Drug-drug and drug-solvent interaction studies of Chloroquine phosphate, Acefylline piperazine and Gentamicin sulfate in polymeric systems

Masood, Summyia; Rehman, Warda; Begum, Sabira; Khan, Zulfiqar Ali; Gulnar, Lubna

doi:10.1016/j.arabjc.2020.05.030

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…The Chloroquine incorporated Zn particles and PEG/PLA may be linked by various interactions such as Hydrophobic-hydrophobic, Ion-dipole, H-bond, and Dipole-dipole as shown in figure 3 A. Among all interactions, solute-hydrophobic and hydrophobic-hydrophobic interactions are dominant over solute-hydrophilic and hydrophilic-hydrophobic interactions ( Masood et al, 2020 ). Hydrophobic (e.g., PLA, etc.)…”

Section: (I) Copolymer Micellesmentioning

confidence: 99%

Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles

Manuja

Kumar

Chhabra

2023

Arabian Journal of Chemistry

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Section: (I) Copolymer Micellesmentioning

confidence: 99%

Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles

Manuja

Kumar

Chhabra

2023

Arabian Journal of Chemistry

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“…The collective effect of drug-solvent interactions reflects the partial molar volume of the drug. The partial molar volume (ϕ ) and experimental slope S v have been computed with the help of apparent molar volume by using the following Masson equation [20].…”

Section: Volumetric Propertiesmentioning

confidence: 99%

Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods

et al. 2022

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The examination of a drug in water and other aqueous systems gives insight into the chemistry of biological systems. This work aims to study the physico-chemical properties of chlorpheniramine maleate (drug) in water and aq-MeOH/EG (mono/dihydric alcohols) systems at different temperatures by using different techniques. Densities and viscosities of chlorpheniramine maleate in water and also in MeOH/EG aqueous solutions have been measured over a temperature range of 298.15 to 318.15 K. Number of several parameters, i.e., apparent molar volume (ϕv), partial molar volume (ϕvo), Hepler’s constant (∂CΡ/∂Ρ)T, Falkenhagen coefficient (A), and Jones-Dole coefficient (B) have been calculated by using experimentally measured density and viscosity values. The mentioned calculated parameters were found to be valuable in perceiving drug-drug and drug-solvent interactions. Moreover, one of the liquid chromatographic techniques such as RP-HPLC has also been performed, and the outcomes supported the conclusion procured from the volumetric and viscometric studies. Drug interactions help to understand their behavior in different solvent systems during drug development.

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“…Acefylline piperazine is one of the N-7 substituted derivatives of theophylline as shown in Fig. 1, and serves as a diuretic, cardiac stimulant, anti-asthmatic and bronchodilator [5,6]. Controlled drug delivery (CDD) has been considered as an entity that is targetspecific and delivers a drug at a constant desired rate for a long period of time (at least 12 h) [6].…”

Section: Introductionmentioning

confidence: 99%

“…1, and serves as a diuretic, cardiac stimulant, anti-asthmatic and bronchodilator [5,6]. Controlled drug delivery (CDD) has been considered as an entity that is targetspecific and delivers a drug at a constant desired rate for a long period of time (at least 12 h) [6]. Controlled release technology along with drug delivery has become a powerful tool and has received the great attention of chemists and chemical engineers who are contributing to the betterment of human health care [7].…”

Section: Introductionmentioning

confidence: 99%

Measurement of Acefylline Piperazine Interaction and Dissociation Constants in Polymer Solvent Systems

Masood,

Rehman,

Naseem

et al. 2023

PJAEC

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In this study the physicochemical interactions of acefylline piperazine drug (APD) were examined in aqueous and aqueous polymer systems viz., aqueous polyethylene glycol (1.0 %w/v) and aqueous polyvinyl pyrrolidone (1.0% w/v). The study was carried within the concentration ranges from 2.0×10-2 to 10.0 ×10-2 mol/dm3 at different temperatures (293.15 to 318.15 K with the difference of 5 K). Various analytical methods such as conductometric, refractometry, and liquid chromatographic (RP-HPLC) were applied. In order to observe the interaction of APD, o m was calculated to evaluate the structural influence of polymers on the mobility of solute (APD) at different temperatures. α, Kd and Walden product of APD were also assessed in aqueous polyethylene glycol and aqueous polyvinyl pyrrolidone. Solvation was observed by Walden's product showing strong solvation of APD in water-soluble polymer systems. Thermodynamic parameters for APD such as * E , ΔG*, ΔH*and ΔS* have also been evaluated as a function of temperature to determine the exo/endothermic nature of the drug dissociation process. Specific refraction, molar refraction and polarizability of APD in aqueous and aqueous polymer systems were calculated using the Lorentz-Lorentz equation and various interactions were interpreted. Drug's compatibility studies were also performed by HPLC in aqueous and aqueous polymer systems.

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Drug-drug and drug-solvent interaction studies of Chloroquine phosphate, Acefylline piperazine and Gentamicin sulfate in polymeric systems

Cited by 8 publications

References 29 publications

Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles

Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles

Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods

Measurement of Acefylline Piperazine Interaction and Dissociation Constants in Polymer Solvent Systems

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