Neurologic Symptoms as Adverse Drug Reactions

Jain, Kewal K.

doi:10.1007/978-3-030-73503-6_2

Cited by 1 publication

(2 citation statements)

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“…Pseudobulbar palsy is usually treated clinically using a combination of Western and Chinese medicine. Western medicine is often used to activate blood circulation and promote nerve recoveries, such as cerebral protein hydrolysate tablets and olanzapine, which can gradually restore damaged nerves [ 43 – 45 ]. However, some adverse effects are often associated with Western medicine.…”

Section: Discussionmentioning

confidence: 99%

“…Cerebral protein hydrolysate tablets may occasionally cause allergic reactions, including itching, rash, chills, low-grade fever, sometimes chest discomfort, headache, shortness of breath, and vomiting, and may trigger seizures and increase blood urea nitrogen [ 43 , 44 ]. Olanzapine has led to psychotic excitement and sleep disturbances in a few patients, but nausea and gastric discomfort were only seen in a few patients in clinical trials, in addition to occasional pruritus, nausea, psychotic excitement, and sleep disturbances, but the symptoms were mild [ 45 ]. Therefore, it is clinically relevant to promote the use of CENA in the treatment of pseudobulbar palsy.…”

Section: Discussionmentioning

confidence: 99%

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A Multicentre Randomized Controlled Clinical Study of Cross Electro-Nape-Acupuncture (CENA) for the Treatment of Pseudobulbar Palsy in Patients with Tracheotomy Intubation for Severe Cerebral Haemorrhage

Guo

Sun

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Objective. The objective is to evaluate the clinical efficacy of cross electro-nape-acupuncture (CENA) in the treatment of pseudobulbar palsy in patients with tracheotomy intubation for severe cerebral haemorrhage and to provide an innovative acupuncture method for the treatment of such patients. Methods. A total of 126 patients from six trial centres who met the inclusion criteria were randomly divided into three groups according to the random number table method in the ratio of 1 : 1 : 1, with 42 patients in each group, and the three groups were divided into CENA group, electro-acupuncture group, and acupuncture group. Each group’s acupuncture treatment lasted for 30 minutes, and the needles were removed at the end of the treatment. Acupuncture was performed once a week on Sunday only and twice a day from Monday to Saturday, a total of 4 weeks of treatment. The SWT, FDA, ChSWAL-QOL, and TCRGS scores of the three groups of patients before and after treatment were compared to evaluate the effect of CENA on remodelling the function of swallowing reflex and cough reflex and promoting the recovery of dysarthria and swallowing quality of life in pseudobulbar palsy in patients with tracheotomy intubation for severe cerebral haemorrhage. Results. After treatment, the WST and TCRGS grade scores decreased and the FDA and ChSWAL-QOL scores increased significantly in all three groups compared with the pretreatment scores and were statistically significant. There was a significant difference between the three groups for these four indicators after treatment; the comparison between groups showed significant differences in the CENA group compared to the electro-acupuncture and acupuncture groups. The efficiency of the CENA group was significantly better than that of the electro-acupuncture and acupuncture groups. Conclusion. Compared with the acupuncture and electro-acupuncture groups, the CENA could better promote the remodelling of swallowing function and cough reflex function, promote the recovery of dysarthria, and better improve the quality of life of patients with pseudobulbar palsy from tracheotomy intubation in severe cerebral haemorrhage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%