Drug-induced Malabsorption

Kendall, M. J.; Chan, Keith

doi:10.3109/00498257309151597

Cited by 8 publications

(1 citation statement)

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“…This observation would seem to suggest that the extent of propranolol metabolism during absorption of the drug is reduced in coeliac patients due to morphological and/or enzyme changes in gut mucosa. A malabsorption syndrome which is functionally and histologically similar to that found in coeliac disease can be produced in normal subjects by administering neomycin over a short period of time (11). We have therefore attempted to evaluate the influence of changes in structure and function of gut mucosa by comparing the rate of absorption and bioavailability of oxprenolol before and after 5 days treatment with neomycin.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing the absorption of oxprenolol A pharmacokinetic study

Kendall

Mitchard

West

et al. 1976

European Journal of Drug Metabolism and Pharmacokinetics

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The absorption and elimination of oxprenolol after intravenous and oral administration has been studied in six healthy male volunteers.The plasma concentration/time curve after intravenous administration is described by an equation consisting of three exponential terms. The terminal half-life of 4.5 hours is longer than previously reported and is consistent with the observed effect on heart rate after a single dose.The bioavailability of oxprenolol has been estimated from a comparison of the area under the curve values after oral and intravenous administration, and shown to be 25 % and 30 % for 80 mg oxprenolol in tablet and solution form respectively. Treatment of the volunteers with either metoclopramide which decreases gastric retention and increases intestinal motility, or neomycin which produces a deterioration in the integrity of the intestinal mucosa, did not appear to alter the absorption of oxprenolol.

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Section: Introductionmentioning

confidence: 99%