Drug delivery systems based on nanoparticles and related nanostructures

Nikezić, Ana V. Vujačić; Bondžić, Aleksandra M.; Vasić, Vesna

doi:10.1016/j.ejps.2020.105412

Cited by 68 publications

(35 citation statements)

References 208 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They usually consist of metals but they also could be protein and nucleic acid-based NPs or other biodegradable material-based NPs such as lipids (micelles, liposomes, phospholipids) or synthetic polymers (dextran, chitosan), silica, metal, and carbon [7].…”

Section: Nanoparticlesmentioning

confidence: 99%

“…Active 3. Physical targeting The first approach (passive targeting) includes selective delivery by utilizing leaky vasculature and direct administration or implantation at the desired site [7]. The strategy of passive targeting has been successfully used to reach sites of leaky vasculature typical for tumors, sites of inflammation, infection or angiogenesis [8].…”

Section: Mechanisms Of Drug Deliverymentioning

confidence: 99%

“…As targeting ligands a broad variety of molecules including proteins, antibodies, antibody fragments, peptides, aptamers or small molecules has been explored in enhancing drug delivery [8,9]. It has been extensively investigated to overcome the barriers to drug delivery, for example, the blood brain barrier (BBB), cell membrane barrier [1,7].…”

Section: Mechanisms Of Drug Deliverymentioning

confidence: 99%

See 2 more Smart Citations

Lipid Based Drug Delivery System: A Review

Zubair

Sheshe

Bashir

et al. 2021

JALSI

View full text Add to dashboard Cite

Associated with the old/traditional of method of drug delivery are several limitation ranging from first-pass effect, low tolerance, minimal bioavailability, fluctuation of plasma drug concentration which result to less or no desired effect produced. This call for the demand for a more efficient drug administration technique. Lipid systems are biocompatible, inert and biodegradable, stable and deliver at the target with the desired effect. This paper attempt to describe several types of lipid particles used to deliver drug compounds and their applications as therapeutic agent in treating different clinical condition.

show abstract

Section: Nanoparticlesmentioning

confidence: 99%

Section: Mechanisms Of Drug Deliverymentioning

confidence: 99%

Section: Mechanisms Of Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Lipid Based Drug Delivery System: A Review

Zubair

Sheshe

Bashir

et al. 2021

JALSI

View full text Add to dashboard Cite

show abstract

“…Thus, different materials, including silica, carbon nanotubes and polystyrene should be explored as the supporting materials for these solvents to obtain the supported ionic liquids [8]. Additionally, sporopollenin can be obtained via enzymatic isolation techniques by exploiting various enzymes such as pectinase, pronase, cellulysin, amylase, lipase, and hemicellulase [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Plant Pollen Grains: A Move Towards Green Drug and Vaccine Delivery Systems

Iravani

Varma

2021

Nano-Micro Lett.

View full text Add to dashboard Cite

Pollen grains and plant spores have emerged as innovative biomaterials for various applications such as drug/vaccine delivery, catalyst support, and the removal of heavy metals. The natural microcapsules comprising spore shells and pollen grain are designed for protecting the genetic materials of plants from exterior impairments. Two layers make up the shell, the outer layer (exine) that comprised largely of sporopollenin, and the inner layer (intine) that built chiefly of cellulose. These microcapsule shells, namely hollow sporopollenin exine capsules have some salient features such as homogeneity in size, non-toxic nature, resilience to both alkalis and acids, and the potential to withstand at elevated temperatures; they have displayed promising potential for the microencapsulation and the controlled drug delivery/release. The important attribute of mucoadhesion to intestinal tissues can prolong the interaction of sporopollenin with the intestinal mucosa directing to an augmented effectiveness of nutraceutical or drug delivery. Here, current trends and prospects related to the application of plant pollen grains for the delivery of vaccines and drugs and vaccine are discussed. "Image missing"

show abstract

“…Nanoemulsions with a structured interface, achieved with the deposition of multiple layers of emulsifiers and/or polyelectrolytes through electrostatic and hydrophobic interactions [ 18 ], exhibit greatly improved physical stability under extreme conditions of temperature, pH and ionic strength [ 19 ], by increasing the packing density at the interface [ 20 ], enhancing absorption properties in the gastrointestinal tract [ 21 ], controlling or triggering release upon using functionalized polymers [ 22 ], and responding to external stimuli [ 21 , 23 ]. Liposomes are nanosized artificial vesicles, typically made of bilayers of phospholipid and cholesterol, which have found wide use as immunological adjuvants and drug carriers [ 24 , 25 ]. They are characterized by the capability to encapsulate both hydrophilic and hydrophobic molecules, high structural versatility, and capability to augment the biological activity of the encapsulated compounds, but limited delivery in vascularized tissue because of their scarce stability in plasma [ 10 ].…”

mentioning

confidence: 99%

Changing the Vision in Smart Food Design Utilizing the Next Generation of Nanometric Delivery Systems for Bioactive Compounds

Donsı̀

Ferrari

2020

Foods

View full text Add to dashboard Cite

In modern foods, the delivery systems for bioactive compounds play a fundamental role in health promotion, wellbeing, and disease prevention through diet. Nanotechnology has secured a fundamental role in the fabrication of delivery systems with the capability of modulating the in-product and in-body behavior for augmenting bioavailability and activity of bioactive compounds. Structured nanoemulsions and nanoparticles, liposomes, and niosomes can be designed to improve bioactives preservation after ingestion, mucoadhesion, as well as of their release and pathophysiological relevance. In the future, it is expected that the delivery systems will also contribute to augment the efficacy of the bioactive compounds, for example by improving the intestinal absorption and delivery in the bloodstream, as well as promoting the formation of additional bioactive metabolites by regulating the transformations taking place during digestion and the interaction with the intestinal microbiota.

show abstract

Drug delivery systems based on nanoparticles and related nanostructures

Cited by 68 publications

References 208 publications

Lipid Based Drug Delivery System: A Review

Lipid Based Drug Delivery System: A Review

Plant Pollen Grains: A Move Towards Green Drug and Vaccine Delivery Systems

Changing the Vision in Smart Food Design Utilizing the Next Generation of Nanometric Delivery Systems for Bioactive Compounds

Contact Info

Product

Resources

About