Drug Attitude in Adolescents

Abstract

Our observations provide confirmation, also in adolescents, that drug attitude is strongly correlated with treatment compliance and underline the need in clinical assessments to always consider the patient's viewpoint.

Antipsychotic Treatment Failure: A Systematic Review on Risk Factors and Interventions for Treatment Adherence in Psychosis

“…Most studies included an adult population, with the exception of one study with an age range of 14–19 years (Molteni et al, 2014 ). Several studies on the factors associated with medication adherence enrolled participants at early stage of illness (first episode of psychosis, recent onset of psychosis) (Coldham et al, 2002 ; Mutsatsa et al, 2003 ; Kahn et al, 2008 ; Quach et al, 2009 ; Weiden et al, 2012 ; Molteni et al, 2014 ; Winton-Brown et al, 2017 ). Not all studies reported ethnic background.…”

“…Unsurprisingly, an overall positive attitude toward antipsychotic medication is highly associated with adherence (Day et al, 2005 ; Quach et al, 2009 ; Meier et al, 2010 ; Yang et al, 2012 ), a finding that has been replicated in adolescents with psychosis (Molteni et al, 2014 ), and in clinically stable patients with schizophrenia and schizoaffective disorders (Klingberg et al, 2008 ). In addition, a change toward more positive attitudes (Mohamed et al, 2009 ) was correlated with greater medication adherence.…”

“…Additionally, current but not previous misuse of cannabis represents a clear risk factor for non-adherence, pointing out the importance of abstention strategies toward improving adherence behavior (Coldham et al, 2002 ; Janssen et al, 2006 ; Quach et al, 2009 ; Foglia et al, 2017 ; Winton-Brown et al, 2017 ). Unsurprisingly, patients' attitudes and beliefs about medication and illness represent another key modifiable risk factor (Day et al, 2005 ; Quach et al, 2009 ; Meier et al, 2010 ; Yang et al, 2012 ; Molteni et al, 2014 ) across all stages of the disorder. A clear positive impact on adherence may be generated by involving family members (Klingberg et al, 2008 ; Baloush-Kleinman et al, 2011 ; Winton-Brown et al, 2017 ) that support the patient and their treatment.…”

“…Shockingly, half of the included studies relied solely on subjective reports or rating scales of adherence. Several studies also used unstandardized and unvalidated subjective adherence measurement tools (Coldham et al, 2002 ; Bechdolf et al, 2005 ; Borras et al, 2007 ; Kahn et al, 2008 ; Acosta et al, 2009 ; Mohamed et al, 2009 ; Quach et al, 2009 ; Yang et al, 2012 ; Molteni et al, 2014 ; Winton-Brown et al, 2017 ). Valid and reliable therapeutic drug monitoring methods are now increasingly available for the most common antipsychotic drugs (Patteet et al, 2014 ), and it is hard to understand why TDM is not used more widely, both in clinical practice and in studies that have a primary or secondary focus on adherence assessment.…”

Adherence to Antipsychotic Medication in Bipolar Disorder and Schizophrenic Patients

“…60 A study on adolescents, all treated with antipsychotics, assessed their subjective experience with medication with the “Drug Attitude Inventory” and found that a change to more positive medication attitudes was associated with significantly greater medication adherence, decreases in psychopathology, and improvement in functioning. 61 To achieve this change in patient attitude, it is essential to include psychoeducation in the treatment program, to teach patients about their illness, medication and adverse effects, and relapse prevention. 19…”