Drug-Induced Hyperprolactinemia in the Clinical Practice of an Internist

Abstract

Hyperprolactinemia (HPRL) is one of the most common neuroendocrine syndromes which can be either a manifestation of an independent disease (pituitary tumors) or a syndrome that accompanies a number of other diseases of the hypothalamic-pituitary zone, endocrine diseases, pathology of internal organs, lesions of the central nervous system, and can also be iatrogenic (drug-induced HPRL). HPRL is more common in women but can also occur in men with various reproductive and sexual health disorders. Many drugs can cause HPRL. In order to establish the frequency of occurrence of this problem in the clinical practice of an internist, an analysis of the literature was carried out. Articles related to HPRL induced by specific types of drugs were reviewed. This review presents the current views of domestic and foreign authors on the causes and mechanisms of development of HPRL.