Drug Interactions and the Cytochrome P-450 Enzymes

Carlston, John A.

doi:10.1089/pai.1995.9.123

Cited by 1 publication

(2 citation statements)

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“…Other promising isotope breath tests are those for determining in vivo cytochrome P-450 activity, for example the 13 C-erythromycin breath test for CYP3A4 and 13 C-caffeine for CYP1A2. These enzymes are involved in the metabolism of a large number of drugs and exogenous compounds (Fuhr and Rost 1994) but can vary at least ten-fold (Carlston 1995). In the future a patient's CYP-450 activity could allow for accurate drug prescription, optimized to the patient's need and identify individuals whose CYP-450 profile renders them susceptible to leukaemia or lung cancer (Carlston 1995).…”

Section: Use Ofmentioning

confidence: 99%

“…The carbon isotope breath test has an important role in diagnostic and investigative medicine. It has become well established in the treatment of Helicobacter pylori (Logan et al 1991) and has the potential of becoming a valuable tool to the prescribing physician when assessing a patient's drug requirement (Carlston 1995). The instrument conventionally used to measure the isotopic ratio of breath is an isotope ratio mass spectrometer (IRMS), a sensitive but expensive and complex instrument.…”

Section: Introductionmentioning

confidence: 99%

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The application of infrared spectroscopy to breath CO₂isotope ratio measurements and the risk of spurious results

Mansfield

Rutt

1998

Phys. Med. Biol.

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Stable CO2 isotope breath tests are established as a valuable tool in diagnostic and investigative medicine with the potential to become more prominent in the future. However, their development and widespread clinical use is limited by the requirement of isotope ratio mass spectroscopic analysis. To overcome this restriction alternative analytical techniques have been developed; the most promising, offering relative simplicity and lower costs, are those instruments using infrared spectroscopy. Clinical investigations using such instruments show them to perform well but very little attention has been given to the possibility of interference from the infrared absorption spectrum of other compounds in the breath. To provide an unambiguous answer to this concern we have analysed literature on over 200 detected breath compounds and their infrared absorption spectra to identify any absorption bands coincident with the nu3 absorption band of CO2. It was found that only five breath trace compounds possess coincident fundamental absorption bands, none of which pose the risk of spurious results. We conclude that the 13C16O2/12C16O2 ratio can confidently be measured for isotopic breath tests using an infrared spectrometer, the position of the nu3 absorption band of CO2 in the infrared spectrum precluding any discernible risk of spurious measurements due to coincidental absorption bands.

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Section: Use Ofmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The application of infrared spectroscopy to breath CO₂isotope ratio measurements and the risk of spurious results

Mansfield

Rutt

1998

Phys. Med. Biol.

View full text Add to dashboard Cite

show abstract

Drug Interactions and the Cytochrome P-450 Enzymes

Cited by 1 publication

References 33 publications

The application of infrared spectroscopy to breath CO₂isotope ratio measurements and the risk of spurious results

The application of infrared spectroscopy to breath CO₂isotope ratio measurements and the risk of spurious results

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Drug Interactions and the Cytochrome P-450 Enzymes

Cited by 1 publication

References 33 publications

The application of infrared spectroscopy to breath CO2isotope ratio measurements and the risk of spurious results

The application of infrared spectroscopy to breath CO2isotope ratio measurements and the risk of spurious results

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The application of infrared spectroscopy to breath CO₂isotope ratio measurements and the risk of spurious results

The application of infrared spectroscopy to breath CO₂isotope ratio measurements and the risk of spurious results