Drug adherence for antihypertensive medications and its determinants among adult hypertensive patients attending in chronic clinics of referral hospitals in Northwest Ethiopia

Mekonnen, Habtamu Sewunet; Gebrie, Mignote Hailu; Eyasu, Kokeb Haile; Gelagay, Abebaw Addis

doi:10.1186/s40360-017-0134-9

Cited by 50 publications

(109 citation statements)

References 33 publications

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“…Moreover, participants who purchased medications by themselves were less likely to adhere to their medications than participants who get their mediations freely. This is similar with a study done in northwest Ethiopia which showed higher odds of adherence to antihypertensive medications in respondents who had got the medication/s free of charge or with low cost as compared to those who had got the medication/s with high cost [ 34 ]. This might be attributable to the economic constraint of the former participants.…”

Section: Discussionsupporting

confidence: 90%

Antihypertensive medication adherence and associated factors among adult hypertensive patients at Jimma University Specialized Hospital, southwest Ethiopia

2018

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BackgroundAdherence to antihypertensive medications is a key component to control blood pressure levels. Poor adherence to these medications leads to the development of hypertensive complications and increase risk of cardiovascular events which in turn reduces the ultimate clinical outcome. The purpose of this study was to assess antihypertensive medication adherence and associated factors among adult hypertensive patients. A hospital-based cross-sectional study among adult hypertensive patients was conducted at hypertensive follow-up clinic of Jimma University Specialized Hospital from March 4, 2015 to April 3, 2015. A simple random sampling technique was used to select the study participants from the study population. The study patients were interviewed and their medical charts were reviewed using a pretested structured questionnaire. Adherence was assessed using Morisky Medication Adherence Scale-8 (MMAS-8) and MMAS-8 score less than 6 was considered as non-adherent and MMAS-8 score was ≥ 6 was declared as adherence. Factors associated with adherence were identified using binary and multivariate logistic regression analysis. Crude odds ratio, adjusted odds ratio (AOR) and 95% confidence interval of the odds ratio were calculated using SPSS version 21. Variables with p-value less than 0.05 were assumed as statistically significant factors.ResultsAmong 280 hypertensive patients, 61.8% of the study participants were found to be adherent. More than half (53.2%) of the participants were males and the mean age of the participants was 55.0 ± 12.7 years. Co-morbidity (AOR = 0.083, 95% CI = 0.033–0.207, p < 0.001), alcohol intake (AOR = 0.011, 95% CI = 0.002–0.079, p < 0.001), getting medications freely (AOR = 0.020, 95% CI = 0.003–0.117, p < 0.001), and combination of antihypertensive medications (AOR = 0.32, 95% CI = 0.144–0.712, p < 0.005) were inversely associated with antihypertensive medication adherence.ConclusionThe adherence level to the prescribed antihypertensive medications was found to be sub-optimal according to the MMAS-8, and influenced by co morbidity, alcohol intake, self-purchasing of the medications and combination of antihypertensive medications.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3139-6) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 90%

Antihypertensive medication adherence and associated factors among adult hypertensive patients at Jimma University Specialized Hospital, southwest Ethiopia

2018

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“…Self-reported adherence in the walkway model was better than in health facility and weekend clinics. The selfreported adherence in this study is much higher than shown in other studies in Africa: 53.8% in Korogocho slum, Nairobi [24], 57.2% in Nigeria [25] and 67.2% in North-west Ethiopia [26]; it is also higher than in Pakistan (76.6%) [27] and Sunderland (79%) [28]. The difference in results may be due to sociodemographic characteristics, self-reported adherence or models of care.…”

Section: Discussioncontrasting

confidence: 85%

Compliance with follow‐up and adherence to medication in hypertensive patients in an urban informal settlement in Kenya: comparison of three models of care

Kuria

Reid

Owiti

et al. 2018

Tropical Med Int Health

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Abstractobjective To determine and compare, among three models of care, compliance with scheduled clinic appointments and adherence to antihypertensive medication of patients in an informal settlement of Kibera, Kenya.methods Routinely collected patient data were used from three health facilities, six walkway clinics and one weekend/church clinic. Patients were eligible if they had received hypertension care for more than 6 months. Compliance with clinic appointments and self-reported adherence to medication were determined from clinic records and compared using the chi-square test. Univariate and multivariate logistic regression models estimated the odds of overall adherence to medication.results A total of 785 patients received hypertension treatment eligible for analysis, of whom twothirds were women. Between them, there were 5879 clinic visits with an overall compliance with appointments of 63%. Compliance was high in the health facilities and walkway clinics, but men were more likely to attend the weekend/church clinics. Self-reported adherence to medication by those complying with scheduled clinic visits was 94%. Patients in the walkway clinics were two times more likely to adhere to antihypertensive medication than patients at the health facility (OR 1.97, 95% CI 1.25-3.10).conclusion Walkway clinics outperformed health facilities and weekend clinics. The use of multiple sites for the management of hypertensive patients led to good compliance with scheduled clinic visits and very good self-reported adherence to medication in a low-resource setting.keywords hypertension, models of care, walkway clinics, weekend clinics, medical management, operational research

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“…In contrast to our findings, there was no significant association between number of medications taken and adherence level in other national studies [9,21]. In a third international study conducted in northwest Ethiopia, Mekonnen et al [26] showed that participants who had no comorbidity were four times more likely to adhere to antihypertensive medications than their counterparts.…”

Section: Discussioncontrasting

confidence: 99%

Prevalence of Nonadherence to Antihypertensive Medications among Adults Attending Primary Healthcare Clinics in Al-Hasa Region: A Cross-Sectional Study

Alkhamis¹,

Alsalman²,

Khamis³

et al. 2019

DSAHMJ

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To assess the prevalence of nonadherence to antihypertensive medications among adults attending Primary Healthcare Clinics (PHCs) in Al-Hasa Region. This cross-sectional study included participants from a variety of clinics in the region and each of them had been interviewed to complete the questionnaire. The participants were selected by random sampling from eight different PHCs. Data were collected by a structured questionnaire that was adopted from two different scales to determine the association between adherence and socioeconomic and health status characteristics. We included 372 participants with a mean (±standard deviation) age of 53 ± 12.4 years and most of them were male (62%, n = 231). The overall mean adherence based on our adapted scale was 5.3 ± 2.3. Among participants taking more than six medications, the percentage of nonadherent participants was significantly higher than the percentage of adherent participants (85% vs. 15%, p = 0.016). Participants with single comorbidity were more likely to be adherent than patients with multiple comorbidities (odds ratio = 1.52, p = 0.049). In conclusion, we found a high prevalence of nonadherence to antihypertensive medications in the Al-Hasa community and the main association factor was found to be the presence of comorbidity. Such high rate sends alarming messages for the need of potential interventions to improve adherence outcome.

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Drug adherence for antihypertensive medications and its determinants among adult hypertensive patients attending in chronic clinics of referral hospitals in Northwest Ethiopia

Cited by 50 publications

References 33 publications

Antihypertensive medication adherence and associated factors among adult hypertensive patients at Jimma University Specialized Hospital, southwest Ethiopia

Antihypertensive medication adherence and associated factors among adult hypertensive patients at Jimma University Specialized Hospital, southwest Ethiopia

Compliance with follow‐up and adherence to medication in hypertensive patients in an urban informal settlement in Kenya: comparison of three models of care

Prevalence of Nonadherence to Antihypertensive Medications among Adults Attending Primary Healthcare Clinics in Al-Hasa Region: A Cross-Sectional Study

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