Glibenclamide-induced profound hypoglycaemic crisis: a case report

Hussain, Arshad; Ali, Iftikhar; Khan, Aziz; Khan, Tahir Mehmood

doi:10.1177/2042018816632440

Cited by 5 publications

(4 citation statements)

References 7 publications

(7 reference statements)

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“…The concept that sulfonylureas cause hypoglycemia as a class effect is well reported in literature [27][28][29]. However this review article adds the additional point that the hypoglycemia caused can be very severe and in the very severe state, it can be symptomatic or asymptomatic hypoglycemia as depicted by glimepiride induced hypoglycemia, glibenclamide induced hypoglycemia and gliclazide induced hypoglycemia cited in this review.…”

Section: Casementioning

confidence: 82%

Sulfonylureas Induced Hypoglycemia in Diabetics - A Review

Ademolu¹

2019

IJDE

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Diabetes is a metabolic disorder of glucose characterized by glucotoxicity, lipotoxicity and insulin resistance. In insulin resistance states, a higher level of insulin is needed to generate the usual body response to keep plasma glucose at physiologic level. The type 2 diabetics with insulin resistance cannot keep plasma glucose normal not because of absolute insulin deficiency but due to a relative deficiency as insulin is now required at a higher plasma level to achieve a near physiological or physiological plasma glucose level. Hence the need for a chemical agent to increase insulin secretion from the pancreatic beta cells at pharmacological dose (insulin secretagogues) was conceptualized and arrived at. Sulfonylureas are insulin secretagogues. Two generations of sulfonylurea's are in use. The first and second. The class effects of sulfonylurea include weight gain, allergic reaction and hypoglycemia. But not enough emphasis is placed on the severity and grading of the hypoglycemia complicating use of sulfonylureas. Meanwhile hypoglycemia induced by sulfonylurea use is of various degree, severity and duration. The classification of hypoglycemia into grades in ADEMOLUS CLASSIFICATION OF HYPOGLYCEMIA makes it easier for scientist to understand, compare and monitor the severity of sulfonylureas. Mrs KFO is a 67 years old diabetic diagnosed over 8 years ago. She had asymptomatic hypoglycemia with a glucometer reading low (ADEMOLUS PHENOMENON) on a clinic day visit. She had been on glimepiride for three years. Mrs A. F. is a 75 years old diabetic diagnosed 4 years prior to presentation. She had a glucometer reading of low during a random blood sugar check at 8pm on day 2 of admission with associated general body weakness. She was on metformin and glibenclamide. Mrs. I E is a 72 years old diabetic who had a glucometer reading of low during her outpatient clinic visit. She was on gliclazide. Sulfonylureas use has been shown by these cases to be associated with symptomatic and asymptomatic very severe hypoglycemia. A possibility of synthesizing a new equally potent third generation of sulfonylureas with minimal or no hypoglycemic effect should be looked into.

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Section: Casementioning

confidence: 82%

Sulfonylureas Induced Hypoglycemia in Diabetics - A Review

Ademolu¹

2019

IJDE

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“…For patients in a hypoglycemic coma, timely analysis to identify the cause and treatment for correcting hypoglycemia is crucial. Glibenclamide-induced hypoglycemia has mostly been reported in adults with diabetes (Leblanc et al, 2004 ; Hussain et al, 2016 ; Douros et al, 2018 ). The treatment of severe hypoglycemia is divided into three major aspects.…”

Section: Discussionmentioning

confidence: 99%

Case report: Fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children

Song

Jia

Shi

2023

Front. Behav. Neurosci.

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In recent years, the prevalence of diabetes in China has significantly increased, and glibenclamide is widely used as a basic hypoglycemic drug in China's primary clinical practice. There are many left-behind children in the grass-roots areas in China and various dangerous incidents of children taking drugs by mistake continue to occur. This article reports a case of cerebral edema and fatal cerebral hernia caused by hypoglycemia induced by mistakenly ingesting glibenclamide in a child. This is the first reported case in China of a child who died from brain herniation caused by accidental administration of glibenclamide. This case reminded that clinicians must comprehensively consider the cause of convulsions and coma in children with unknown causes, ask the history in detail and cannot ignore the risk of hypoglycemic convulsions and coma. When hypoglycemic is detected, high concentration of glucose should be given promptly to normalize blood glucose. When dealing with unexplained convulsions and comatose children, clinical pediatricians must be alert to the possibility of accidental medication.

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“…The absorbance was measured using a UV-600 ultraviolet-visible spectrophotometer(Beijing LabTech). 1 H NMR and 13 C NMR spectra were obtained using a 500 MHz Bruker spectrometer in DMSOd6 with TMS as an internal standard. All the reaction was monitored through HPLC in an Agilent 1200 series system.…”

Section: Experimental Chemistrymentioning

confidence: 99%

“…Such compounds are widely used in medicine and pesticides and have high research value. In medicine, it has anti-diabetic, 1 antibacterial, 2 anti-cancer, 3 anti-inflammatory, 4 diuretic 5 and other effects. In terms of pesticides, sulfonylurea compounds are the most widely used herbicides in the world.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Activity Evaluation of Imidazole Heterocyclic Sulfonylurea Compounds

Xuan¹,

Li²,

Pei³

et al. 2021

HETEROCYCLES

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Sulfonylurea herbicides are the most widely used herbicides in the world. They have the advantages of high efficiency, good selectivity, and no toxicity to human and animals. In this study, sulfonylureas containing imidazole heterocycles were synthesized on the basis of computer simulation of molecular docking, and the biological activity was evaluated. It shows that the compound has a good inhibitory effect on the ALS and a certain inhibitory effect on the phytopathogenic fungi of Curvularia lunata and Curvularia mebaldsii. Its inhibitory rate at concentration of 50 mg/L is similar to that of the carbendazim.This research provides the basis for further optimization of the structure of imidazolium heterocyclic sulfonylurea and the synthesis of its derivatives.

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Glibenclamide-induced profound hypoglycaemic crisis: a case report

Cited by 5 publications

References 7 publications

Sulfonylureas Induced Hypoglycemia in Diabetics - A Review

Sulfonylureas Induced Hypoglycemia in Diabetics - A Review

Case report: Fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children

Synthesis and Biological Activity Evaluation of Imidazole Heterocyclic Sulfonylurea Compounds

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