Prevalence of Nonadherence to Antihypertensive Medications among Adults Attending Primary Healthcare Clinics in Al-Hasa Region: A Cross-Sectional Study

Alkhamis, Abdulrahim M.; Alsalman, Abdulkhaliq J.; Khamis, M.; Alkhamis, Abdullah; Alotaibi, Nawaf M.

doi:10.2991/dsahmj.k.190516.001

Cited by 4 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…51 On the other hand, other studies in KSA found that patients with hypertension and diabetes have low adherence. [52][53][54] This disparity could be because of the high prevalence of these conditions hence people are familiar with non-adherence consequences and the current study small sample size.…”

Section: Discussionmentioning

confidence: 87%

Evaluation of medication adherence among patients with chronic diseases in Saudi Arabia

et al. 2021

View full text Add to dashboard Cite

Poor medication adherence is a global problem that compromises the benefit of a given treatment. 1 It also increases the rate of mortality, morbidity and healthcare costs. 2 In the United States, direct medical cost of chronic diseases reached a trillion dollar, while nonadherence costs over $170 billion annually. 2,3 Furthermore, in transplant recipients, the non-adherence to immunosuppressants results in 1319 cases of renal transplant failure annually. 4 The achievement of the total benefit from medication is determined by patient adherence to their treatment regimens. 5 Adherence is defined as the "extent to which a patient acts in accordance with the prescribed interval and dose and dosing regimen". 6 Half of the prescribed medications for chronic diseases are not taken as prescribed by their healthcare providers. 2 Hypertension is one of the chronic medical conditions that affects a great percentage of people all over the globe. In 2000, the estimated number of adults with hypertension was 972 million and

show abstract

Section: Discussionmentioning

confidence: 87%

Evaluation of medication adherence among patients with chronic diseases in Saudi Arabia

et al. 2021

View full text Add to dashboard Cite

show abstract

“…A total of 2,532,582 Asian subjects were included in 66 selected studies. Eight studies each from India [21,52,77,45,65,34,66,48] and Saudi Arabia [24,41,59,31,[68][69][70][71], six each from Bangladesh [53][54][55][56][57]76] and China [16,17,38,39,63,78],…”

Section: Characteristics Of Studies Includedmentioning

confidence: 99%

Prevalence of non-adherence to antihypertensive medication in Asia: a systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

Background: Hypertension and its associated complications are one of the leading causes of morbidity and mortality in Asia. Racial disparities in terms of treatment outcomes among hypertension patients have been reported in literature with Asian patients resulting in poorer treatment outcomes. Non-adherence to antihypertensive therapy is frequently associated with poor treatment outcomes. Aim of the Review:The aim of this review was to estimate the prevalence of non-adherence to antihypertensive medications among patients with hypertension residing in Asia.Method: PubMed, Google Scholar, MEDLINE, Embase, Scopus, CINHAL and Cochrane library were searched for studies published between 2000 and 2019 involving hypertensive patients. Studies investigating the prevalence of medication non-adherence in Asian countries, rated either good or fair on National Institute of Health quality assessment tool and published in English language were included in our review. Data were extracted by one author and checked by another using a structured and pilot-tested data extraction sheet. A random-effects meta-analysis was performed using STATA version 14.3®. Results:Sixty-Seven studies from 22 Asian countries including 2,532,582 hypertensive patients were included. Mean (±SD) age of participants was 58(±6) years. Overall, the estimated prevalence of non-adherence to antihypertensive medication in Asia was 48% (95% CI: 41-54, P=0.001). The rate of non-adherence was higher among females 49% (95% CI: 41-56, P=0.001) compared to males 47% (95% CI: 40-53, P=0.001). As per the region, the highest prevalence of non-adherence was found in South Asia 48% (95% 44-51, P=0.877) followed by East Asia 45% (31-59, P=0.001) and the Middle East 41 (95% 30-52, P=0.001). Similarly, higher rate of nonadherence was observed in low and lower middle-income countries i.e. 50% (95% CI: 47-54, P=0.220) as compare to upper-middle and high-income countries i.e. 37% (95% CI: 25-49, P=0.001) and 44% (29-59, P=0.001) respectively. Conclusion:The prevalence of non-adherence to antihypertensive medication is high in Asia. This may partly explain poor treatment outcomes and incidence of higher mortality rate in Asia frequently reported in the literature. There is a need to implement appropriate policies and clinical practices to improve medication adherence.

show abstract

Sex differences in the adherence of antihypertensive drugs: a systematic review with meta-analyses

et al. 2020

View full text Add to dashboard Cite

ObjectivesPoor worldwide rate of blood pressure control is largely due to poor adherence to antihypertensive (AHT) drug treatment. The question of whether sex affects adherence has long been debated but conflicting findings have been reported on this issue. Our objective was to evaluate sex differences in the adherence to AHT therapy.Research design and methodsStudies were identified through a systematic search of PubMed, CINAHL, PsycINFO, Web of Science and Google Scholar (through January 2020) and manual handsearching of relevant articles. Observational studies reporting adherence to AHT drugs measured by self-report or pharmacy refill prescription-based methods among men and women were included. Summarised estimates of ORs with 95% CIs were calculated using random-effects model and meta-regression models.ResultsFrom 12 849 potentially relevant publications, 82 studies (15 517 457 men and 18 537 599 women) were included. No significant between-sex differences in adherence to AHT were observed, whether all study-specific estimates were summarised (ORs 1.04, 95% CI 1.00 to 1.09, p=0.07), nor estimates were pooled according to the method for measuring adherence. Among patients aged 65 years or older, lower self-reported adherence was observed in women (ORs 0.84, 95% CI 0.72 to 0.97, p=0.02), while the main result remained unchanged according to other subgroup analyses.ConclusionsDefinitive evidence of sex differences in adherence to AHT therapy cannot be drawn. Our little knowledge about factors affecting adherence, in particular of sex effect among elderly, urgently requires high-quality studies investigating these issues.

show abstract

Prevalence of Nonadherence to Antihypertensive Medications among Adults Attending Primary Healthcare Clinics in Al-Hasa Region: A Cross-Sectional Study

Cited by 4 publications

References 27 publications

Evaluation of medication adherence among patients with chronic diseases in Saudi Arabia

Evaluation of medication adherence among patients with chronic diseases in Saudi Arabia

Prevalence of non-adherence to antihypertensive medication in Asia: a systematic review and meta-analysis

Sex differences in the adherence of antihypertensive drugs: a systematic review with meta-analyses

Contact Info

Product

Resources

About