Drug permeation through egg shell membranes.

Washitake, Mitsunori; Takashima, Yasuji; Tanaka, Shigeo; Anmo, Toshio; Tanaka, Ichiro

doi:10.1248/cpb.28.2855

Cited by 17 publications

(4 citation statements)

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“…Several different approaches were developed to study the penetration of molecules through SC like egg shell membranes (Washitake et al, 1980), or cellulose acetate membranes (Barry and El Eini, 1975). We used such a membrane placed directly on the surface of Columbia blood agar plates for growth and release of haemolytic molecules by T. mentagrophytes (Fig.…”

Section: Discussionmentioning

confidence: 99%

Isolation and characterization of a haemolysin from Trichophyton mentagrophytes

Schaufuss¹,

Müller²,

Valentin‐Weigand³

2007

Veterinary Microbiology

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Section: Discussionmentioning

confidence: 99%

Isolation and characterization of a haemolysin from Trichophyton mentagrophytes

Schaufuss¹,

Müller²,

Valentin‐Weigand³

2007

Veterinary Microbiology

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“…The drug concentration in the receptor fluid was measured spectrophotometrically in comparison to an acceptable blank. The experiment was conducted three times [32].…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Design and Characterization of Citronella Oil-Loaded Micro-Emulgel for the Treatment of Candida Albicans Infection

Singh,

Chauhan,

Gupta

et al. 2023

Gels

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The purpose of the current study was to prepare and evaluate a citronella oil-loaded microemulsion-based micro-emulgel for the treatment of Candida albicans. The primary objective was to use the skin to transfer hydrophobic medications into the bloodstream. The formulation included cinnamon oil as an antifungal oil and citronella oil as an active pharmaceutical ingredient, respectively. Tween 80 and PEG 200 were used as the surfactant and co-surfactant, respectively, to create phase diagrams. Carbopol 940, one of the frequently used polymers, was investigated for its ability to prepare gel formulations. The optimized (F3) batch contained the highest percentage (87.05 ± 0.03%) of drug content and, according to the statistics provided, had the highest drug release rate of around 87.05% within 4 h. The Korsmeyer–Peppas model with n value of 0.82, which is in the range 0.5–1, had the highest r2 value, indicating that release following non-Fickian/anomalous diffusion provided a better dimension for all of the formulations. The optimized (F3) formulation had stronger antifungal activity in comparison to other formulations. This leads to the conclusion that citronella oil can be made into a micro-emulgel, which may improve its release in aqueous systems while maintaining a high level of drug release at the target site.

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“…An interesting investigation used egg membrane which, like human stratum corneum, consists mainly of keratin. 62 By using 0.5M hydrochloric outer shell of the whole egg was dissolved which resulting in a membrane. Thereafter, the contents of the egg may be detached and the membrane washed and refrigerated or soaked in isopropyl myristate under vacuum to impregnate the keratin matrix.…”

Section: In-vitro Drug Release Studiesmentioning

confidence: 99%

Untitled

2016

IJPSR

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Emulgel systems are currently of attention to the pharmaceutical scientists because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules. These are either emulsion of water in oil type or oil in water, which is gelled by mixing it with a gelling agent. Incorporation of emulsion into gel makes it a dual control release system & also increases its stability. Due to lack of insoluble excipients and excess oily bases, it demonstrates better drug release as compared to other topical drug delivery system. Due to nongreasy because of the presence of gel phase which favors good patient compliance. In order to understand the potential of emulgel as delivery vehicles, this review gives an overview of the ideal properties, formation, and characterization of emulgels. The use of emulgel -based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions.

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Drug permeation through egg shell membranes.

Cited by 17 publications

References 0 publications

Isolation and characterization of a haemolysin from Trichophyton mentagrophytes

Isolation and characterization of a haemolysin from Trichophyton mentagrophytes

Design and Characterization of Citronella Oil-Loaded Micro-Emulgel for the Treatment of Candida Albicans Infection

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