Drug-induced acute interstitial nephritis in renal allografts: Histopathologic features and clinical course in six patients

Josephson, Michelle A.; Chiu, May; Woodle, E. Steve; Thistlethwaite, J. Richard; Haas, Mark

doi:10.1016/s0272-6386(99)70083-1

Cited by 35 publications

(14 citation statements)

References 19 publications

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“…It seems reasonable to additionally screen patients from groups 1‐3 for other atypical organisms (chlamydia, gonococci, mycobacteria, and possibly herpes simplex virus). However, non‐infectious causes such as drug‐induced acute interstitial nephritis, renal allograft rejection, or polyomavirus nephropathy are important differential diagnoses in patients from group 3, and often these patients will require an allograft biopsy.…”

Section: Discussionmentioning

confidence: 99%

Ureaplasma and Mycoplasma in kidney allograft recipients—A case series and review of the literature

Gerber

Gaspert

Braghetti

et al. 2018

Transplant Infectious Dis

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Ureaplasma urealyticum and Mycoplasma hominis are common inhabitants of the human genital tract. Increasingly, serious and sometimes fatal infections in immunocompromised hosts have been reported, highlighting their pathogenic potential. We reviewed the clinical impact of positive Ureaplasma spp. and Mycoplasma spp. urine cultures in 10 renal allograft recipients who presented with sterile leukocyturia. Five recipients remained asymptomatic. Five patients were symptomatic with dysuria or pain at the graft site. Three patients developed biopsy-proven acute graft pyelonephritis with graft dysfunction. One of these patients additionally showed a renal abscess as demonstrated by magnetic resonance imaging (MRI). All were successfully treated. A literature search revealed a substantial number of case reports with severe and sometimes fatal Ureaplasma spp. or Mycoplasma spp. infections in immunocompromised patients. Colonization rate is high in renal transplant patients. A subset of patients is at risk for invasive disease.

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Section: Discussionmentioning

confidence: 99%

Ureaplasma and Mycoplasma in kidney allograft recipients—A case series and review of the literature

Gerber

Gaspert

Braghetti

et al. 2018

Transplant Infectious Dis

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“…Their graft function was improved after anti‐infection therapy. Other than infective factors, rare cases of GIN have been described in renal allografts in association with the recurrence of sarcoidosis and medication . Collectively, these reports indicated that infection was the main causative factor of GIN in renal allografts, which differed from the native kidney.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous tubulointerstitial nephritis in a renal allograft: three cases report and review of literature

Hotta

Fukasawa

Sasaki

et al. 2012

Clinical Transplantation

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nephritis in a renal allograft: three cases report and the review of literature.Abstract: Granulomatous interstitial nephritis (GIN) is a rare histologic diagnosis in renal allografts. We report three cases with GIN. Case 1: a 37-yr-old woman received a kidney from her mother. On follow-up 15 months later, serum creatinine was increased and a graft biopsy showed epithelioid granuloma in the center of massive mononuclear cell infiltration. She had presented with refractory urinary tract infection treated with antibiotics before biopsy. The case was presumed to be GIN associated with UTI or hypersensitivity to medication. Case 2: a 47-yr-old woman received a second graft from a non-heart-beating donor. A protocol graft biopsy was performed six months after transplantation and showed several granulomatous nodules. She was followed closely without therapy. Case 3: a 27-yr-old woman received an ABOincompatible kidney from her father. A protocol graft biopsy was performed three months after transplantation and showed granulomatous reaction with severe mononuclear cell infiltration. She received steroid pulse therapy. The two latter patients had no obvious factor contributing to GIN. Therefore, they were presumed to have idiopathic GIN. Infection is considered to be the main causative factor of GIN in renal allografts. This paper describes rare cases of GIN that had no infectious episode in the renal allografts.

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“…The true incidence of nephrotoxicity is poorly described in the literature, which is limited to case series and reports often involving patients with underlying renal abnormalities. [45][46][47] This misconception of high rates of nephrotoxicity associated with TMP-SMX use is enhanced by the fact that earlier generation, less-soluble sulfonamides (e.g., sulfadiazine) used in very high doses were associated with crystalluria. 48 However, crystalluria does not usually occur with newer agents, including sulfamethoxazole.…”

Section: Trimethoprim-sulfamethoxazolementioning

confidence: 99%

Revisiting “Older” Antimicrobials in the Era of Multidrug Resistance

et al. 2011

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Infections due to multidrug-resistant (MDR) organisms continue to increase, and the antimicrobial pipeline remains unacceptably lean. Given this challenge, it is has become necessary to use older antimicrobials for treatment of MDR pathogens despite concerns regarding toxicity and the lack of clinical efficacy data. In some cases, older antimicrobials offer potential advantages compared with new agents, including lower cost and better in vitro activity. In this review, we focus on the pharmacology, in vitro activity, and clinical experience of older agents, including colistin, minocycline, trimethoprim-sulfamethoxazole, and fosfomycin. We also discuss some new antimicrobial agents that are used to treat MDR pathogens. As MDR pathogens continue to outpace the development of new antimicrobials, it will become imperative to develop strategies regarding the optimal use of older agents in terms of monotherapy versus combination therapy, dosing regimens, and treatment of invasive infections caused by these pathogens.

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Drug-induced acute interstitial nephritis in renal allografts: Histopathologic features and clinical course in six patients

Cited by 35 publications

References 19 publications

Ureaplasma and Mycoplasma in kidney allograft recipients—A case series and review of the literature

Ureaplasma and Mycoplasma in kidney allograft recipients—A case series and review of the literature

Granulomatous tubulointerstitial nephritis in a renal allograft: three cases report and review of literature

Revisiting “Older” Antimicrobials in the Era of Multidrug Resistance

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