Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Cavalloro, Valeria; Marrubini, Giorgio; Rossino, Giacomo; Martino, Emanuela; Collina, Simona

doi:10.1039/d3gc03952h

Cited by 1 publication

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References 133 publications

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“…Although conventional extraction remains the main approach for recovering bioactive compounds, the application of eco-friendly extraction methods is continuously increasing, offering healthier and safer food products, cost reduction, and energy safety [24]. However, the bioactivity of a wild olive extract is depended on the extraction method and conditions.…”

Section: Introductionmentioning

confidence: 99%

Valuable Nutrients, Aroma Profile, and Functional Bioactives Extracted by Eco-Friendly Extraction Techniques from Wild Olive Fruits (Olea europaea L. var. sylvestris)

Irakli,

Samara,

Bouloumpasi

et al. 2024

Processes

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Wild olive tree, or oleaster (var. sylvestris), native to the Mediterranean region, is considered a traditional source of healthy food. Wild olive fruit (WOF) exhibits several biological properties associated with its chemical composition. Although Greece has important olive genetic resources, including oleaster populations, limited information is available on the chemical characterization of WOF. Therefore, the present investigation was undertaken to study the nutritional, bioactive (phenolics, tocopherols, and pigments), volatile profile, and antioxidant properties of WOF collected from Greece. Moreover, eco-friendly processes, including ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and accelerated solvent extraction (ASE), were applied to obtain oleuropein-rich extracts from WOF. Evaluation of phenolic composition in WOF extracts was carried out by LC-DAD-ESI-MS, while antioxidant activity was evaluated by applying DPPH, ABTS, and FRAP methods. Our outcomes show that Greek WOF is rich in oleic acid (71.55%), total phenolics (64.89 mg GAE/g dw), tocopherols (107.05 mg/kg dw), and carotenoids (85.90 mg/kg dw). Oleuropein (72.03 mg/g dw) was the main phenolic compound in the WOF extracts. Also, the WOF was characterized by an increased level of volatile compounds, mainly terpenoids (46.73%). UAE was more efficient than MAE and ASE for recovering oleuropein-rich extracts with high antioxidant activity. These results emphasized the high potential of WOF as an alternative bioactive ingredient for use in the food industry.

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Section: Introductionmentioning

confidence: 99%

Valuable Nutrients, Aroma Profile, and Functional Bioactives Extracted by Eco-Friendly Extraction Techniques from Wild Olive Fruits (Olea europaea L. var. sylvestris)

Irakli,

Samara,

Bouloumpasi

et al. 2024

Processes

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Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Abstract: MASE is well suited for use in the nature-aided drug discovery, but the OFAT approach risks limiting the advantages offered by the technique. The way to make it truly green is to couple MASE with DoE, although this coupling is still limited.

Cited by 1 publication

References 133 publications

Valuable Nutrients, Aroma Profile, and Functional Bioactives Extracted by Eco-Friendly Extraction Techniques from Wild Olive Fruits (Olea europaea L. var. sylvestris)

Valuable Nutrients, Aroma Profile, and Functional Bioactives Extracted by Eco-Friendly Extraction Techniques from Wild Olive Fruits (Olea europaea L. var. sylvestris)

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