Drug Loading and Release Behavior Depending on the Induced Porosity of Chitosan/Cellulose Multilayer Nanofilms

Park, Sohyeon; Choi, Daheui; Jeong, Hyejoong; Heo, Jiwoong; Hong, Jinkee

doi:10.1021/acs.molpharmaceut.7b00371

Cited by 51 publications

(50 citation statements)

References 64 publications

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“…In addition, CS/NQ14 membranes exhibit release profiles similar to CS/NQ1 /05TPP or CS/NQ14/01TPP possibly due to the fact that it was partially neutralized with ammonium hydroxide and that substance associated with NQ14 may have conferred a crosslinking characteristic, a fact observed during the course of the experiment. Thus, crosslinking effectively controls the drug diffusion from chitosan matrix and our results agree with those found by other authors [ 84 , 85 , 86 ].…”

Section: Resultssupporting

confidence: 93%

Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

et al. 2018

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The aim of this paper was to prepare, by the freeze-drying method, ionically crosslinked chitosan membranes with different contents of pentasodium tripolyphosphate (TPP) and loaded with 1,4-naphthoquinone (NQ14) drug, in order to evaluate how the physical crosslinking affects NQ14 release from chitosan membranes for cancer therapy application. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WAXD), scanning electron microscopy (SEM), swelling degree, and through in vitro drug release and cytotoxicity studies. According to the results, the molecular structure, porosity and hydrophilicity of the chitosan membranes were affected by TPP concentration and, consequently, the NQ14 drug release behavior from the membranes was also affected. The release of NQ14 from crosslinked chitosan membranes decreased when the cross-linker TPP quantity increased. Thus, depending on the TPP amount, the crosslinked chitosan membranes would be a potential delivery system to control the release of NQ14 for cancer therapy application. Lastly, the inhibitory potential of chitosan membranes ionically crosslinked with TPP and loaded with NQ14 against the B16F10 melanoma cell line was confirmed through in vitro cytotoxicity studies assessed via MTT assay. The anti-proliferative effect of prepared membranes was directly related to the amount of cross-linker and among all membranes prepared, such that one crosslinked with 0.3% of TPP may become a potential delivery system for releasing NQ14 drug for cancer therapy.

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Section: Resultssupporting

confidence: 93%

Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

et al. 2018

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“…In terms of film stability and structure, cross-linking may be the only reason the PEM can form; as aforementioned, Johnasson et al (2005) [ 46 ] observed the instability of HA/COL PEMs at physiological pH, where cross-linking with carbodiimide chemistry together with NHS resulted in their stabilisation. Carbodiimide chemistry has also been employed within HA/PLL capsule systems to enhance stability [ 187 ] and reduce shrinkage [ 188 ], as well as within CMC/CHI PEMs to increase the porosity of the films, which was proven to increase the loading and release efficacy of macromolecular drugs [ 189 ].…”

Section: Biopolymer Dynamics At the Macroscalementioning

confidence: 99%

Layer-By-Layer Assemblies of Biopolymers: Build-Up, Mechanical Stability and Molecular Dynamics

Campbell

Vikulina

2020

Polymers

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Rapid development of versatile layer-by-layer technology has resulted in important breakthroughs in the understanding of the nature of molecular interactions in multilayer assemblies made of polyelectrolytes. Nowadays, polyelectrolyte multilayers (PEM) are considered to be non-equilibrium and highly dynamic structures. High interest in biomedical applications of PEMs has attracted attention to PEMs made of biopolymers. Recent studies suggest that biopolymer dynamics determines the fate and the properties of such PEMs; however, deciphering, predicting and controlling the dynamics of polymers remains a challenge. This review brings together the up-to-date knowledge of the role of molecular dynamics in multilayers assembled from biopolymers. We discuss how molecular dynamics determines the properties of these PEMs from the nano to the macro scale, focusing on its role in PEM formation and non-enzymatic degradation. We summarize the factors allowing the control of molecular dynamics within PEMs, and therefore to tailor polymer multilayers on demand.

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“…The yield with which chitosan is extracted from the chrysalides is very low but the purity of the chitin isolated is very high. (Paulino et al, 2006)…”

Section: Silkworm Industriesmentioning

confidence: 99%

Biowastes as a source of extracting chitin and chitosan for biomedical applications

Yadav¹,

Yinaganti²,

Mairal³

et al. 2020

Recyc & Sust Dev

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Biomaterials are designed to interact with biological systems in aid to wound healing, regeneration of tissue, mechanical support, and drug delivery to eventually improve current therapeutic outcomes. The adoption of biomaterials is increasing constantly in health care practices by making it more biocompatible and non-toxic under physiological conditions. These adoptions have been associated with improvements in therapeutic outcomes across the population, however, the dosage of therapeutics needed to successfully treat a disease is generally different for each individual and relies a lot on experiences of consultant doctors. Many times, it leads to human errors in deciding on drug doses, un-fit implants and explants and eventually adverse effects or less positive effects. The personalized medicine and devices bring forth the idea that the medicine should be tailored for a patient based on various characteristics, such as gender, age, genetic makeup, and lifestyle. These personalized medicine approaches include type of drugs, activation methods, nanoassemblies, biomedical devices, etc. Among these approaches, personalized biomedical devices have become popular with the advent of 3D printing technologies, which can make customized implants for each patient with minimum price, limited time, and high accuracy. Personalized biomedicine also involves designing of drug to cater the need of an individual with minimum side effects. In this review an effort has been made to introduce different aspects of customized biomedical agents like therapeutic biomolecules, nanomedicine, implants, and explants. This comprehensive review of literature indicates that use of 3D printing technology in producing drug releasing, biodegradable personalized implants could be better therapeutic solution for a range of medical conditions.

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Drug Loading and Release Behavior Depending on the Induced Porosity of Chitosan/Cellulose Multilayer Nanofilms

Cited by 51 publications

References 64 publications

Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

Layer-By-Layer Assemblies of Biopolymers: Build-Up, Mechanical Stability and Molecular Dynamics

Biowastes as a source of extracting chitin and chitosan for biomedical applications

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