Drug-induced liver injury in children

Amin, Mansi; Harpavat, Sanjiv; Leung, Daniel H.

doi:10.1097/mop.0000000000000264

Cited by 34 publications

(23 citation statements)

References 47 publications

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“…La intoxicación por estos productos puede ocasionar un 10-20 % de hepatitis aguda grave y requerir trasplante de hígado. 3,4 Las hojas del TV y del té negro provienen de Camellia sinensis; la diferencia entre ambos es que el segundo se oxida y el primero puede ser fermentado. 5 El TV contiene varios flavonoides polifenólicos y catequinas; el más abundante de ellos es la epigalocatequina galato (epiogallocatechin gallate; EGCG, por sus siglas en inglés).…”

Section: Discussionunclassified

Hepatitis grave producida por intoxicación con té verde en un niño. Presentación de un caso

2019

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Presentación de casos clínicos RESUMENEl daño hepático inducido por hierbas es una reacción adversa relacionada con el uso de medicina herbaria, incluida en el grupo de daño hepático inducido por drogas. El uso terapéutico de hierbas medicinales es cada vez más frecuente por la creencia de que los productos naturales o hierbas son siempre seguros. En Estados Unidos, la incidencia de toxicidad alcanza un 9 % y, en países de Asia, un 19-63 % de los casos totales de daño hepático inducido por drogas. El té verde es obtenido de las hojas de la Camellia sinensis. Las hojas recién cosechadas son estabilizadas por calentamiento en seco para inactivar la enzima polifenol y luego se secan rápidamente. Su consumo ha aumentado en los últimos años, y se han documentado reacciones hepatotóxicas. Se presenta un caso de hepatitis aguda grave asociada al consumo de té verde en un niño de 2 años. Palabras clave: té verde, Camellia sinensis, enfermedad hepática inducida por sustancias y drogas, hepatitis tóxica, niños. ABSTRACTHerb-induced liver injury is a type of adverse drug reaction related to using herbal medicine, and now is a segment of druginduced liver injury. The use of herbal products has increased significantly, because it is generally regarded as safe and natural by the public. In the United States, the incidence reaches 9 % and, in the countries of Asia, 19-63 % of the total cases of druginduced liver injury. Green tea is obtained from the leaves of the Camellia sinensis. Freshly harvested leaves are stabilized by dry heating to inactivate the polyphenol enzyme and then dried quickly. Its consumption has increased in recent years and has been reported with hepatotoxic reactions. We present a case of severe hepatitis related to the consumption of green tea in a 2-year-old child.

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Section: Discussionunclassified

Hepatitis grave producida por intoxicación con té verde en un niño. Presentación de un caso

2019

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“…Valproate hepatitis develops in several weeks or months after start of treatment having a frequency as 1:10 000 but in combination with other anticonvulsants (especially with phenobarbital and phenytoin) -in 1,5 times frequently. In addition it's necessary to emphasize that children of early age are more prone than adults to disturbances of mitochondrial functioning at the time of drug use caused including the restricted capacities for synthesis of carnitine and also its loss in case of renal diseases [16].…”

Section: Risk Of Development Of Drug-induced Hepatitismentioning

confidence: 99%

Drug-Induced Liver Diseases in Children and Adolescents

Postnikov¹

2019

AJP

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Many drugs (now it's known more than 1200) are associated with hepatic side effects. Children (especially newborns and infants) are unique population with specific characteristics of absorption, metabolism and elimination of drugs that can predispose to hepatotoxicity. Aim of this review is to estimate risk factors of hepatotoxicity related to the patients' peculiarities and drug itself, also to describe some mechanisms and types of drug-induced liver disease (DILD) and beside this to offer some methods of the treatment and prevention of hepatotoxicity. In children the most often mentioned drugs caused DILD are antibiotics, psychotropics and NSAIDs and the main type of DILD is acute hepatitis with mortality of 10%. To conclude it's highly important to monitor activity of hepatic enzymes (ALT, AST, AP) during treatment by potentially hepatotoxic drugs in patients from risk groups (early age, any liver disease, diabetes mellitus, obesity, poor nutritional status) in order to timely withdraw offending drug and prescribe hepatoprotectors or even perform liver transplantation.

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“…3,4 La amplia gama de presentación clínica, la multiplicidad de agentes causantes y la falta de pruebas diagnósticas específicas hacen que su diagnóstico sea dificultoso. A pesar de su baja incidencia en la población general, se debe considerar siempre la posibilidad de DILI en pacientes con enfermedad hepática aguda idiopática.…”

Section: A H E P a T O T O X I C I D A D P O R Drogas Y Sustanciasunclassified

El hígado y la toxicidad por drogas, hierbas y suplementos dietéticos

2017

Arch Argent Pediat

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Drug-induced liver injury in children

Cited by 34 publications

References 47 publications

Hepatitis grave producida por intoxicación con té verde en un niño. Presentación de un caso

Hepatitis grave producida por intoxicación con té verde en un niño. Presentación de un caso

Drug-Induced Liver Diseases in Children and Adolescents

El hígado y la toxicidad por drogas, hierbas y suplementos dietéticos

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