Systemic lupus erythematosus induced by cefepime

Mendese, Gary; Demierre, Marie France

doi:10.1016/j.jaad.2010.06.055

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Interestingly, cutaneous manifestations appear to be common in drug-induced lupus, with phenytoin-induced uncommon rashes like livedo racemosa also being reported [6]. Cefepime, a fourth-generation cephalosporine was also reported to cause drug-induced lupus [7], and so even the newer antibiotics may have this ability. Ticlopidine, an antiplatelet drug was also implicated in a case report of two men aged 76 and 81 [8].…”

Section: Drug-induced Rheumatic Diseasesmentioning

confidence: 99%

Drug-induced rheumatic diseases

Bukhari

2012

Current Opinion in Rheumatology

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Section: Drug-induced Rheumatic Diseasesmentioning

confidence: 99%

Drug-induced rheumatic diseases

Bukhari

2012

Current Opinion in Rheumatology

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Penicillins, cephalosporins, other beta-lactam antibiotics, and tetracyclines

Toussaint¹,

Gallagher²

2014

A Worldwide Yearly Survey of New Data in Adverse Drug Reactions and Interactions

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Drug-induced lupus erythematosus in childhood: Case-based review

Kaya Akca,

Sener,

Batu

et al. 2024

Lupus

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Background Drug-induced lupus erythematosus (DILE) is the development of lupus-like syndrome following a drug exposure. DILE has been reported less frequently among children than adults. Methods In this study, we present four children with DILE and similar published cases through a systematic literature review. Results We report four children (three girls and one boy) who developed DILE associated with the use of topiramate, doxycycline, etanercept, and ethosuximide. Three of them were positive for anti-histone antibodies. In all patients, the drug was discontinued and symptoms resolved completely. The literature review revealed 48 articles describing 61 children with DILE. In the evaluation of 65 patients (our 4 patients and 61 patients from the literature), the most frequently reported drugs associated with DILE were ethosuximide ( n = 13) and minocycline ( n = 12). Fever ( n = 33), arthralgia ( n = 31), rash ( n = 30), and arthritis ( n = 29) were the most common clinical manifestations. Antinuclear antibody (ANA) was positive in 93.5% of patients and anti-histone antibodies were detected in 72.2% of the patients. As for treatment, the responsible drug was discontinued in all patients, and corticosteroids were initiated in 53.3%. Improvement was achieved in 92.0% of patients. Conclusion For children presenting with SLE features, proper drug history is crucial since DILE may be more frequent than anticipated. An association of the relevant drug with the symptoms, and resolution of symptoms on drug withdrawal provides evidence for the diagnosis of DILE.

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Systemic lupus erythematosus induced by cefepime

Cited by 3 publications

References 7 publications

Drug-induced rheumatic diseases

Drug-induced rheumatic diseases

Penicillins, cephalosporins, other beta-lactam antibiotics, and tetracyclines

Drug-induced lupus erythematosus in childhood: Case-based review

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