Drug Delivery Observation of Hydrophobe Ferrofluid and Magnetite Nanoparticals by SPring-8 Synchrotron Radiation

Ju, Dong Ying; Bian, Pei; Kobayashi, Takashi; Nakano, Masahiro; Matsuura, Hiroyuki; Umetani, Keiji; Komdo, T.; Uozumi, Yusuke; Makino, Kenichi; Noda, Naoki; Koide, Kazunori; Akutsu, Masako; Masuyama, Kento

doi:10.1166/jnn.2011.3465

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…The physical characteristics of dendrimers, including water solubility, monodispersity, encapsulation ability and functionalizable peripheral groups, make them to be appropriate candidates for drug carrier. [38][39][40][41][42][43][44][45][46][47][48][49] Applications of the dendrimers for drug carrier are as following. [50][51][52][53][54][55] Firstly, the drug is covalently attached to the periphery of the dendrimer to form dendrimer prodrug; Secondly, drug molecules are conjugated to the outer carboxyl or amino groups via ionic interactions; Last but not least, the dendrimer encapsulates hydrophobic pharmaceutical compounds in the formation of self-assembly dendrimer-drug supramolecular.…”

Section: Drug Carriersmentioning

confidence: 99%

Advances in Applications of Dendritic Compounds

Ma²,

Deng³

et al. 2013

j. nanosci. nanotech.

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Dendritic compounds (so-called dendrimers) with nano-scale represent unique symmetric and spherical structures. They are usually prepared through two fundamental methods based on molecular level which involved the convergent method and divergent method, although the synthetic methods have a tendency towards the diversity and functionalization. The outershell of dendrimers with rich peripheral reactive sites are easily modified by small functional molecules. Moreover, the higher generation dendrimers also possess more exposed functional groups on the surface prior to the previous one and they are much easily customized for much more applications. Consequently, based on previous researches, this review summarized wide applications of dendritic compounds in many fields which were investigated in detail, including gene vector, drug carrier, catalysis, sensor industry, photoelectric material, etc. Dendrimers provide promising tools for the cellular delivery of molecular cargos ranging in size from small molecules and peptides to proteins and DNA. More importantly, it is necessary to explore new synthetic methods and undiscovered applications of new dendrimers.

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Section: Drug Carriersmentioning

confidence: 99%

Advances in Applications of Dendritic Compounds

Ma²,

Deng³

et al. 2013

j. nanosci. nanotech.

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“…Up to now, magnetic fluid has been successfully used in many engineering fields, such as sealing [4], lubrication [5], locomotion system [6,7], sensors [8][9][10], heat transfer enhancement [11] and so on. In recent years, some emerging applications of magnetic fluid in biological and medical field, like drug delivery [12][13][14] and magnetic hyperthermia treatment [15,16], have aroused considerable attention. However, in the biomedical field, traditional oil-based magnetic fluid has many shortcomings due to the poor fluidity properties and the oil-based carrier liquid which cannot be employed in biological environment [17].…”

Section: Introductionmentioning

confidence: 99%

Research on the effect of different surfactants on fluidity of water-based magnetic fluid

Cao

Zhang

et al. 2020

Smart Mater. Struct.

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In order to expand the range of applications of magnetic fluid, water-based magnetic fluid with different surfactants is synthesized and the property of fluidity has been intensively studied. Three kinds of surfactants (sodium dodecyl sulfate, oleic acid and polyethylene glycol) are used to synthesize three different magnetic fluids with the same magnetic nanoparticles and carrier liquid. Their microstructures and thermal stability of magnetic nanoparticles coated with different surfactants are characterized by transmission electron microscopy and thermogravimetric analysis. Results show that water-based magnetic fluid with sodium dodecyl sulfate agglomerates more obviously while magnetic fluid with polyethylene glycol keeps good dispersion. In addition, magnetic measurements reveal that all these magnetic fluids exhibit typical superparamagnetic behavior and the magnetic fluid using polyethylene glycol as surfactant maintains the specific saturation magnetization of ∼60 emu g −1 . What is more, shear stress and viscosity of these three magnetic fluids are measured by the rotational rheometer. The shear stress increases with the increasing shear rate while the viscosity decreases with the increasing shear rate. This indicates that water-based magnetic fluid has the property of pseudoplastic fluid. What is more, the viscosity of the magnetic fluid with polyethylene glycol as surfactant is lower than other two magnetic fluids and is prone to reach a steady state at a low shear rate in a short time.

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“…The ER fluids have similar working principle except for electrically controlled rheological properties instead of the magnetic field [9]. This exclusive property of MRF is utilized in many commercial applications of semi active devices such as dampers, clutches, actuators and other applications such as medical applications, glass polishing and many more [10][11][12][13][14][15][16][17][18][19]. The rheological properties of MRFs depend on the type of suspended particles used and their concentration and the applied magnetic field [20].…”

Section: Introductionmentioning

confidence: 99%

Study on Sedimentation Stability of Mahua and Simarouba Oil Based Magnetorheological Fluids

Vannarth¹,

Babu²,

Jebraj³

2019

Acta mech. Malays.

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Magnetorheological fluids (MRFs) are peculiar of smart fluids whose rheological properties can be efficiently controlled by varying applied magnetic field. Owing to this peculiar property, it can be utilized in industrial applications in semi-active devices such as dampers, actuators, etc. In this work, an effort has been attempted to produce MRFs using natural oils as carrier fluids and tested for potential replacement of conventional carrier fluids such as silicone oil. The MR fluids are prepared using silicone oil and two natural oil namely Mahua oil and Simarouba oil. Carbonyl iron (CI) and Electrolytic iron (EI) are used as suspended particles with lithium grease as an additive. The MRF using two natural based oil are known as Green magneto rheological fluids (GMRF). The characterization of suspended particles and carrier liquids was performed, followed by tests on sedimentation stability of prepared samples. To compare the sedimentation stability, the graphs of sedimentation ratio versus time are plotted for all MR fluids samples. It is found that the sedimentation stability of natural oils based MRFs are relatively better than silicone oil based MRFs for the same concentration of magnetic particles. There is potential of these natural oils based MRFs to replace the conventional MRFs However, other rheological properties like yield strength, flow characteristics etc. needs further investigation.

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Drug Delivery Observation of Hydrophobe Ferrofluid and Magnetite Nanoparticals by SPring-8 Synchrotron Radiation

Cited by 5 publications

References 21 publications

Advances in Applications of Dendritic Compounds

Advances in Applications of Dendritic Compounds

Research on the effect of different surfactants on fluidity of water-based magnetic fluid

Study on Sedimentation Stability of Mahua and Simarouba Oil Based Magnetorheological Fluids

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