Drug Embedded PVP Coated Magnetic Nanoparticles for Targeted Killing of Breast Cancer Cells

Rose, P. Arsula; Praseetha, P.K.; Bhagat, Madhulika; Alexander, P.; Abdeen, Sunitha; Chavali, Murthy

doi:10.7785/tcrt.2012.500333

Cited by 49 publications

(20 citation statements)

References 20 publications

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“…From the results, the UV-Vis spectrum analysis confirmed that the drug loading efficiency to the PVP coated iron oxide nanoparticles with the methanolic extract of the Syzygium aromaticum showed more efficiency. Similar types of results were observed using different plant extracts respectively [24,25]. So, these results were correlated with previous observations.…”

Section: Uv-visible Spectroscopysupporting

confidence: 91%

Biosynthesis and Characterization of Iron Oxide Nanoparticles via Syzygium aromaticum Extract and Determination of Its Cytotoxicity against Human Breast Cancer Cell Lines

Thenmozhi¹,

Rasajna²,

Rajesh³

et al. 2019

JNST

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Magnetic iron oxide nanoparticles exhibit many interesting properties due to their surface chemistry and they can be exploited in biomedical and technological applications. The iron oxide nanoparticles (FeO NPs) using ferric chloride, ferrous chloride, PVP (Poly Vinyl Pyrolidone) and Syzygium aromaticum extract were successfully synthesized by wet-chemical co-precipitation method. The PVP coated FeO NPs and S. aromaticum loaded to PVP coated FeO NPs were systematically characterized by using expository tools. UV-Visible spectroscopy showed the maximum absorbance at 480 nm and 554 nm due to the excitation of surface plasmon vibrations in the FeO NPs formation. Fourier transform infrared (FT-IR) spectrum showed the presence of functional groups of in the form of various band positions and this study confirmed that phenols and primary amines were majorly present. DLS studies revealed narrow size of particles i.e., 399.8 nm and 190.1 nm. Particle size distribution was showed at 256 nm and 153 nm for these samples and zeta potential values were observed at-23.7 and-18.8 mV with greater stability. The X-ray diffraction (XRD) analysis is in good agreement with a high degree of crystallographic nature of particles and the average particle size was found to be 23 nm and 29 nm using Scherrer equation. FT-Raman spectrum showed three main characteristic peaks. The scope of this study was extended by examining the cytotoxicity of PVP coated FeO NPs and S. aromaticum loaded PVP coated FeO NPs on human breast (MCF-7) cancer cell lines. The results suggest that the S. aromaticum loaded FeO NPs acts as a potential anti-cancer agent and are a promising research field for lots of biomedical applications particularly for breast cancer studies.

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Section: Uv-visible Spectroscopysupporting

confidence: 91%

Biosynthesis and Characterization of Iron Oxide Nanoparticles via Syzygium aromaticum Extract and Determination of Its Cytotoxicity against Human Breast Cancer Cell Lines

Thenmozhi¹,

Rasajna²,

Rajesh³

et al. 2019

JNST

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“…The latter is further polymer functionalized on the basis of previously prepared IONPs. Todate, dextran, chitosan, alginate, polyethylene glycol (PEG), polyvinyl alcohol (PVA), polydopamine (PDA), polysaccharide, polyethylenimine, polyvinylpyrrolidone (PVP), poly acid polyetherimide, and polyamidoamine (PAMAM) are the most commonly used polymers for the surface modification of IONPs ( Table 3 ) [ 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 ].…”

Section: Surface Modification Of Magnetic Iron Oxide Nanoparticlesmentioning

confidence: 99%

Surface Modification of Magnetic Iron Oxide Nanoparticles

et al. 2018

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Functionalized iron oxide nanoparticles (IONPs) are of great interest due to wide range applications, especially in nanomedicine. However, they face challenges preventing their further applications such as rapid agglomeration, oxidation, etc. Appropriate surface modification of IONPs can conquer these barriers with improved physicochemical properties. This review summarizes recent advances in the surface modification of IONPs with small organic molecules, polymers and inorganic materials. The preparation methods, mechanisms and applications of surface-modified IONPs with different materials are discussed. Finally, the technical barriers of IONPs and their limitations in practical applications are pointed out, and the development trends and prospects are discussed.

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“…Up to now, PVP has been used in the pharmaceutical and biomedical fields to develop different drug delivery systems, such as oral, topical, transdermal, and ocular administration. Besides, PVP is also useful in the delivery of genes [8][9][10][11][12] or can be coupled with metal particles for regenerative medicine [13][14][15] and targeted-delivery [16,17]. Therefore, PVP results to also be a very versatile polymer.…”

Section: Introductionmentioning

confidence: 99%

The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

2020

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Polyvinylpyrrolidone (PVP) is a hydrophilic polymer widely employed as a carrier in the pharmaceutical, biomedical, and nutraceutical fields. Up to now, several PVP-based systems have been developed to deliver different active principles, of both natural and synthetic origin. Various formulations and morphologies have been proposed using PVP, including microparticles and nanoparticles, fibers, hydrogels, tablets, and films. Its versatility and peculiar properties make PVP one of the most suitable and promising polymers for the development of new pharmaceutical forms. This review highlights the role of PVP in drug delivery, focusing on the different morphologies proposed for different polymer/active compound formulations. It also provides detailed information on active principles and used technologies, optimized process parameters, advantages, disadvantages, and final applications.

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Drug Embedded PVP Coated Magnetic Nanoparticles for Targeted Killing of Breast Cancer Cells

Cited by 49 publications

References 20 publications

Biosynthesis and Characterization of Iron Oxide Nanoparticles via Syzygium aromaticum Extract and Determination of Its Cytotoxicity against Human Breast Cancer Cell Lines

Biosynthesis and Characterization of Iron Oxide Nanoparticles via Syzygium aromaticum Extract and Determination of Its Cytotoxicity against Human Breast Cancer Cell Lines

Surface Modification of Magnetic Iron Oxide Nanoparticles

The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

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