Drug-loaded nano-microcapsules delivery system mediated by ultrasound-targeted microbubble destruction: A promising therapy method

Ma, Jing; Du, Lian Fang; Chen, Ming; Wang, Hang Hui; Xing, Ling; Li, Jing; Li, Yun Hua

doi:10.3892/br.2013.110

Cited by 22 publications

(20 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultrasound microbubble-activation therapies have attractive features, including the ability to guide the treatment using ultrasound imaging, and real time feedback from the microbubble emissions (Cochran et al 2011; Kooiman et al 2014; Vignon et al 2013). Prospective treatments range from transient opening of capillaries, such as the blood brain barrier (Burgess and Hynynen, 2014), to complex methods for drug or gene delivery using specially prepared gaseous delivery vehicles that can be targeted to the desired region for treatment (Ma et al 2013). These methods have been studied for treatments such as gene therapy, cancer treatment, and thrombolysis (Laing and McPherson 2009; Ibsen et al 2013b; Unger et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Use of Theranostic Strategies in Myocardial Cavitation-Enabled Therapy

Miller

Dou

et al. 2015

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

The accumulation of microlesions induced by ultrasound interaction with contrast microbubbles in the myocardium potentially represents a new method of tissue reduction therapy. Anesthetized rats were treated in a heated water bath with 1.5 MHz focused ultrasound pulses triggered once every 4 heartbeats from the electrocardiogram (ECG) during infusion of microbubble contrast agent. Treatment was guided by an 8 MHz B-mode imaging transducer, which also was used to provide estimates of the left ventricular echogenicity (LVE) as a possible predictor of efficacy during treatment. Strategies to reduce prospective clinical treatment durations were tested, including pulse modulation to simulate a theranostic scanning strategy, and an increased agent infusion rate over shorter durations. Sources of variability, including ultrasound path variation and venous catheter placement, also were investigated. ECG premature complexes (PCs) were monitored and Evans-blue stained cardiomyocyte scores (SCSs) were obtained from frozen sections. The LVE reflected variations in the infused microbubble concentration, but failed to predict efficacy. Comparing suspensions of varied microbubble sizes revealed that LVE was dominated by larger bubbles, while efficacy appeared to be dependent on smaller sizes. Simulated scanning was as effective as the normal fixed-beam treatment, and high agent infusion allowed reduced treatment duration. The success of these theranostic strategies may increase the prospects for realistic clinical translation of myocardial cavitation enabled therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Use of Theranostic Strategies in Myocardial Cavitation-Enabled Therapy

Miller

Dou

et al. 2015

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…These findings suggested that local administration of cytotoxic agents with sonoporation is a useful method for molecular cancer therapy.The patient will be saved from adverse effects of anticancer drugs which usually act as double edged swords. 2,4 The confirmation of the delivery of compound into cells was made by using markers such as plasmid GFP. Some research focused on the study of sonoporation mechanisms in order to achieve optimal delivery outcome such as high delivery efficiency and minimal cell death.…”

Section: Review Of Literaturementioning

confidence: 99%

“…Although clinical treatment is generally accomplished with surgery in those cases, the prognosis is not particularly good and the use of antiproliferative agents, such as 5-fluorouracil, mitomycin C and BLM, has been reported to remarkably improve the therapeutic effect. 4 Sonoporation efficiency is also related to the microbubble concentration and composition, as well as to the microbubble to cell ratio. 5,14,15 Additional therapy guided with sonoporation dramatically inhibited primary tumour growth throughout the course of the disease, with median survival increases of up to 10% demonstrated in adenocarcinomas of pancreatic xenografts in comparison to the control groups.…”

Section: Other Application In Dentistrymentioning

confidence: 99%

See 1 more Smart Citation

Sonoporation - One of the promising techniques to treat oral cancer

2014

IJDA

View full text Add to dashboard Cite

Recent studies demonstrate that ultrasound can be used to deliver compounds into viable cells advantageous possibilities in the field of precancer and cancer management. The delivery is facilitated through ultrasound waves i.e. sonoporation, principle is the formation of temporary pores in the cell membrane induced by ultrasound. Our review focuses on the study of sonoporation mechanisms in order to achieve optimal delivery outcome such as high delivery efficiency and minimal cell death. Ultrasound increased the transmembrane current as a direct result of decreased membrane resistance due to pore formation. The ability to real time monitor sonoporation of cells provides a novel and necessary tool to study the dynamic sonoporation process and obtain optimal delivery parameters. We reviewed the literature so that we can make a clear sense to utilize the sonoporation in the field of cancer and precancer lesions of oral cavity.

show abstract

“…The microparticle system extends the drug circulation time in the body and improves the drug concentration in target tissues. This increases the therapeutic efficacy and reduces the frequency of drug administration (6).…”

Section: Introductionmentioning

confidence: 99%

Non-toxic agarose/gelatin-based microencapsulation system containing gallic acid for antifungal application

Lam

Gambari

Kok

et al. 2014

International Journal of Molecular Medicine

View full text Add to dashboard Cite

Abstract.Aspergillus niger (A. niger) is a common species of Aspergillus molds. Cutaneous aspergillosis usually occurs in skin sites near intravenous injection and approximately 6% of cutaneous aspergillosis cases which do not involve burn or HIV-infected patients are caused by A. niger. Biomaterials and biopharmaceuticals produced from microparticle-based drug delivery systems have received much attention as microencapsulated drugs offer an improvement in therapeutic efficacy due to better human absorption. The frequently used crosslinker, glutaraldehyde, in gelatin-based microencapsulation systems is considered harmful to human beings. In order to tackle the potential risks, agarose has become an alternative polymer to be used with gelatin as wall matrix materials of microcapsules. In the present study, we report the eco-friendly use of an agarose/gelatin-based microencapsulation system to enhance the antifungal activity of gallic acid and reduce its potential cytotoxic effects towards human skin keratinocytes. We used optimal parameter combinations, such as an agarose/gelatin ratio of 1:1, a polymer/oil ratio of 1:60, a surfactant volume of 1% w/w and a stirring speed of 900 rpm. The minimum inhibitory concentration of microencapsulated gallic acid (62.5 µg/ml) was significantly improved when compared with that of the original drug (>750 µg/ml). The anti-A. niger activity of gallic acid -containing microcapsules was much stronger than that of the original drug. Following 48 h of treatment, skin cell survival was approximately 90% with agarose/gelatin microcapsules containing gallic acid, whereas cell viability was only 25-35% with free gallic acid. Our results demonstrate that agarose/gelatin-based microcapsules containing gallic acid may prove to be helpful in the treatment of A. niger-induced skin infections near intravenous injection sites.

show abstract

Drug-loaded nano-microcapsules delivery system mediated by ultrasound-targeted microbubble destruction: A promising therapy method

Cited by 22 publications

References 47 publications

Use of Theranostic Strategies in Myocardial Cavitation-Enabled Therapy

Use of Theranostic Strategies in Myocardial Cavitation-Enabled Therapy

Sonoporation - One of the promising techniques to treat oral cancer

Non-toxic agarose/gelatin-based microencapsulation system containing gallic acid for antifungal application

Contact Info

Product

Resources

About