Sonoporation - One of the promising techniques to treat oral cancer

Abstract

Recent studies demonstrate that ultrasound can be used to deliver compounds into viable cells advantageous possibilities in the field of precancer and cancer management. The delivery is facilitated through ultrasound waves i.e. sonoporation, principle is the formation of temporary pores in the cell membrane induced by ultrasound. Our review focuses on the study of sonoporation mechanisms in order to achieve optimal delivery outcome such as high delivery efficiency and minimal cell death. Ultrasound increased the transmembrane current as a direct result of decreased membrane resistance due to pore formation. The ability to real time monitor sonoporation of cells provides a novel and necessary tool to study the dynamic sonoporation process and obtain optimal delivery parameters. We reviewed the literature so that we can make a clear sense to utilize the sonoporation in the field of cancer and precancer lesions of oral cavity.