Drug Delivery via Mucosal Routes

Worakul, Nimit; Robinson, Joseph R.

doi:10.1201/9780203904671.ch40

Cited by 3 publications

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“…During the last two decades, the development of novel mucoadhesive dosage forms has received considerable interest. The progress in this field has recently been summarized in a number of reviews. − Mucoadhesive drug delivery systems can be administered via various routes such as ocular, nasal, gastrointestinal, vaginal, and rectal, which makes them extremely attractive for the development of new dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Design of Mucoadhesive Polymeric Films Based on Blends of Poly(acrylic acid) and (Hydroxypropyl)cellulose

et al. 2006

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Mixing of aqueous solutions of poly(acrylic acid) and (hydroxypropyl)cellulose results in formation of hydrogen-bonded interpolymer complexes, which precipitate and do not allow preparation of homogeneous polymeric films by casting. In the present work the effect of pH on the complexation between poly(acrylic acid) and (hydroxypropyl)cellulose in solutions and miscibility of these polymers in solid state has been studied. The pH-induced complexation-miscibility-immiscibility transitions in the polymer mixtures have been observed. The optimal conditions for preparation of homogeneous polymeric films based on blends of these polymers have been found, and the possibility of radiation cross-linking of these materials has been demonstrated. Although the gamma-radiation treatment of solid polymeric blends was found to be inefficient, successful cross-linking was achieved by addition of N,N'-methylenebis(acrylamide). The mucoadhesive potential of both soluble and cross-linked films toward porcine buccal mucosa is evaluated. Soluble films adhered to mucosal tissues undergo dissolution within 30-110 min depending on the polymer ratio in the blend. Cross-linked films are retained on the mucosal surface for 10-40 min and then detach.

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