Drug‐Induced Stones

Daudon, Michel; Jungers, Paul

doi:10.1002/9781118405390.ch10

Cited by 5 publications

(4 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ante estos casos de cristalurias poco frecuentes y sobretodo en las medicamentosas en las que la morfología puede ser confusa ya que es similar en varios compuestos, es fundamental realizar análisis accesorios como la microscopía polarizada y el FTIR para llegar a la naturaleza química del cristal (4,7,8). Resaltamos la importancia del trabajo colaborativo y coordinado de varias instituciones del estado en este reporte de casos, que pone de manifiesto las capacidades instaladas a nivel nacional.…”

Section: Discussionunclassified

“…La acción de los mismos puede ser por mecanismos indirectos, favoreciendo alteraciones metabólicas caracterizadas por un aumento de la concentración de promotores de cristalización como la hipercalciuria, la hiperuricosuria e hiperoxaluria, o bien por mecanismos directos donde es el mismo fármaco o sus metabolitos los que empleados en dosis altas y eliminados en la orina con solubilidades bajas precipitan formando cristales. En este último caso se habla de cristalurias y litiasis medicamentosas propiamente dichas (3,4).…”

Section: Introductionunclassified

See 1 more Smart Citation

Drug induced crystalluria in the Emergency Laboratory: Report of two cases

Guillén

Franco

Sánchez

et al. 2016

Mem. Inst. Investig. Cienc. Salud

View full text Add to dashboard Cite

Ciertos fármacos que son excretados en orina, como los antibióticos, pueden formar cristales cuando la dosis empleadas son elevadas, la diuresis se encuentra disminuida o el pH de la orina es ácido. Los eventos de cristaluria medicamentosa son poco frecuentes y pueden ser cuadros asintomáticos e incluso originar fallos renales agudos. En este reporte se describen dos casos: una mujer de 26 años con cristaluria de ampicilina y una niña de 8 años con cristaluria de amoxicilina, registrados en el laboratorio de urgencias del Hospital Central del Instituto de Previsión Social. El análisis del sedimento fue realizado empleando microscopía óptica, luego los cristales fueron sometidos a microscopía de polarización y espectrofotometría infrarroja logrando la identificación exacta de la naturaleza química de los cristales. Este es el primer reporte de cristaluria medicamentosa del país y pone de manifiesto la importancia del trabajo colaborativo entre instituciones del estado. Palabras clave: Cristaluria medicamentosa, FTIR, microscopía de polarización Drug induced crystalluria in the Emergency Laboratory: Report of two cases A B S T R A C TCertain drugs that are excreted in the urine, including antibiotics, could induce the formation of crystals when the dose used is high, the diuresis is low or the pH of the urine is acid. The events of drug induced crystalluria are rare and could be asymptomatic or could cause acute renal failure. In this report, we describe two cases: One of a 26-year-old woman with ampiciline crystalluria and a 8-year-old child with amoxiciline crystalluria, both registered at the Emergency Laboratory of the Central Hospital of the Instituto de Prevision Social. The analysis of the urinary sediment was made by conventional microscopy, and then the crystals were studied by polarized light microscopy and infrared spectroscopy achieving the exact identification of the chemical nature of the crystals. This is the first report of drug induced crystalluria in the country and shows the importance of the colaborative work between state institutions.

show abstract

Section: Discussionunclassified

Section: Introductionunclassified

Drug induced crystalluria in the Emergency Laboratory: Report of two cases

Guillén

Franco

Sánchez

et al. 2016

Mem. Inst. Investig. Cienc. Salud

View full text Add to dashboard Cite

show abstract

“…[30][31][32][33][34] Two main mechanisms are involved in the formation of drug-induced renal calculi: (i) the drug and/or its metabolites are total or partial components of the calculi; and (ii) the drug induces the formation of calculi through its metabolic action by interfering with Ca oxalate or purine metabolism. [35][36][37] In both cases, a lithogenic substance may deposit on renal calculi already present. Therefore, patients with a history or presence of renal calculi seem to be more exposed to the risk of drug-induced renal calculi, and in our previous study we reported that urolithiasis risk is higher in patients who have urolithiasis.…”

Section: Drug-induced Urolithiasismentioning

confidence: 99%

“…This suggests that the formation of drug-induced calculi involves an interplay of risk factors specific for the implicated drug, some of which depend on the drug itself and others that relate to the patient. [36][37][38] The true prevalence of drug-induced renal calculi is likely to be underestimated in most studies. However, in some cases, changes in urine biochemistry induced by the drug may provoke crystallisation of metabolic compounds with an unusual morphology, which may draw attention to the possibility that there are peculiar conditions for the renal calculi formation.…”

Section: Drug-induced Urolithiasismentioning

confidence: 99%

Kidney Stones and Ceftriaxone

Dursun¹,

Ötünçtemur

Özbek

2015

EMJ Urol

View full text Add to dashboard Cite

Metabolic causes such as hypercalciuria, urinary tract infection, and obstruction are the most common aetiologies of urolithiasis, and drugs, although important in this regard, are rarely the cause of urolithiasis. Administration of one of these drugs, ceftriaxone (CTX), has been associated with biliary pseudolithiasis in adult and paediatric patients, and rarely may cause urolithiasis. Several factors, including drug concentration and incubation time, are very important for determining the degree of CTX/calcium (Ca) crystallisation in the urine. According to this data, CTX crystallisation was a dose and time-dependent reaction. It is particularly important to monitor patients on high-dose long-term CTX treatment with the urinary Ca to creatinine ratios, ultrasound sonography, and renal function testing, as these individuals may be at greater risk of large stones and renal damage. This type of screening may help prevent permanent complications in the future. This underlying review will help to educate readers on the pathophysiology and interaction between CTX and urolithiasis.

show abstract

Urinary Stone Disease and Nephrocalcinosis

Eðvarðsson

Sas

2022

Pediatric Nephrology

View full text Add to dashboard Cite

Drug‐Induced Stones

Cited by 5 publications

References 52 publications

Drug induced crystalluria in the Emergency Laboratory: Report of two cases

Drug induced crystalluria in the Emergency Laboratory: Report of two cases

Kidney Stones and Ceftriaxone

Urinary Stone Disease and Nephrocalcinosis

Contact Info

Product

Resources

About