Drug-induced oral lichenoid reactions. A literature review

Abstract

The terms oral lichenoid reactions or oral lichenoid lesions refer to lesions histologically and clinically similar to oral lichen planus, though with the particularity that in these cases the underlying cause is identifiable. In addition, these lesions are described according to the causal factor involved, including alterations resulting from direct contact with dental restoration materials, drug-related lesions, and lesions associated to graft-versus-host disease. Drug-induced oral lichenoid reactions or oral lichenoid lesions were first cited in 1971 by Almeyda and Levantine. Since then, many drug substances have been associated with such lesions. The most common agents are nonsteroidal antiinflammatory drugs and angiotensin converting enzyme inhibitors. Key words: Oral lichenoid reactions, oral lichenoid lesions, drugs, medicines, drug-induced oral lesions.Serrano-Sánchez P, Bagán JV, Jiménez-Soriano, Sarrión G. Druginduced oral lichenoid reactions. A literature review. J Clin Exp Dent. 2010;2(2):e71-5.

Oral and vulvo-vaginal lichenoid reactions due to mitotane (Lysodren)

“…[12] Since, many substances were associated with these lesions. Serrano-Sànchez et al (2010) [13] proposed a review of the literature of different drugs that may cause these lichenoid reactions. We completed this review and proposed a table with different drugs incriminated in oral lichenoid lesions (Table 1).…”

Oral lichenoid lesions and serum antinuclear antibodies in Thai patients

“…OLDR may develop in the oral cavity after administration of certain drugs, for example, oral hypoglycemic agents, angiotensin‐converting enzyme inhibitors, and non‐steroidal anti‐inflammatory drugs (NSAIDs), penicillamine, or gold salts, etc. . The most reliable diagnosis of OLDR is when the lesions resolve after withdrawal of the suspected drugs, and the reaction recurs when the patient is rechallenged with the same drug.…”

Diabetes mellitus and hepatitis c in generalised lichen planus: a case control study

“…14 Also, the risk of diabetic drugs inducing lichenoid lesions could be ruled out by confirming through skin biopsy. 15 There is a need for future studies to establish the response rate to treatment in GLP among diabetic patients with good and bad glycaemic controls. 16 Unlike literature, in our study there was also no significant association of HCV with GLP in both the sexes.…”