Drug-Induced Yawning—A Review

Patatanian, Edna; Williams, Nancy Toedter

doi:10.1345/aph.1q255

Cited by 13 publications

(15 citation statements)

References 32 publications

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“…Although functional connections between trigeminal neurons and nucleus tractus solitarius may explain the presence of nausea along with headache, nausea-which is also seen as a premonitory symptom-is thought to be a centrally developed symptom in migraine. The results of a study using H 15 2 O PET in the premonitory phase of a migraine attack triggered by nitroglycerin showed that nausea may develop independently of pain and trigeminal activation. 26 In addition, connections between paraventricular nucleus of hypothalamus and nucleus tractus solitarius and area postrema demonstrate the role of the hypothalamus in development of nausea and vomiting.…”

Section: Discussionmentioning

confidence: 99%

“…Second, our study did not assess the prophylactic medications for migraine. It is known that antidepressant drugs may induce yawning, 15 but both groups of patients with or without yawning had used these drugs similarly (21.4 vs 23.8%). Finally, we used multiple logistic regression analysis to determine the variables which may have an effect on yawning, but no adjustment for multiple comparisons was done in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Excessive yawning is seen in several neurological disorders such as vasovagal syncope, migraine, intracranial hypertension, epilepsy, pituitary tumors, and stroke. Iatrogenic yawning may develop due to the use of dopaminergic medication and serotonin reuptake inhibitors …”

mentioning

confidence: 99%

“…Iatrogenic yawning may develop due to the use of dopaminergic medication and serotonin reuptake inhibitors. 12,13,15 In this study, we aimed to determine the frequency of yawning accompanying migraine attacks and to investigate the relationship between yawning and the clinical features of migraine.…”

mentioning

confidence: 99%

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Migraine and Yawning

Güven

Çomoğlu

2017

Headache

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Our results demonstrated that yawning is a common self-reported symptom leading or accompanying migraine attacks and is associated with aura, nausea and/or vomiting, osmophobia, and cutaneous allodynia in patients with migraine. Although yawning is a rather frequently seen behavior, it is a unique and reliable symptom in patients with migraine that may offer an opportunity for early treatment of migraine attacks.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Migraine and Yawning

Güven

Çomoğlu

2017

Headache

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“…A prevailing hypotheses regarding premonitory symptoms has been that they involve the neurotransmitter dopamine . Part of the evidence supporting this hypothesis includes the observation that exogenously administered dopamine receptor agonists produce some of the same symptoms that are experienced by migraine patients in the premonitory phase, namely yawning, nausea, drowsiness, and lightheadedness . Conversely, dopamine receptor antagonists may reverse some of these symptoms and have been suggested to have the capacity to prevent the occurrence of subsequent headache.…”

Section: The Premonitory Phasementioning

confidence: 99%

The Evolution of a Migraine Attack – A Review of Recent Evidence

Charles

2012

Headache

143

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A migraine attack is an extraordinarily complex brain event that takes place over hours to days. This review focuses on recent human studies that shed light on the evolution of a migraine attack. It begins with a constellation of premonitory symptoms that are associated with activation of the hypothalamus and may involve the neurotransmitter dopamine. Even in the premonitory phase, patients experience sensitivity to sensory stimuli, indicating that central sensitization is a primary phenomenon. The migraine attack progresses to a phase that in some patients includes aura, which involves changes in cortical function, blood flow, and neurovascular coupling. The aura phase overlaps with the headache phase, which is associated with further changes in blood flow and function of the brainstem, thalamus, hypothalamus, and cortex. Serotonin receptors, nitric oxide, calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide, and prostanoids are demonstrated specific chemical mediators of migraine based on therapeutic and triggered migraine studies. A number of migraine symptoms persist beyond resolution of headache into a postdromal phase, accompanied by persistent blood flow changes in several brain regions. Although these phases of migraine have substantial temporal, neurochemical, and anatomical overlap, each represents an important window onto the pathophysiology of migraine as well as a target for therapeutic intervention. A comprehensive approach to migraine requires an understanding of the entire range of mechanisms and resultant symptoms that occur throughout the evolution of an attack. Key words: headache, positron emission tomography, magnetic resonance imaging, premonitory, aura, postdromeThe understanding of migraine pathophysiology continues to advance rapidly, bringing fresh opportunities for the development of novel acute and preventive therapies. It is convenient to describe the phases of a migraine attack (premonitory, aura, headache, postdrome) relative to the headache phase because headache is the most easily recognizable, stereotyped, and quantifiable feature of an attack. But for a significant number of patients, the other phases of a migraine attack can be more prolonged and even more disabling than headache. Growing evidence indicates that the phases of migraine do not occur in a discrete and linear fashion but rather reflect overlapping chemical, physiological, and anatomical mechanisms.

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Neurologic Symptoms as Adverse Drug Reactions

Jain

2021

Drug-Induced Neurological Disorders

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Drug-Induced Yawning—A Review

Abstract: Yawning is rarely a serious adverse reaction and is not frequently listed in the drug summary. Most available data are based on case reports, small studies, and older literature. Clinicians should be aware of the agents commonly triggering this behavior.

Cited by 13 publications

References 32 publications

Migraine and Yawning

Migraine and Yawning

The Evolution of a Migraine Attack – A Review of Recent Evidence

Neurologic Symptoms as Adverse Drug Reactions

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