Adherence to Antipsychotic Medication in Bipolar Disorder and Schizophrenic Patients

Abstract

Antipsychotics are the drugs prescribed to treat psychotic disorders; however, patients often fail to adhere to their treatment, and this has a severe negative effect on prognosis in these kinds of illnesses. Among the wide range of risk factors for treatment nonadherence, this systematic review covers those that are most important from the point of view of clinicians and patients and proposes guidelines for addressing them. Analyzing 38 studies conducted in a total of 51,796 patients, including patients with schizophrenia spectrum disorders and bipolar disorder, we found that younger age, substance abuse, poor insight, cognitive impairments, low level of education, minority ethnicity, poor therapeutic alliance, experience of barriers to care, high intensity of delusional symptoms and suspiciousness, and low socioeconomic status are the main risk factors for medication nonadherence in both types of disorder. In the future, prospective studies should be conducted on the use of personalized patient-tailored treatments, taking into account risk factors that may affect each individual, to assess the ability of such approaches to improve adherence and hence prognosis in these patients.

Erectile dysfunction in patients taking psychotropic drugs and treated with phosphodiesterase-5 inhibitors

“…We did not investigate help-seeking specifically, but most of our patients were motivated for resolving their ED. Furthermore, people with psychosis tend to be suspicious about drug treatment and doctors and show poor adherence (18). Furthermore, we found significantly more improvement in the group receiving benzodiazepines, indicating their ED was due to an underlying anxiety disorder rather than to their medication.…”

Elebitasunaren eragina gaixo psikotikoen azterketa psikiatrikoan: literaturaren berrikusketa

“…Tratamendu antipsikotikoekiko atxikimendua baxua izaten da normalean. Oraintsu egindako errebisio sistematiko batek % 34-81 arteko atxikimendu-tasak jaso zituen, batez bestekoa % 42 ingurukoa zela zehaztuz (24). Etnizitateak atxikimenduan eragina daukala deskribatu izan da (24,25), eta badirudi ez dagoela beti hizkuntza nagusiaren gaitasun-mailarekin lotuta.…”

“…Oraintsu egindako errebisio sistematiko batek % 34-81 arteko atxikimendu-tasak jaso zituen, batez bestekoa % 42 ingurukoa zela zehaztuz (24). Etnizitateak atxikimenduan eragina daukala deskribatu izan da (24,25), eta badirudi ez dagoela beti hizkuntza nagusiaren gaitasun-mailarekin lotuta. Izan ere, Gilmer eta besteek latinoamerikarrekin eta txinatar-amerikarrekin egindako lanean (25) zera hauteman zuten: latinoen artean ingelesa hobeto menperatzen zutenek maila okerragoa zutenek baino atxikidura eskasagoa zeukatela.…”

The impact of a person-centred community pharmacy mental health medication support service on consumer outcomes

“…Alongside this is the ongoing focus to improve our understanding of consumer adherence to these medications (García et al, 2016;Woodward et al, 2016), or the effectiveness of interventions in this area (Al-Jumah & Qureshi, 2012;Chong et al, 2011;Thompson & McCabe, 2012). Mental health consumers have underscored the importance of health professionals assessing the appropriateness of medication before being blamed for non-adherence (Happell et al, 2004).…”