Drug Delivery through Targeted Approach with Special References to Phytosomes

Abstract

Novel drug delivery is a great tool to deliver the drug at a specific site of action by the means of specific drug carrier like Solid-lipid Nanoparticles, Nanostructured lipid carriers, lipid vesicles, liposomes, phytosomes and ethosomes. Every carrier used in novel drug delivery system to deliver the drug at targeted site requires some special formulation techniques. These techniques help the drug carrier to deliver the active drug at targeted site, by reducing the side-effect, minimizing the dose, increasing the absorption and increasing the efficacy of the drug. There is a recent upsurge to move "back to nature" for healing body ailments because the report states that conventional treatment cause various side effects to the human body after prolonged used. Various novel drug delivery vesicles/'somes' are being used for the delivery of phytoconstitutents to the targeted site of action. Phytosome is one of the more reliable and best option for the delivery of herbal constituent to the targeted site. The combination of Novel drug delivery with the transdermal route may be a good idea having fast and targeted delivery of drug. Many health challenges like skin diseases, skin burns, migraine, allergies, cardiac problems, diabetes and trauma like bone fracture could be easily managed by the combination of novel drug delivery and the transdermal route in future.

Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook

“…Even in the case of conformationally sensitive ones, the medication candidates supplied by aquasomes show greater biological activity. Aquasome is an effective delivery system transporting biological compounds such as a peptide, proteins, hormones, antigens, and genes to specific places due to its features that protect and preserve delicate biomolecules, maintain structural integrity and expose surface area [ 43 ].…”

“…The development of phytosome nanotechnology may have an impact on medicine delivery by removing obstacles caused by inadequate lipid solubility and increasing the bioavailability of bioactive phytochemicals [ 12 ]. The efficacy of phytosomal carriers allows them to be applied topically to increase the bioavailability of phytoconstituents [ 43 ].…”

Recent Developments in Oral Delivery of Vaccines Using Nanocarriers

“…Aqueous-based phytomedicine–phospholipid complexes generate phytosomes, which are colloidal, small-sized vesicles, such as liposomes, having micellar or hexagonal nanostructures. They are sometimes referred to as pharmacosomes in the pharmaceutical industry [ 107 , 108 ]. Limitations associated with conventional drug delivery systems have been resolved by the discovery of advanced drug delivery vesicles.…”

Phytosomes: A Promising Nanocarrier for Enhanced Delivery of Herbal Compounds in Cancer Therapy

“…Phytosomes can be used as effective carriers for drug delivery because their cores consist of phospholipids and cholesterol, similar to biomembranes 56 . These lipids are readily accepted by the human body without causing antigenic or pyrogenic responses, making them a promising option for cancer therapy.…”