Drug delivery to the upper small intestine window using gastroretentive technologies

Streubel, A.; Siepmann, J.; Bodmeier, Roland

doi:10.1016/j.coph.2006.04.007

Cited by 221 publications

(135 citation statements)

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“…Therefore, such a dosage form will be initially of a smaller size to facilitate swallowing, then it increases in size when it gets to the stomach (Streubel et al, 2006). The size of the dosage form required, may be greater than 5 cm in length and a diameter greater than 3 cm (Klausner et al, 2003a).…”

Section: Factors Affecting Gastric Residence Timementioning

confidence: 99%

“…Also, it is a convenient route of administration for easy access to the systemic circulation. However, drug absorption via this route can be unsatisfactory and variable even following promising in vitro release profiles (Davis, 2005, Streubel et al, 2006. This makes it difficult to predict the in vivo performance of a drug delivery system (DDS), even though the in vitro data are reproducible.…”

Section: Introductionmentioning

confidence: 99%

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Gastroretentive microparticles for drug delivery applications

Adebisi

Conway

2011

Journal of Microencapsulation

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Many strategies have been proposed to explore the possibility of exploiting gastroretention for drug delivery. Such systems would be useful for local delivery, for drugs that are poorly soluble at higher pH or primarily absorbed from the proximal small intestine. Generally, the requirements of such strategies are that the vehicle maintains controlled drug release and exhibits prolonged residence time in the stomach. Despite widespread reporting of technologies, many have an inherent drawback of variability in transit times. Microparticulate systems, capable of distributing widely through the GI tract, can potentially minimize this variation. While being retained in the stomach, the drug content is released slowly at a desired rate,

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Section: Factors Affecting Gastric Residence Timementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gastroretentive microparticles for drug delivery applications

Adebisi

Conway

2011

Journal of Microencapsulation

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“…(Singh & Kim, 2000;Streubel et al, 2006). The bulk density of FDDS is lower than that of gastric fluids and thus it remains buoyant on stomach contents for a long time in the drug releasing process.…”

Section: Preparation Of Intragastric Fdds By Plasma Techniquesmentioning

confidence: 99%

Cold Plasma Techniques for Pharmaceutical and Biomedical Engineering

Sasai¹,

Kondo²,

Yamauchi³

et al. 2011

Biomedical Engineering, Trends in Materials Science

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“…This controlled release technology had made it possible to release drugs at a constant release rate for longer periods of time. However, this benefit had not satisfied a variety of important drugs that (i) are locally active in the stomach, (ii) have an absorption window in the stomach or in the upper small intestine, (iii) are unstable in the intestinal or colonic environment, or (iv) exhibit low solubilities at high pH values [1][2][3]. These limits promoted the development of gastroretentive drug delivery systems (GRDDS).…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Gastroretentive Drug Delivery System for Ritonavir Tablets Using Natural Polymers

Chukka

Shaik

2017

Asian J Pharm Clin Res

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Objective: This study involves preparation and evaluation of floating tablets of ritonavir (RN) for improving the drug bioavailability by prolongation of gastric residence time. RN is an antiretroviral agent used in the treatment of HIV and viral diseases have been taken as a model drug in this investigation because of its low biological half-life (3-5 hrs). Moreover, it is primarily absorbed from stomach.Methods: RN floating tablets were prepared by the dry granulation technique, using guar gum and xanthan gum as polymers, sodium bicarbonate as effervescent agent, polyvinylpyrrolidone as binding agent, Dicalcium phosphate as diluents, crospovidone as swelling agent and magnesium stearate as lubricant. The prepared tablets were evaluated for various physicochemical parameters.Results: Drug-excipient interaction studies were conducted by Fourier transform infrared spectroscopy and differential scanning calorimetry. The results suggested that there was no incompatibility between the drug and polymers. The prepared tablets were evaluated for their physical characteristics. All the parameters were within the pharmacopoeial limits. Further, tablets were also studied for their floating properties and in vitro drug release characteristics. The tablets exhibited controlled and prolonged drug release profiles. The developed formulation was found to be stable. Conclusion:The developed floating tablets of RN exhibit prolonged release up to 12 hrs, and thus may improve bioavailability and minimize fluctuations in plasma drug concentrations.

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Drug delivery to the upper small intestine window using gastroretentive technologies

Cited by 221 publications

References 50 publications

Gastroretentive microparticles for drug delivery applications

Gastroretentive microparticles for drug delivery applications

Cold Plasma Techniques for Pharmaceutical and Biomedical Engineering

Development and Characterization of Gastroretentive Drug Delivery System for Ritonavir Tablets Using Natural Polymers

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