Drug-induced lupus erythematosus

Abstract

Drug-induced lupus is a syndrome which share symptoms and laboratory characteristics with the idiopathic systemic lupus erythematosus (SLE). The list of medications implicated as etiologic agents in drug-induced lupus continues to grow. The terms used for this condition are lupus-like syndrome, drug-induced lupus erythematosus (DILE) and drug related lupus. More than 80 drugs have been associated with DILE. The first case of DILE was reported in 1945 and associated with sulfadiazin. In 1953 it was reported that DILE was related to the use of hydralazine. Drugs responsible for the development of DILE can divided into three groups, but the list of these drugs is quite long because new drugs are included yearly in the list. The syndrome is characterised by arthralgia, myalgia, pleurisy, rash and fever in association with antinuclear antibodies in the serum. Recognition of DILE is important because it usually reverts within a few weeks after stopping the drug

Clinical Course of Drug-Induced Lupus and Immunological Profile of Patients

“…Most authors consider APl conditionally non-pathogenic. However, there are reports of thrombotic manifestations in patients with Dil (1,5,7). in our study we carried out tests for one type of APl anticardiolipin antibodies and 40 % of the patients showed positive tests results.…”

“…only cases with a clear anamnestic linkage are considered as DIL (1,8). Literature-based data analysis reveals that the incidence of Dil is between 6 % and 12 % of patients with lupus.…”

“…According to some authors (12), the clinical course of Dil varies from conditions with individual affected organs to severe systemic inflammatory conditions, dominated by manifestations of vasculitis. Systemic DIL usually is characterized by typical lupus-like symptoms, including skin signs, mild systemic involvement, and a typical laboratory profile (1,6). …”

Drug-induced lupus

“…Факторами риска ЛВ считают ацетиляторный статус пациента (медленные «ацетиляторы») и генетическую пред- [18,19].…”

Systemic lupus erythematosus induced by cefepime

“…2 Myalgias are present in approximately half of patients. Less common signs are fever, pleurisy, hepatitis, and pericarditis.…”