Drug addiction is associated with leukocyte telomere length

Yang, Zhaoyang; Ye, Junyi; Li, Candong; Zhou, Daizhan; Shen, Qing; Wu, Ji; Cao, Lan; Wang, Ting; Cui, Daxiang; He, Shunping; Qi, Guoyang; He, Lin; Liu, Yun

doi:10.1038/srep01542

Cited by 46 publications

(42 citation statements)

References 32 publications

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“…Shortened telomere length is associated to increased cellular ageing as well as a range of non-communicable age-related diseases, including hypertension, cardiovascular disease, stroke, diabetes and dementia. In fact, drug abusers on METH, heroin or diazepam have shorter telomere length and accelerates cellular senescence [122,124].…”

Section: Meth-induced Inflammation and Link To Ageingmentioning

confidence: 99%

Methamphetamine and its immune-modulating effects

et al. 2019

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Methamphetamine (METH, or ice) use is a global burden, which continues to pervade and plague contemporary society with estimates of up to 35 million users worldwide. METH is a psychotropic compound which acts on the central nervous system, and, in chronic doses, can induce psychotic behavior from its highly addictive nature. METH harbours the capacity to cause modulation of immune cells, enabling the drug to have lasting, long-term effects which may manifest into neuropsychiatric disorders, as well as leading to increased susceptibility to communicable diseases, such as HIV. In addition, changes to the cytokine balance have been associated with blood brain barrier compromise, resulting to alterations to brain plasticity, creating lasting neurotoxicity. Furthermore, immune-related signaling pathways are key to further evaluating how METH impacts the host immunity through these neurological and peripheral modifications. Layering this knowledge with current data on inflammatory responses can help facilitate a better understanding of how the host adaptive and innate immunity responds to METH, how this can activate premature-ageing processes and how METH exacerbates disturbances leading to non-communicable age-related diseases, including cardiovascular disease, stroke, depression and dementia.

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Section: Meth-induced Inflammation and Link To Ageingmentioning

confidence: 99%

Methamphetamine and its immune-modulating effects

et al. 2019

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“…The combination of ethanol and methylenedioxymethamphetamine increases hyperthermic and hepatotoxic effects [31]. Also, drug use (especially of opioids) reduced LTLs, as associated with relapse and route of administration (sniffing related to longer LTLs compared to other methods) [32]. In addition, stem cells (pluripotential progenitor cells from which a whole class of cells differentiate) and their health are a special focus of aging medicine and associated deficits [33].…”

Section: Pathophysiological Processesmentioning

confidence: 99%

Is biological aging accelerated in drug addiction?

Bachi

Sierra

Volkow

et al. 2017

Current Opinion in Behavioral Sciences

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Drug-addiction may trigger early onset of age-related disease, due to drug-induced multi-system toxicity and perilous lifestyle, which remains mostly undetected and untreated. We present the literature on pathophysiological processes that may hasten aging and its relevance to addiction, including: oxidative stress and cellular aging, inflammation in periphery and brain, decline in brain volume and function, and early onset of cardiac, cerebrovascular, kidney, and liver disease. Timely detection of accelerated aging in addiction is crucial for the prevention of premature morbidity and mortality.

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“…Reduced telomere length has also been documented in MDD (10, 40–44), although some studies have been negative (45, 46). A few investigations also found reduced leukocyte telomere length in anxiety disorders (45, 47), post-traumatic stress disorder (PTSD) (48–51), bipolar II disorder (52), schizophrenia (53), and substance use disorders (54, 55). Chronicity of MDD is linked to leukocyte telomere shortening (43, 47, 56), suggesting that loss of telomere length may be a consequence of other aspects of the disease process.…”

Section: Introductionmentioning

confidence: 99%

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Tyrka

Parade

Price

et al. 2016

Biological Psychiatry

228

177

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Background Telomere shortening and alterations of mitochondrial biogenesis are involved in cellular aging. Childhood adversity is associated with telomere shortening, and several investigations have shown short telomeres in psychiatric disorders. Recent studies have examined whether mitochondria might be involved in neuropsychiatric conditions; findings are limited and no prior work has examined this in relation to stress exposure. Methods Two-hundred and ninety healthy adults provided information on childhood parental loss and maltreatment and completed diagnostic interviews. Participants were categorized into four groups based upon the presence or absence of childhood adversity and the presence or absence of lifetime psychopathology (depressive, anxiety, and substance use disorders). Telomere length and mtDNA copy number were measured from leukocyte DNA by qPCR. Results Childhood adversity and lifetime psychopathology were each associated with shorter telomeres (p < .01) and higher mtDNA copy numbers (p < .001). Significantly higher mtDNA copy numbers and shorter telomeres were seen in individuals with major depression, depressive disorders, and anxiety disorders, as well as those with parental loss and childhood maltreatment. A history of substance disorders was also associated with significantly higher mtDNA copy numbers. Conclusion This study provides the first evidence of an alteration of mitochondrial biogenesis with early life stress and with anxiety and substance use disorders. We replicate prior work on telomere length and psychopathology, and show that this effect is not secondary to medication use or comorbid medical illness. Finally, we show that early life stress and psychopathology are each associated with these markers of cellular aging.

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Drug addiction is associated with leukocyte telomere length

Cited by 46 publications

References 32 publications

Methamphetamine and its immune-modulating effects

Methamphetamine and its immune-modulating effects

Is biological aging accelerated in drug addiction?

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

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