Drug-loaded gold plasmonic nanoparticles for treatment of multidrug resistance in cancer

Lee, Sun Mi; Kim, Hyung Joon; Kim, Sook Young; Kwon, Min Soo; Kim, Sol; Cho, Arthur; Yun, Mijin; Shin, Jeon Soo; Yoo, Kyung Hwa

doi:10.1016/j.biomaterials.2013.11.068

Cited by 84 publications

(64 citation statements)

References 22 publications

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“…In the past decades, the application of AuNPs in drug delivery has gained much attention due to their unique properties, including convenient preparation procedure, well controlled particle size and easy functionalization [28,29]. There were many studies utilizing AuNPs for tumor targeting drug delivery and tumor diagnosis as well as overcoming multidrug resistance [30,31]. Thus in this study, AuNPs were used as carriers for DOX delivery.…”

Section: Introductionmentioning

confidence: 97%

Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles

et al. 2015

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Section: Introductionmentioning

confidence: 97%

Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles

et al. 2015

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“…Before FTIR measurements, all the samples were freeze dried. The ratio of the mass of antibody relative to the total mass of MSNs was evaluated based on the Bradford method using the Bio-Rad protein assay as previous report [34].…”

Section: Characterizationmentioning

confidence: 99%

CD44-engineered mesoporous silica nanoparticles for overcoming multidrug resistance in breast cancer

Wang

Liu

Wang

et al. 2015

Applied Surface Science

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“…Moreover, by combining PTT with chemotherapy, it could induce synergistic effects and eliminate MDR cancer cells more effectively. For instance, the DOX‐loaded‐poly(lactic‐co‐glycolic acid) hybrid gold nanoparticles functionalized with targeting moieties of anti‐death receptor‐4 monoclonal antibody ( Figure 5 A,B) were employed to treat MDR cancers by chemo‐photothermal therapy 108. These nanoparticles could increase the amount of drugs delivered to tumors and decrease the activity of P‐gp by heat generated from Au nanoparticles after laser irradiation.…”

Section: Inorganic Nanocarriers Overcoming Drug Resistance For Cancermentioning

confidence: 99%

Section: Inorganic Nanocarriers Overcoming Drug Resistance For Cancermentioning

confidence: 99%

Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics

et al. 2016

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Cancer multidrug resistance (MDR) could lead to therapeutic failure of chemotherapy and radiotherapy, and has become one of the main obstacles to successful cancer treatment. Some advanced drug delivery platforms, such as inorganic nanocarriers, demonstrate a high potential for cancer theranostic to overcome the cancer‐specific limitation of conventional low‐molecular‐weight anticancer agents and imaging probes. Specifically, it could achieve synergetic therapeutic effects, demonstrating stronger killing effects to MDR cancer cells by combining the inorganic nanocarriers with other treatment manners, such as RNA interference and thermal therapy. Moreover, the inorganic nanocarriers could provide imaging functions to help monitor treatment responses, e.g., drug resistance and therapeutic effects, as well as analyze the mechanism of MDR by molecular imaging modalities. In this review, the mechanisms involved in cancer MDR and recent advances of applying inorganic nanocarriers for MDR cancer imaging and therapy are summarized. The inorganic nanocarriers may circumvent cancer MDR for effective therapy and provide a way to track the therapeutic processes for real‐time molecular imaging, demonstrating high performance in studying the interaction of nanocarriers and MDR cancer cells/tissues in laboratory study and further shedding light on elaborate design of nanocarriers that could overcome MDR for clinical translation.

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Drug-loaded gold plasmonic nanoparticles for treatment of multidrug resistance in cancer

Cited by 84 publications

References 22 publications

Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles

Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles

CD44-engineered mesoporous silica nanoparticles for overcoming multidrug resistance in breast cancer

Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics

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