Drug-eluting stents: results, promises and problems

Hoeven, Barend L. van der; Pires, Nuno; Warda, Hazem M.; Oemrawsingh, Pranobe V.; Vlijmen, Bart J.M. van; Quax, Paul H.A.; Schalij, Martin J.; Wall, Ernst E. van der; Jukema, J. Wouter

doi:10.1016/j.ijcard.2004.01.021

Cited by 174 publications

(100 citation statements)

References 61 publications

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“…As a proposed improvement on BMS, the first generation of drug-eluting stents (DESs) consisted of a metal backbone and a permanent, non-absorbable polymer coating to house a drug of choice [14]. While DESs offered control and localization for drug release to the injured vessel, incidences of hypersensitivity, heart attack and even death remained problematic [5].…”

Section: Current Stents and Associated Issuesmentioning

confidence: 99%

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Govindarajan

Shandas

2014

Polymers

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Abstract:The search for a single material with ideal surface properties and necessary mechanical properties is on-going, especially with regard to cardiovascular stent materials. Since the majority of stent problems arise from surface issues rather than bulk material deficiencies, surface optimization of a material that already contains the necessary bulk properties is an active area of research. Polymers can be surface-modified using a variety of methods to increase hemocompatibilty by reducing either late-stage restenosis or acute thrombogenicity, or both. These modification methods can be extended to shape memory polymers (SMPs), in an effort to make these materials more surface compatible, based on the application. This review focuses on the role of surface modification of materials, mainly polymers, to improve the hemocompatibility of stent materials; additional discussion of other materials commonly used in stents is also provided. Although shape memory polymers are not yet extensively used for stents, they offer numerous benefits that may make them good candidates for next-generation stents. Surface modification techniques discussed here include roughening, patterning, chemical modification, and surface modification for biomolecule and drug delivery.

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Section: Current Stents and Associated Issuesmentioning

confidence: 99%

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Govindarajan

Shandas

2014

Polymers

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“…Drug releasing stents are an effective means for treatment in this area [115]. However, the long term effects are unclear and bypassing the need for cytostatic drugs or invasive modalities would be beneficial [116]. Interestingly, smooth muscle migration and proliferation can be targeted specifically by PDT agents [117].…”

Section: Restenosismentioning

confidence: 99%

Platelets, photosensitizers, and PDT

Senge

Radomski

2013

Photodiagnosis and Photodynamic Therapy

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SummaryPhotodynamic therapy (PDT) has both direct cell and indirect vascular effects. Both are well established and the latter has given rise to specifically target angiogenesis in PDT treatments. While the vascular effects are well understood, further advances in antiangiogenesis require a detailed understanding of PDT effects at the microvasculature level. Although some of the earliest investigations of PDT noted effects on platelet aggregation the importance of their interaction with endothelial cells and the crucial role of various signaling pathways is only now emerging. This review aims to give a general overview of PDT related studies on platelets, vascular effects, and their interaction with endothelial cells to indicate the potential for studies in this area.Abbreviations: ALA --aminolevulinic acid; AMD -age-related macular degeneration; ANET -anti-neovascular therapy; BGF -basic fibroblast growth factor; DHEdihaematoporphyrin ether; EDRF -endothelium-derived relaxing factor; epithelial growth factor -EGF; HIF-1 -hypoxia-inducible factor 1; HpD -haematoporphyrin derivative; IL -interleukin; PAF -platelet activating factor; PDT -photodynamic therapy; PS -photosensitizer; transforming growth factor 1 -TGF-1; TNF -tumor necrosis factor.

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“…Temel olarak neointimal hiperplazinin bir sonucu olarak ortaya çıkar [12][13][14]. Çıplak metal stentlerde klinik olarak semptomatik restenoz oranı %20 -40'lara ulaşırken ilaç salınımlı stentlerde ilk sonuçlar 1 yıla kadar erken ve orta vadeli stent restenozunda belirgin düşüş bildirmektedir [12][13][14][15].…”

Section: Koroner Arter Stentlerinin Değerlendirilmesiunclassified

Koroner Arter Stentlerinin Değerlendirilmesi

Oncel¹,

Öncel²

2013

Trd Sem

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Drug-eluting stents: results, promises and problems

Cited by 174 publications

References 61 publications

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Platelets, photosensitizers, and PDT

Koroner Arter Stentlerinin Değerlendirilmesi

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