Drug intelligence based on MDMA tablets data

Weyermann, Céline; Marquis, Raymond; Delaporte, Céline; Esseiva, Pierre; Lock, Eric; Aalberg, Laura; Bozenko, Joseph S.; Dieckmann, Susanne; Dujourdy, Laurence; Zrcek, F.

doi:10.1016/j.forsciint.2007.10.001

Cited by 63 publications

(77 citation statements)

References 4 publications

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“…This analytical finding suggest that another routs of synthesis and a bigger range of raw material, excipients and active ingredients must be monitored, following the trends of drug dealers, once it is known that MDMA can be synthesized from different synthesis routes. In this context, chemical profile studies have been determined different contaminants or synthetic impurities, such as co-products, for example, may point to the use of one or the other pathway to obtain MDMA 11,12 . The 2C-B seems to be the most important substances within the substituted phenethylamines class of designer drugs and 25B-NBOMe appears as its novel and highly potent derivative 13 .…”

Section: Resultsmentioning

confidence: 99%

NBOMe Designer Drugs: GC-MS and LC-QTOF/MS Detection on Blotter Paper by Brazilian Federal Police (Rio Grande do Sul, Brazil)

Wayhs¹,

Reis²,

Mariotti³

et al. 2018

Braz. J. Foren. Sci.

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Abstract. The NBOMes are classified as new psychoactive substances and have recently become popular as drugs of abuse, being associated with several intoxication cases and even deaths, leading to its ban in several countries. Until now, the most widely used analytical instrument among forensic laboratories in Brazil is GC-MS. In this study, this instrumentation was employed for routine analyzes of twenty blotter paper seizure by Brazilian Federal Police (BFP) in the southernmost state of the country. However, to acquire more information about these samples, LC-QTOF/MS was used as a supplementary analysis to determinate degradation products, metabolites and unknown compounds. The GC-MS analysis detected only 25B-NBOMe, while the LC-QTOF/MS analysis detected 25B-NBOMe, 2C-B and MDMA. The compounds found in these analyzes are quite different from that found in the national profile of seizures by BFP, suggesting that another rout or supplier act in this region. For research and drug intelligence purposes the use of more versatile, sensitive and specific analytical tool provides a greater number of information that could be employed as a valuable strategy in the drug trafficking combat.

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Section: Resultsmentioning

confidence: 99%

NBOMe Designer Drugs: GC-MS and LC-QTOF/MS Detection on Blotter Paper by Brazilian Federal Police (Rio Grande do Sul, Brazil)

Wayhs¹,

Reis²,

Mariotti³

et al. 2018

Braz. J. Foren. Sci.

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“…Providing a model to apply this analytical strategy is extensive research that has examined statistical methods to determine cutting points for whether a drug originates from the same production batch Esseiva et al, 2003;Zingg, 2005;Anderson et al, 2007;Esseiva et al, 2007;Marquis et al, 2008;Weyermann et al, 2008;Esseiva, Gasté, Alvarez & Anglada, 2011). According to these studies, the pearson correlation has consistently been determined to be the most reliable method to see whether two or more drugs share enough characteristics to have originated from the same manufacturer.…”

Section: Network Analysis: Precursor Structuringmentioning

confidence: 99%

“…This study relies on 365 synthetic drugs that were obtained through a project commissioned by the federal government in response to concern over increased use of Providing a model to utilize drug composition data as an intelligence tool is extensive research that outlines statistical methods to determine whether drugs originate from the same production batch Esseiva et al, 2003;Zingg, 2005;Anderson et al, 2007;Esseiva et al, 2007;Weyermann et al, 2008;Marquis et al, 2008;Esseiva et al, 2011). These studies found that the pearson correlation serves as the most reliable statistical tool to determine cutting points at which drugs with shared characteristics belong to the same manufacturer.…”

Section: Sources Of Synthetic Drug Tabletsmentioning

confidence: 99%

Precursors and Prices

Ouellet

Morselli

2013

Journal of Drug Issues

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Research gathered on synthetic drug markets trails behind studies on other illegal drug markets. Synthetic drug's relatively recent classification as an illicit substance, coupled with its distinct characteristics that insulate it from detection has hindered the development of reliable assessments of the markets structural features. The purpose of this study is to provide reliable insight into the inner dynamics of Quebec's synthetic drug industry, focusing on its organizational features. Using information derived from 365 synthetic drugs seized by law enforcement over a one year period, this study will merge two techniques, drug composition and economic analyses, under a common framework to derive reliable and comprehensive assessments of the structure of Quebec's synthetic drug market. Drug composition analysis examines the drug's chemical and physical profile to make inferences about the market structure while the economic analysis examines price determinants for the same market, providing further insight into its dynamics and distinctive features. Findings from the drug composition analysis indicate that the synthetic drug market in Quebec is likely to be composed of a high number of small structures, indicating a competitive market. The economic analysis provided complementary information, finding that both differential production costs and trafficker-consumer relations may influence price variations, depending on the region. This study concludes by emphasizing that drug composition analysis should be diligently pursued by both researchers and enforcement organizations alike to effectively target and enhance our understanding of the intricate processes that underlie the synthetic drug market. iv

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“…En su revisión sobre el uso de meconio, uñas y lágrimas en el análisis de drogas, Katarzyn Madej [10] considera que una de las razones principales para el uso poco amplio de estas muestras es que los métodos analíticos requieren e instituciones [16][17][18] . El reto analítico lo constituye la gran diversidad de estructuras químicas posibles dentro del conjunto de impurezas.…”

Section: Análisis Gc-ms Unidimensionalunclassified

GC-MS: herramienta fundamental para el análisis de drogas de uso ilícito

Stashenko¹,

Martı́nez²

2012

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ResumoLa determinación cromatográfica de drogas de uso ilícito presenta retos importantes en varias etapas de la cadena analítica debido a la volatilidad relativamente baja de los analitos, a la diversidad grande de los posibles contaminantes y a las concentraciones bajas en las que se encuentran algunas sustancias de interés. La preparación de la muestra, el uso de agentes de derivación, los modos de operación del espectrómetro de masas para la detección y los diversos campos de aplicación del análisis GC-MS de sustancias controladas se discuten en este artículo junto con la presentación de algunos ejemplos recientes de estas aplicaciones. Palavras-chaveCromatografía de gases; cromatografía de gases acoplada a espectrometría de masas; sustancias controladas; drogas. GC-MS: fundamental tool for the analysis of drugs of illicit use AbstractThe chromatographic determination of illicit drugs poses important challenges at various stages along the analytical procedure, due to the low volatility of the analytes, the diversity of potential contaminants, and to the low concentrations of certain substances of interest. Sample preparation, the use of derivatization agents, different operating modes of the mass spectrometer for the detection, and the diverse application fields of the GC-MS analysis of illicit drugs are discussed in this article together with the presentation of some examples of these applications.

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Drug intelligence based on MDMA tablets data

Cited by 63 publications

References 4 publications

NBOMe Designer Drugs: GC-MS and LC-QTOF/MS Detection on Blotter Paper by Brazilian Federal Police (Rio Grande do Sul, Brazil)

NBOMe Designer Drugs: GC-MS and LC-QTOF/MS Detection on Blotter Paper by Brazilian Federal Police (Rio Grande do Sul, Brazil)

Precursors and Prices

GC-MS: herramienta fundamental para el análisis de drogas de uso ilícito

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