Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels

Valo, Hanna; Arola, Suvi; Laaksonen, Päivi; Torkkeli, Mika; Peltonen, Leena; Linder, Markus B.; Serimaa, Ritva; Kuga, Shigenori; Hirvonen, Jouni; Laaksonen, Timo

doi:10.1016/j.ejps.2013.02.023

Cited by 212 publications

(112 citation statements)

References 51 publications

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“…The DCNF aerogel showed controlled release behavior, with 69.205%±2.5% of the drug being released in 24 hours, while almost-complete drug release was seen within 12 hours from the drug solution. The dissolution behavior from the cellulose matrix is primarily dependent on the penetration of medium into the matrix and the swelling properties of the porous matrix formed after lyophilization, 12 in addition to the dissolution of the drug from the matrix.…”

Section: In Vitro Drug Release Studymentioning

confidence: 99%

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Bhandari¹,

Mishra²,

Mishra³

et al. 2017

IJN

141

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Cellulose nanofiber (CNF) aerogels with favorable floatability and mucoadhesive properties prepared by the freeze-drying method have been introduced as new possible carriers for oral controlled drug delivery system. Bendamustine hydrochloride is considered as the model drug. Drug loading was carried out by the physical adsorption method, and optimization of drug-loaded formulation was done using central composite design. A very lightweight-aerogel-with-matrix system was produced with drug loading of 18.98%±1.57%. The produced aerogel was characterized for morphology, tensile strength, swelling tendency in media with different pH values, floating behavior, mucoadhesive detachment force and drug release profiles under different pH conditions. The results showed that the type of matrix was porous and woven with excellent mechanical properties. The drug release was assessed by dialysis, which was fitted with suitable mathematical models. Approximately 69.205%±2.5% of the drug was released in 24 hours in medium of pH 1.2, whereas ~78%±2.28% of drug was released in medium of pH 7.4, with floating behavior for ~7.5 hours. The results of in vivo study showed a 3.25-fold increase in bioavailability. Thus, we concluded that CNF aerogels offer a great possibility for a gastroretentive drug delivery system with improved bioavailability.

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Section: In Vitro Drug Release Studymentioning

confidence: 99%

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Bhandari¹,

Mishra²,

Mishra³

et al. 2017

IJN

141

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“…An example of topical drug delivery using hydrophobins is formulation of the drug terbinafine which enhances the permeation of terbinafine through human nails (Vejnovic et al 2010b). Instead of directly coating drug nanoparticles, hydrophobins can also be used to modify the surface stability and biocompatibility of already existing drug-loaded particles of porous silicon (Bimbo et al 2011) and cellulose (Valo et al 2011(Valo et al , 2013.…”

Section: Dispersal Of Hydrophobic Solids Liquids and Airmentioning

confidence: 99%

Applications of hydrophobins: current state and perspectives

Wösten

Scholtmeijer

2015

Appl Microbiol Biotechnol

133

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Hydrophobins are proteins exclusively produced by filamentous fungi. They self-assemble at hydrophilichydrophobic interfaces into an amphipathic film. This protein film renders hydrophobic surfaces of gas bubbles, liquids, or solid materials wettable, while hydrophilic surfaces can be turned hydrophobic. These properties, among others, make hydrophobins of interest for medical and technical applications. For instance, hydrophobins can be used to disperse hydrophobic materials; to stabilize foam in food products; and to immobilize enzymes, peptides, antibodies, cells, and anorganic molecules on surfaces. At the same time, they may be used to prevent binding of molecules. Furthermore, hydrophobins have therapeutic value as immunomodulators and can been used to produce recombinant proteins.

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“…One approach included coating of drug nanoparticles with hydrophobic proteins and embedding them in hydrogels that were subsequently freeze-dried into aerogels [28].…”

Section: Enzymatic Production Of Nanocellulosementioning

confidence: 99%

Nanocellulose and Proteins: Exploiting Their Interactions for Production, Immobilization, and Synthesis of Biocompatible Materials

Fritz

Jeuck

Salas

et al. 2015

Advances in Polymer Science

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Nanocellulose has been used with promising results as reinforcement material in composites, many of which include hydrophobic polymers. However, the hydrophilic nature of nanocellulose can be better exploited in composites that incorporate high surface energy systems as well as in applications that can benefit from such properties. In fact, proteins can be ideal components in these cases. This paper reviews such aspects, which are based on the remarkable mechanical properties of nanocellulose. This material also exhibits low density, high aspect ratio, high surface area, and can be modified by substitution of its abundant hydroxyl groups. It also shows biocompatibility, low toxicity, and biodegradability. Convenient biotechnological methods for its production are of interest not only because of the possible reduction in processing energy but also because of positive environmental aspects. Thus, enzymatic treatments are favorable for effecting fiber deconstruction into nanocellulose. In addition to reviewing nanocellulose production by enzymatic routes, we discuss incorporation of enzyme activity to produce biodegradable systems for biomedical applications and food packaging. Related applications have distinctive features that take advantage of protein-cellulose interactions and the possibility of changing nanocellulose properties via enzymatic or protein treatments.

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Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels

Cited by 212 publications

References 51 publications

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Applications of hydrophobins: current state and perspectives

Nanocellulose and Proteins: Exploiting Their Interactions for Production, Immobilization, and Synthesis of Biocompatible Materials

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