and MDR-TB relation was not established, although the WHO recommends routine HIV testing as part of TB/HIV interventions offered to all TB patients [ 42 ]. The global TB report of 2016 gives a diverse burden with Kuwait leading the list with 200 million while UAE had 6.8 million and was at the bottom of the list.…”

Phenotypic Drug Resistance Pattern and Mutation Characteristics of Mycobacterium tuberculosis from Different Body Fluids Among Extra Pulmonary Patients Presented in Selected Hospitals in Addis Ababa, Ethiopia

“…Our finding was higher than the reports in Ghana (15.5%), Qatar (6.7%), and Addis Ababa (19.2%). [17][18][19] The magnitude of MDR-TB in our study (4.5%) was higher than that reported from Indonesia (0.8%) and Qatar (1.2%). 14,18 The higher MDR-TB rates in this study than in Indonesia and Qatar could be due to geographical and socioeconomic differences.…”