Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles

Manuja, Anju; Kumar, Balvinder; Chhabra, Dharvi

doi:10.1016/j.arabjc.2022.104468

Cited by 7 publications

(7 citation statements)

References 97 publications

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“…Polymer micelles are NPs made of polymeric materials with a spherical or oval shape and size, usually tens to hundreds of nanometers in diameter 107,108 . Micelles are composed of polymer chain segments that self‐assemble to form a core and shell structure, with the core usually composed of hydrophobic polymers and the shell composed of hydrophilic polymers 109,110 .…”

Section: Overview Of Npsmentioning

confidence: 99%

“…Polymer micelles are NPs made of polymeric materials with a spherical or oval shape and size, usually tens to hundreds of nanometers in diameter. 107 , 108 Micelles are composed of polymer chain segments that self‐assemble to form a core and shell structure, with the core usually composed of hydrophobic polymers and the shell composed of hydrophilic polymers. 109 , 110 This structure gives micelles dual hydrophilic and hydrophobic properties, making them useful for a wide range of applications such as drug delivery and material preparation.…”

Section: Overview Of Npsmentioning

confidence: 99%

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Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Liu,

Yang,

et al. 2024

CNS Neurosci Ther

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Gliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood–brain barrier and the occurrence of the drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In recent years, the rapid development of nanotechnology has brought new hope for the treatment of tumors. Nanoparticles (NPs) have shown great potential in tumor therapy due to their unique properties such as light, heat, electromagnetic effects, and passive targeting. Furthermore, NPs can effectively load chemotherapeutic drugs, significantly reduce the side effects of chemotherapeutic drugs, and improve chemotherapeutic efficacy, showing great potential in the chemotherapy of glioma. In this article, we reviewed the mechanisms of glioma drug resistance, the physicochemical properties of NPs, and recent advances in NPs in glioma chemotherapy resistance. We aimed to provide new perspectives on the clinical treatment of glioma.

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Section: Overview Of Npsmentioning

confidence: 99%

Section: Overview Of Npsmentioning

confidence: 99%

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Liu,

Yang,

et al. 2024

CNS Neurosci Ther

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“…It is noteworthy that most of the papers available in literature deal with the use of Zn 2+ ions as antiviral agents, rather than ZnO NSs, possibly in combination with other molecules like lactoferrin, heparin, etc. − Zinc ions can penetrate cell walls (especially when driven by ionophores), augmenting the intracellular Zn 2+ concentration and subsequently impairing virus replication . Bhatti and DeLong recently reviewed the antiviral application of different nanomaterials, including ZnO NSs: in that paper, ROS generated through photocatalytic reactions driven by UV–Vis light on ZnO NSs are indicated as the main species responsible for damaging of the viral envelopes, interfering with viral entry and replication …”

Section: Antimicrobial Applicationsmentioning

confidence: 99%

“…264−274 Zinc ions can penetrate cell walls (especially when driven by ionophores), augmenting the intracellular Zn 2+ concentration and subsequently impairing virus replication. 275 Bhatti and DeLong 276 recently reviewed the antiviral application of different nanomaterials, including ZnO NSs: in that paper, ROS generated through photocatalytic reactions driven by UV−Vis light on ZnO NSs are indicated as the main species responsible for damaging of the viral envelopes, interfering with viral entry and replication. 249 Indeed, before the COVID-19 pandemic, the use of ZnO NSs as antiviral agents was not as massively diffused as that of their antimicrobial applications.…”

Section: Antibacterial Applicationsmentioning

confidence: 99%

Synthesis and Antimicrobial Applications of ZnO Nanostructures: A Review

Izzi

Sportelli

Torsi

et al. 2023

ACS Appl. Nano Mater.

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ZnO nanostructures (ZnO NSs) are able to provide significant antimicrobial activity, ensuring high biocompatibility, good chemical stability, and low toxicity. Such versatility has led to great success of this nanomaterial for antibacterial, antifungal, and, more recently, antiviral applications. However, methods for the preparation of ZnO NSs must be properly selected for their end use. Moreover, ZnO NSs can also be cytotoxic to some extent. In this context, this review emphasizes some aspects relevant to the preparation as well as to the antimicrobial use of ZnO NSs. In particular, a brief overview of the sol–gel, hydrothermal, biogenic, and electrochemical approaches proposed for their synthesis is presented, highlighting advantages/drawbacks of each route in terms of scalability, simplicity, and efficacy. Next, the application of ZnO NSs in several fields is reported. This is followed by a discussion of the antimicrobial role of ZnO NSs, where antimicrobial mechanisms of action, possible cell resistance, and cytotoxicity of ZnO NSs are highlighted. We also discuss the role of ZnO NSs against different biothreats, such as bacteria and viruses. The future of such nanomaterials in this application field is addressed in the final part.

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“…Both CQ and HCQ have been successfully used for the treatment of autoimmune diseases like rheumatic diseases [2,6] and systemic lupus erythematosus [6][7][8]. Recently, they have also been tested for the treatment and prophylactics of viral infections, including Zika virus [9,10], human immunodeficiency virus (HIV) [11,12], and COVID-19, although the obtained results were inconsistent or negligible and revealed many side effects [13,14].…”

Section: Introductionmentioning

confidence: 99%

Chloroquine and Chemotherapeutic Compounds in Experimental Cancer Treatment

Agalakova

2024

IJMS

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Chloroquine (CQ) and its derivate hydroxychloroquine (HCQ), the compounds with recognized ability to suppress autophagy, have been tested in experimental works and in clinical trials as adjuvant therapy for the treatment of tumors of different origin to increase the efficacy of cytotoxic agents. Such a strategy can be effective in overcoming the resistance of cancer cells to standard chemotherapy or anti-angiogenic therapy. This review presents the results of the combined application of CQ/HCQ with conventional chemotherapy drugs (doxorubicin, paclitaxel, platinum-based compounds, gemcitabine, tyrosine kinases and PI3K/Akt/mTOR inhibitors, and other agents) for the treatment of different malignancies obtained in experiments on cultured cancer cells, animal xenografts models, and in a few clinical trials. The effects of such an approach on the viability of cancer cells or tumor growth, as well as autophagy-dependent and -independent molecular mechanisms underlying cellular responses of cancer cells to CQ/HCQ, are summarized. Although the majority of experimental in vitro and in vivo studies have shown that CQ/HCQ can effectively sensitize cancer cells to cytotoxic agents and increase the potential of chemotherapy, the results of clinical trials are often inconsistent. Nevertheless, the pharmacological suppression of autophagy remains a promising tool for increasing the efficacy of standard chemotherapy, and the development of more specific inhibitors is required.

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Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles

Cited by 7 publications

References 97 publications

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Synthesis and Antimicrobial Applications of ZnO Nanostructures: A Review

Chloroquine and Chemotherapeutic Compounds in Experimental Cancer Treatment

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