Drug‐induced urolithiasis

Hess, Bernhard

doi:10.1097/00042307-199807000-00013

Cited by 13 publications

(8 citation statements)

References 19 publications

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“…The remainder are comprised of cystine stones, infection stones and other rare forms of NL [1] , [2] . Drug-induced stone formation is negligible with an estimated frequency of 0.5–2% of all NL [9] , [10] , [11] .…”

Section: Introductionmentioning

confidence: 99%

Is Nephrolithiasis an Unrecognized Extra-Articular Manifestation in Ankylosing Spondylitis? A Prospective Population-Based Swedish National Cohort Study with Matched General Population Comparator Subjects

et al. 2014

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BackgroundAnkylosing spondylitis (AS) is associated with several extra-articular manifestations. Nephrolithiasis (NL) has not been recognized as one of those, however, several factors known to increase the risk of NL are at play in AS patients. The objective was to estimate rates and predictors of NL in Swedish patients with AS compared to the general population.Methods and FindingsWe performed a prospective population-based nationwide cohort study based on linkage of data from Swedish registries. 8,572 AS patients were followed for 49,258 person-years (py) and 39,639 matched general population comparators were followed for 223,985 py. Patients were followed prospectively together with comparator subjects from January 2001 through December 2009. The first occurrence of NL during follow-up was the primary outcome. Hazard Ratios (HR) were used to compare these rates adjusting for comorbidities and treatment, and to assess predictors for NL. Mean age at study entry was 46 years (inter quartile range 36–56 years), 65% were males. Based on 250 vs. 466 NL events, the adjusted HR of NL in AS patients was 2.1 (95%CI 1.8 to 2.4). Predictors of NL within the AS group included prior diagnosis of inflammatory bowel disease (IBD) (HR 2.3; 95%CI 1.7 to 3.3), prior diagnosis of NL (HR 16.4; 95%CI 11.5 to 23.4), and patients receiving anti-TNF treatment (HR 1.6; 95%CI 1.2 to 2.1). Male sex was a risk factor for NL both in AS patients and in the general population.LimitationsThe risk for residual confounding and inability to study the chemical nature of NL were considered the main limitations of the study.ConclusionsPatients with AS are at increased risk of NL, which may be considered a novel extra-articular manifestation. Previous history of NL, IBD, AS disease severity and male sex were identified as predictors of NL in AS.

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Section: Introductionmentioning

confidence: 99%

Is Nephrolithiasis an Unrecognized Extra-Articular Manifestation in Ankylosing Spondylitis? A Prospective Population-Based Swedish National Cohort Study with Matched General Population Comparator Subjects

et al. 2014

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“…Renal stone formation by the precipitation of a drug or one of its metabolites has been described for certain medicines. It has been estimated that 0.44% of all renal stones are formed in this manner [ 4 ]. A small number of patients with ulcerative colitis presenting with sulfasalazine-induced urolithiasis has been reported.…”

Section: Discussionmentioning

confidence: 99%

“…The calculi were composed of sulfapyridine in all cases, a metabolite specific to this drug [ 5 ]. Other sulfa-containing drugs have also been reported to precipitate in the urinary tract, as well as magnesium trisilicate, ciprofloxacin, triamterene, indinavir, and ephedrine alone or in combination with guaifenesin [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

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Mesalazine-induced renal calculi

2013

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Patient: Female, 32Final Diagnosis: Renal colicSymptoms: Acute colic pain • macrohematuriaMedication: MesalazineClinical Procedure: CT scan of urinary tract • cystoscopy • gynecological consultation • stone analysisSpecialty: Gastroenterology and Hepatology • Clinical PharmacologyObjective:Unexpected drug reactionBackground:Mesalazine, a 5-aminosalicylic acid compound, is one of the cornerstones in modern treatment regimens of ulcerative colitis. It is generally well tolerated, although adverse reactions such as nephrotoxicity, perimyocarditis, and pancreatitis have been reported.Case Report:We report the case of a 32-year-old woman with colitis who developed recurrent episodes of renal colic after introduction of mesalazine to her treatment. Biochemical analysis of the stones showed that they were composed of crystalized drug material.Conclusions:To our knowledge this is the first report of mesalazine precipitation in the urinary tract. We believe that it is vital for physicians to recognize this potentially severe adverse effect in the use of this treatment.

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“…La primera, ciertos medicamentos aumentan las tasas de excreción de los componentes naturales que llevan a la formación de cálculos. En segundo lugar, la formación de cálculos realmente inducida por fármacos se produce directamente por la precipitación de un fármaco o de su metabolito en el tracto urinario 59 . Por ejemplo, los fármacos inhibidores de proteasa usados en tratamiento para el VIH, entre ellos atazanavir 20 e indinavir para el cual, su uso prolongado ha sido asociado con una incidencia del 4% de urolitiasis.…”

Section: Estilos De Vidaunclassified

Fisiopatología asociada a la formación de cálculos en la vía urinaria

García‐Perdomo¹,

Solarte

España

2016

Urología Colombiana

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Urolitiasis;Factores sociodemográficos; Factores de riesgo Resumen La urolitiasis se ha convertido en una enfermedad crónica que ha tenido un gran impacto en la calidad de vida y en la situación laboral de quien la padece; su tasa de prevalencia y recurrencia es cada vez mayor, lo que genera un gran impacto socioeconómico en cualquier país al afectar el sistema de salud. Se han identificado numerosos factores inherentes a la biología humana y algunas variables sociodemográficas, que favorecen el desarrollo de cálculos renales; por lo cual, en esta revisión se describen los principales factores que influyen en la formación de urolitiasis, permitiendo intervenir oportunamente sobre algunos de ellos.

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Drug‐induced urolithiasis

Cited by 13 publications

References 19 publications

Is Nephrolithiasis an Unrecognized Extra-Articular Manifestation in Ankylosing Spondylitis? A Prospective Population-Based Swedish National Cohort Study with Matched General Population Comparator Subjects

Is Nephrolithiasis an Unrecognized Extra-Articular Manifestation in Ankylosing Spondylitis? A Prospective Population-Based Swedish National Cohort Study with Matched General Population Comparator Subjects

Mesalazine-induced renal calculi

Fisiopatología asociada a la formación de cálculos en la vía urinaria

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