Drug distribution evaluation using FT-IR imaging on the surface of a titanium alloy coated with zinc titanate with potential application in the release of drugs for osteoporosis

Sandomierski, Mariusz; Jakubowski, Marcel; Ratajczak, Maria; Voelkel, Adam

doi:10.1016/j.saa.2022.121575

Cited by 14 publications

(6 citation statements)

References 43 publications

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“…Local delivery of active substances is a rapidly developing field of controlled drug delivery. Local delivery is used, for example, in the delivery of drugs from the surface of implants and the delivery of drugs and antibacterial substances in eye diseases 13–16 . Taking into account the above‐mentioned disadvantages during 6MP therapy, there is a great need to create an appropriate delivery system for this drug.…”

Section: Introductionmentioning

confidence: 99%

“…Local delivery is used, for example, in the delivery of drugs from the surface of implants and the delivery of drugs and antibacterial substances in eye diseases. [13][14][15][16] Taking into account the above-mentioned disadvantages during 6MP therapy, there is a great need to create an appropriate delivery system for this drug. There are several papers in which an attempt was made to synthesize such carriers.…”

Section: Introductionmentioning

confidence: 99%

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Zinc‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine

Jakubowski,

Majchrzycki,

Zarkov

et al. 2024

J Biomed Mater Res

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Abstract6‐Mercaptopurine (6MP) is commonly used in the treatment of acute lymphoblastic leukemia as an important agent in maintenance therapy. Despite its therapeutic benefits, 6MP has some limitations during therapy. Taking into account the disadvantages during 6MP therapy, there is a great need to create an appropriate delivery system for this drug. 6MP contains in its structure nitrogen and sulfur atoms capable of forming coordination compounds with metal ions, for example zinc. Therefore, in this work, we prepared biocompatible hydroxyapatite (HAp) doped with zinc ions, and used it as a carrier for 6MP. Doped HAp has not been used as a carrier for this drug before. The work proved that the prepared carrier‐drug system has a particle size of about 130 nm, which indicates its potential for intravenous delivery. In addition, in an acidic environment (imitating cancer cells), the carrier agglomerates allow targeted release of the drug. The drug is evenly distributed, which indicates that the doses released from it will always be comparable. The release of the drug in a neutral environment is long‐lasting in controlled doses, whereas in an acidic environment it is immediate. The obtained results indicate the high potential of the material in both slow‐release and cancer‐targeted release of 6MP.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zinc‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine

Jakubowski,

Majchrzycki,

Zarkov

et al. 2024

J Biomed Mater Res

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“…Many years of observations on titanium and its alloys have shown that they have a long-term significance for medicine [ 9 ]. These materials can be implanted into a patient’s body for periods in excess of twenty-five years.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Magnesium and Zinc Forms of Sodalite Coatings on Ti6Al4V ELI for Potential Application in the Release of Drugs for Osteoporosis

et al. 2023

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Osteoporosis is the most common metabolic disease of the skeletal system and is characterized by impaired bone strength. This translates into an increased risk of low-energy fractures, which means fractures caused by disproportionate force. This disease is quite insidious, its presence is usually detected only at an advanced stage, where treatment with pharmaceuticals does not produce sufficient results. It is obligatory to replace the weakened bone with an implant. For this reason, it is necessary to look at the possibilities of surface modification used in tissue engineering, which, in combination with the drugs for osteoporosis, i.e., bisphosphonates, may constitute a new and effective method for preventing the deterioration of the osteoporotic state. To achieve this purpose, titanium implants coated with magnesium or zinc zeolite were prepared. Both the sorption and release profiles differed depending on the type of ion in the zeolite structure. The successful release of risedronate from the materials at a low level was proven. It can be concluded that the proposed solution will allow the preparation of endoprostheses for patients with bone diseases such as osteoporosis.

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“…This is due to the fact that such layers have previously supported bone growth (e.g., ZIF-8 layer) [14]. In the next and last step of the modification, the drug was attached by a coordination bond (between the Zn and RSD molecules) [15]. The use of zinc ions for the drug sorption process was based on the results of studies on zinc zeolites [16], where the obtained Zeo-Zn-RSD coating was characterized by good strength properties as well as the parameters (amount) of the drug released from the surface.…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium

Szczuka,

Sandomierski,

Voelkel

et al. 2023

Materials

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With the simultaneous increase in the number of endoprostheses being performed, advances in the field of biomaterials are becoming apparent—whereby the materials and technologies used to construct implants clearly improve the implants’ quality and, ultimately, the life of the patient after surgery. The aim of this study was to modify the titanium alloy Ti6Al4V ELI used in the construction of hip joint endoprostheses. This is why the continuous development of biomaterials is so important. This paper presents the results of research for a new application of polymer poly(ethylene-alt-maleic anhydride) as a drug release layer, placed on the surface of a titanium alloy. The obtained layers were analyzed using Raman spectroscopy (spectra and maps), Fourier transform infrared spectroscopy (spectra and maps), contact angle measurements as well as scanning electron microscopy and energy dispersive spectroscopy imaging and topography analysis. The results confirmed that the polymer layer obtained on the plate surface after the alkali heat treatment process is much better—it binds much more polymer and thus the applied drug. In addition, a longer and more gradual release of the drug was observed for the alkali heat treatment modification than for H2O2 solution.

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Drug distribution evaluation using FT-IR imaging on the surface of a titanium alloy coated with zinc titanate with potential application in the release of drugs for osteoporosis

Cited by 14 publications

References 43 publications

Zinc‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine

Zinc‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine

Characterization of Magnesium and Zinc Forms of Sodalite Coatings on Ti6Al4V ELI for Potential Application in the Release of Drugs for Osteoporosis

Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium

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