Granulomatous tubulointerstitial nephritis in a renal allograft: three cases report and review of literature

Hotta, Kiyohiko; Fukasawa, Yuichiro; Sasaki, Hajime; Seki, Toshimori; Terabe, Masaki; Harada, Hiroshi

doi:10.1111/j.1399-0012.2012.01643.x

Cited by 12 publications

(11 citation statements)

References 15 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, there was a review of GIN in allografts. [11] The age of patients was lower in our patients than these studies. While in our patients tuberculosis was a significant cause of GIN, in the previous studies dugs and sarcoidosis were leading causes and a higher percentage of (42.8%, 6 out of 14) required renal replacement therapy (RRT) in our patients [Table 2].…”

Section: Discussioncontrasting

confidence: 63%

Granulomatous interstitial nephritis: Our experience of 14 patients

et al. 2013

View full text Add to dashboard Cite

Granulomatous interstitial nephritis (GIN) is a rare condition. Drugs, infections, immune processes, and foreign body reaction are the main causes. We identified a total of 14 patients with GIN during a period of 13 years in 2798 renal biopsies. There were 8 males and 6 females in the age range of 20-70 (mean 35 ± 12) years. The serum creatinine at presentation was 6.7 ± 3.8 (range: 2.3-14.7) mg/dl. In nine patients tuberculosis was the causative agent. Drugs (n = 2) and Wegener's granulomatosis (n = 1) were other etiologies. Systemic lupus erythematosis (SLE) and Immunoglobulin A nephropathy (IgAN) were seen in one patient each. Patients with tuberculosis were treated with antituberculous therapy and three of them improved. Four out of six patients who required dialysis at presentation remained dialysis dependent, one of whom underwent renal transplantation. Two patients progressed to end stage renal disease after 7 years and 9 years each. The patients with drug induced GIN had improvement in renal function after prednisolone treatment. Patients with SLE, and Wegener's granulomatosis responded to immunosuppression. Patient with IgAN was on conservative management. Finally, six patients were on conservative management for chronic renal failure.

show abstract

Section: Discussioncontrasting

confidence: 63%

Granulomatous interstitial nephritis: Our experience of 14 patients

et al. 2013

View full text Add to dashboard Cite

show abstract

“…1 Limited studies are published in literature on this subject including both native and allograft renal biopsies. [4][5][6][7][8] …”

Section: Introductionmentioning

confidence: 99%

Renal failure due to granulomatous interstitial nephritis in native and allograft renal biopsies: experience from a tertiary care hospital

et al. 2014

View full text Add to dashboard Cite

Granulomatous interstitial nephritis is a rare cause of renal failure in both native and allograft renal biopsies. Drugs and sarcoidosis are the commonest causes of granulomatous interstitial nephritis as reported in Western countries. Unlike the west, tuberculosis is the commonest cause of granulomatous interstitial nephritis in Indian subcontinent. The etiological factors, clinical course, glomerular and tubulointerstitial changes associated with granulomatous interstitial nephritis have been analyzed in the present study along with the outcome in patients with granulomatous interstitial nephritis.

show abstract

“…Renal allograft granulomatous interstitial nephritis is rare, presenting in <0.5% of kidney transplant biopsies . As expected in immunosuppressive states, the vast majority of cases are secondary to infections, among which mycobacterial and fungal etiologies predominate .…”

Section: Discussionmentioning

confidence: 99%

Granulomatous inflammation in BK polyomavirus–associated nephropathy

Zhang

Ahmed

Haririan

et al. 2018

Transplant Infectious Dis

View full text Add to dashboard Cite

Evolving BK polyomavirus-associated nephropathy (BKPyVAN) is characterized by tubulointerstitial inflammation that closely resembles acute T-cell-mediated allograft rejection if tubulitis is significant. The cellular composition of the inflammation varies during the course of BKPyVAN, and clusters of plasma cells may herald resolution of the infection. Less commonly, BKPyVAN can present with a predominance of histiocytes and granuloma formation. Granulomatous interstitial nephritis is uncommon in biopsies of either native or transplant kidneys. In both settings, this distinctive type of inflammatory response requires a systematic approach with careful clinicopathological assessment to determine its etiology. We present three patients with granulomatous BKPyVAN in the first year post-transplantation. These allograft biopsies at 4, 6, and 12 months post-transplant exemplify spontaneously resolving BKPyVAN, resolving infection after immunosuppression reduction, and early BKPyVAN, respectively. In immunosuppressed patients, BKPyVAN should be added to the relatively broad differential diagnosis of granulomatous tubulointerstitial nephritis.

show abstract

Granulomatous tubulointerstitial nephritis in a renal allograft: three cases report and review of literature

Cited by 12 publications

References 15 publications

Granulomatous interstitial nephritis: Our experience of 14 patients

Granulomatous interstitial nephritis: Our experience of 14 patients

Renal failure due to granulomatous interstitial nephritis in native and allograft renal biopsies: experience from a tertiary care hospital

Granulomatous inflammation in BK polyomavirus–associated nephropathy

Contact Info

Product

Resources

About