Drug Interactions with Agents Used in the Treatment of Cardiovascular Disease

Griffin, Jasper; D’Arcy, P. F.

doi:10.1016/b978-044482406-6/50008-3

Cited by 1 publication

(2 citation statements)

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“…Among the known oral anticoagulants, coumarin, warfarin, and indanone derivatives are well distributed. Their therapeutic action depends on their ability to suppress the formation of several functional factors of blood coagulation in the liver [ 1 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Drug-Delivery Silver Nanoparticles: A New Perspective for Phenindione as an Anticoagulant

Nikolova,

Milusheva,

Gledacheva

et al. 2023

Biomedicines

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Anticoagulants prevent the blood from developing the coagulation process, which is the primary cause of death in thromboembolic illnesses. Phenindione (PID) is a well-known anticoagulant that is rarely employed because it totally prevents coagulation, which can be a life-threatening complication. The goal of the current study is to synthesize drug-loaded Ag NPs to slow down the coagulation process. Methods: A rapid synthesis and stabilization of silver nanoparticles as drug-delivery systems for phenindione (PID) were applied for the first time. Results: Several methods are used to determine the size of the resulting Ag NPs. Additionally, the drug-release capabilities of Ag NPs were established. Density functional theory (DFT) calculations were performed for the first time to indicate the nature of the interaction between PID and nanostructures. DFT findings supported that galactose-loaded nanostructure could be a proper delivery system for phenindione. The drug-loaded Ag NPs were characterized in vitro for their antimicrobial, cytotoxic, and anticoagulant activities, and ex vivo for spasmolytic activity. The obtained data confirmed the drug-release experiments. Drug-loaded Ag NPs showed that prothrombin time (PT, sec) and activated partial thromboplastin time (APTT, sec) are approximately 1.5 times longer than the normal values, while PID itself stopped coagulation at all. This can make the PID-loaded Ag NPs better therapeutic anticoagulants. PID was compared to PID-loaded Ag NPs in antimicrobial, spasmolytic activity, and cytotoxicity. All the experiments confirmed the drug-release results.

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Section: Introductionmentioning

confidence: 99%

“…Clinically, warfarin is used to reduce the incidence of thromboembolism associated with prosthetic heart valves and atrial fibrillation. PID’s effects are comparable to those of warfarin, but it is no longer often used due to the risk of serious side effects [ 1 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%