Drug-Induced Hypoglycemia: A Systematic Review

Murad, M. Hassan; Coto-Yglesias, Fernando; Wang, Amy T.; Sheidaee, Nasim; Mullan, Rebecca J.; Elamin, Mohamed B.; Erwin, Patricia J.; Montori, Víctor M.

doi:10.1210/jc.2008-1416

Cited by 191 publications

(115 citation statements)

References 22 publications

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“…Hypoglycemia may occur in patients without DM (non-DM) because of endocrine, renal, and liver disorders, or after use of alcohol and certain medications. 1,2 Hypoglycemia after bariatric surgery has also been reported. 3 Often, severe hypoglycemic episodes are treated at home or at the work place by family members, coworkers, and friends without requiring emergency medical services (EMS).…”

Section: Population-based Study Of Severe Hypoglycemia Requiring Emermentioning

confidence: 98%

Population-Based Study of Severe Hypoglycemia Requiring Emergency Medical Service Assistance Reveals Unique Findings

Parsaik

Carter

Pattan

et al. 2012

J Diabetes Sci Technol

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Abbreviations: (AI) adrenal insufficiency, (CGM) continuous glucose monitoring, (CI) confidence interval, (CLD) chronic liver disease, (CSII) continuous subcutaneous insulin delivery, (DM) diabetes mellitus, (EMS) emergency medical services, (ER) emergency room, (ERT) emergency room transportation, (ESRD) end-stage renal disease, (HR) hazard ratio, (IQR) interquartile range, (MDI) multiple daily insulin injection, (non-DM) with no diabetes mellitus, (OAA) oral antihyperglycemic agents, (SD) standard deviation, (SFUI) sulphonylureas alone or in combination with insulin, (TIDM) type 1 diabetes mellitus, (T2DM) type 1 diabetes mellitus

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Section: Population-based Study Of Severe Hypoglycemia Requiring Emermentioning

confidence: 98%

Population-Based Study of Severe Hypoglycemia Requiring Emergency Medical Service Assistance Reveals Unique Findings

Parsaik

Carter

Pattan

et al. 2012

J Diabetes Sci Technol

View full text Add to dashboard Cite

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“…Mild, and even potentially asymptomatic hypoglycaemia has not routinely been documented in the literature, reinforcing the under-reporting of drug-induced hypoglycaemia. In the most recent systematic review conducted that focused on patients taking medications at recommended doses, severe, symptomatic hypoglycaemic episodes were still experienced [Murad et al 2009]. Cases of hypoglycaemia without apparent cause should alert healthcare professionals to the possibility of unintentional oral hypoglycaemic agents' ingestion.…”

Section: Discussionmentioning

confidence: 99%

Glibenclamide-induced profound hypoglycaemic crisis: a case report

Hussain

Ali

Khan

et al. 2016

Therapeutic Advances in Endocrinology

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The value of sulphonylureas in the long-term treatment of type II diabetes has been questioned. The potential benefits of an antidiabetic drug must be carefully weighed against the risk of developing hazardous adverse effects like hypoglycaemia. We present drug-induced hypoglycaemia in a 77-year-old Pakistani male who had hypertension, type II diabetes and renal parenchymal disease (grade I), presented to the emergency department complaining of a 1-day history of fever, loose motions and drowsiness. His fever was low grade, intermittent, and not associated with rigors and chills. He had four episodes of watery stools for 1 day, with no associated vomiting but with drowsiness. He was aphasic, unable to walk and did not recognize his family members. The patient was taken to his local doctor who found him to be hypoglycaemic, with a blood sugar of 45 mg/dl. He was managed with intravenous (IV) dextrose and referred to the hospital. Hypoglycaemia is perhaps the most widespread and underreported complication of oral hypoglycaemic agents and may lead to overwhelming morbidity and mortality. Patient evaluation and proper counselling may help in identifying patients at greatest risk and avoid complications associated with these commonly prescribed drugs.

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“…Several medications have been reported to increase the risk of hypoglycemia. Most commonly reported offending agents included trimethoprim-sulfamethoxazole, βB, quinolones, pentamidine, quinine, angiotensin-converting enzyme inhibitors (ACEI), angiotension receptor blockers (ARB) and insulin-like growth factor [101,102]. However, A systematic review showed that stronger evidence supported the associations between quinolones, quinine, pentamidine and hypoglycemia as discussed below [101].…”

Section: Hypoglycemiamentioning

confidence: 99%

“…-Basal-bolus regimen using long acting insulin [97,101] -In patients already on BBI regimen; use 140-150% of BBI [7] -Start NPH 3 units/mg of dexamethasone or equivalent in divided doses twice daily [7] Betamethasone 0.6 30 ? 36-72 Table 1.…”

Section: Glucocorticoidsmentioning

confidence: 99%