Drug Delivery Systems and Controlled Release

Kohrs, Nicholas J.; Liyanage, Thilanga; Venkatesan, Nandakumar; Najarzadeh, Amir; Puleo, David A.

doi:10.1016/b978-0-12-801238-3.11037-2

Cited by 14 publications

(12 citation statements)

References 18 publications

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“…Local drug delivery using polymeric matrices has been widely explored in the last decades as a strategy to limit systemic toxicity [15,16] and particularly applied to chemotherapeutics by locally delivering the drug directly to the target tissue [17]. Moreover, such drug delivery systems (DDS) can be customized to sustain drug release, which enhances therapeutic efficacy [18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Gelatin Methacryloyl Hydrogels Control the Localized Delivery of Albumin-Bound Paclitaxel

et al. 2020

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Hydrogels are excellent candidates for the sustained local delivery of anticancer drugs, as they possess tunable physicochemical characteristics that enable to control drug release kinetics and potentially tackle the problem of systemic side effects in traditional chemotherapeutic delivery. Yet, current systems often involve complicated manufacturing or covalent bonding processes that are not compatible with regulatory or market reality. Here, we developed a novel gelatin methacryloyl (GelMA)-based drug delivery system (GelMA-DDS) for the sustained local delivery of paclitaxel-based Abraxane®, for the prevention of local breast cancer recurrence following mastectomy. GelMA-DDS readily encapsulated Abraxane® with a maximum of 96% encapsulation efficiency. The mechanical properties of the hydrogel system were not affected by drug loading. Tuning of the physical properties, by varying GelMA concentration, allowed tailoring of GelMA-DDS mesh size, where decreasing the GelMA concentration provided overall more sustained cumulative release (significant differences between 5%, 10%, and 15%) with a maximum of 75% over three months of release, identified to be released by diffusion. Additionally, enzymatic degradation, which more readily mimics the in vivo situation, followed a near zero-order rate, with a total release of the cargo at various rates (2–14 h) depending on GelMA concentration. Finally, the results demonstrated that Abraxane® delivery from the hydrogel system led to a dose-dependent reduction of viability, metabolic activity, and live-cell density of triple-negative breast cancer cells in vitro. The GelMA-DDS provides a novel and simple approach for the sustained local administration of anti-cancer drugs for breast cancer recurrence.

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Section: Introductionmentioning

confidence: 99%

Gelatin Methacryloyl Hydrogels Control the Localized Delivery of Albumin-Bound Paclitaxel

et al. 2020

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“…As reported in the literature, possible alternatives to overcome these problems are drug encapsulation and manufacture of controlled release systems . Among the many competitive advantages that can be obtained in these cases, one can cite the increase of drug absorption rates, attainment of more uniform drug concentrations in the body, reduction of the amounts required for drug administration, improvement of patient compliance, and reduction of treatment costs …”

Section: Introductionmentioning

confidence: 99%

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Paiva

Alves

Melo

et al. 2019

Macro Reaction Engineering

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Schistosomiasis is a parasitic disease that affects millions of people, especially low‐income people, and is considered a major public health problem in underdeveloped countries. The drug used most often for the treatment of the disease is praziquantel (PZQ), which has a strong and characteristic bitter taste that makes treatment of children inconvenient. For this reason, the present work investigates the development of smart pH‐sensitive polymer microparticles produced through suspension polymerizations to be used as vehicles for the controlled release of praziquantel in the body. The microparticles are produced through copolymerization of methyl methacrylate and the cationic comonomers diethylaminoethyl methacrylate or dimethylaminoethyl methacrylate. The obtained results indicate that microparticles with sizes in the range of 10–1100 µm can be formed successfully, allowing high PZQ encapsulation efficiencies (>80%). Zeta potential analyses and drug release assays confirm the pH‐sensitive responses of the cationic copolymers, leading to effective release of PZQ (around 80% in pH 1.2) in acidic media that simulate the organic fluids present in the stomach.

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“…There is a wide range of technologies that can be applied to achieve this aim, and they can influence different aspects of the process: drug release rates, drug adsorption in the body, the timing of the adsorption, and so on [4]. At the same time, each of these aspects can be realized in different ways: herein our attention is focused on the drug's delivery and its release, since these are the main steps that can be influenced by the framework in which the drug is loaded.…”

Section: Introductionmentioning

confidence: 99%

“…The drug release can take place because of diffusion gradient, degradation of the support in which the drug is trapped, swelling behavior, or mechanisms based on affinity [4]. In recent years, great consideration has been given to nanoparticles as a drug delivery platform, particularly polymeric nanoparticles [5], which are colloidal particles with dimensions between 1 and 100 nm that are very interesting because of their properties such as biocompatibility, biodegradability, water solubility, and non-toxicity [6].…”

Section: Introductionmentioning

confidence: 99%

Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

Pinelli

Perale

Rossi

2020

Gels

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Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be adopted in order to modify the selectivity of the nanoparticles in the delivery process and obtain a final system with great targeted drug delivery ability. We also highlight the most important fields of application of these kinds of delivery systems and we propose a comparison between the advantages and disadvantages of the described functionalization strategies.

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Drug Delivery Systems and Controlled Release

Cited by 14 publications

References 18 publications

Gelatin Methacryloyl Hydrogels Control the Localized Delivery of Albumin-Bound Paclitaxel

Gelatin Methacryloyl Hydrogels Control the Localized Delivery of Albumin-Bound Paclitaxel

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

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