Drug Discovery from Natural Sources

Newman, David J.

doi:10.1007/s40495-023-00313-3

Cited by 5 publications

(2 citation statements)

References 96 publications

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“…[1][2][3] Over the years, different organisms have been considered as starting points of the Nature-Aided Drug Discovery (NADD) process, e.g., plants, lichens, animals, and microorganisms, either terrestrial or marine. 4 The successes achieved pursuing this approach are many and well-known. 5 The wide chemical diversity is the strength of natural products (NPs), which allows molecules to be obtained with various mechanisms of action and, therefore, suitable for various fields of application.…”

Section: Introductionmentioning

confidence: 99%

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Cavalloro,

Marrubini,

Rossino

et al. 2024

Green Chem.

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Section: Introductionmentioning

confidence: 99%

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Cavalloro,

Marrubini,

Rossino

et al. 2024

Green Chem.

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“…the distribution of AMPs according to their deriving life kingdom is graphically represented. These peptides can be naturally produced by organisms as a mechanism of defense against pathogens and other threats in biological endogenous processes, but like other bioactive peptides, can also be obtained through fermentation, digestion, extraction, and hydrolysis[107][108][109]. Peptides with biological activity can also be synthesized based on a predicted biological function of the sequence and its characteristics, taking the structure of natural peptides as a model but not directly derived from them[110][111][112].…”

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confidence: 99%

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Franca-Oliveira,

Hernández-Ledesma,

Martinez-Rodriguez

2024

BCHD

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The infection and chronic inflammatory response generated by Helicobacter pylori is a global health concern. This pathogen is characterized as a major risk factor in the development of gastric cancer and other diseases. Conventional eradication therapies are based on antibiotic regimens and as a consequence there is an increase in antimicrobial resistance of the pathogen strains, besides other potential side effects for the host. Therefore, it is necessary to explore new alternatives. This review delves into the realm of antimicrobial peptides, exploring their efficacy against H. pylori sourced from diverse origins. Furthermore, it sheds light on food-derived peptides exhibiting remarkable biological activity. These peptides exhibit promising effects on biomarkers associated with H. pylori infection, demonstrating anti-inflammatory and antioxidant properties validated through rigorous testing in both cell and animal models. Regarding the anti-inflammatory activity, the peptide VPY derived from soybean and the peptides derived from animal sources such as meat (β-Ala-His), egg (DEDTQAMPFR, DEDTQAMPF, MLGATSL, MSYSAGF, CR, FL, HC, LL, MK) and milk (IPAV) have reported a reduction of the cytokine IL-8, biomarker directly related to H. infection. For the antioxidant activity, peptides derived from milk (EAMAPK, AVPYPQ) and from Spirulina maxima (LDAVNR, MMLDF) have reduced ROS levels and could have a positive effect on the control of H. infection. Food-derived bioactive peptides with an anti-adhesive effect were also discussed. They derive from vegetable sources (corn, pea and wheat) and are capable of interacting with the host cells, interfering the adherence of H. pylori. Food-derived bioactive peptides have potential to avoid and/or mitigate undesired outcomes of infectious diseases due to the possibility of its application in nutraceuticals and food products, resulting in a preventive approach. Keywords: Helicobacter pylori, antibiotic resistance, bioactive peptides, antimicrobial peptides

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Pederins, mycalamides, onnamides and theopederins: Distinctive polyketide families with intriguing therapeutic potentialities

Tammam,

El-Demerdash

2023

Current Research in Biotechnology

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Drug Discovery from Natural Sources

Cited by 5 publications

References 96 publications

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Pederins, mycalamides, onnamides and theopederins: Distinctive polyketide families with intriguing therapeutic potentialities

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