Drosophila re-zero their path integrator at the center of a fictive food patch

Behbahani, Amir H.; Palmer, Emily H.; Corfas, Román A.; Dickinson, Michael H.

doi:10.1016/j.cub.2021.08.006

Cited by 21 publications

(38 citation statements)

References 48 publications

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“…A chemosensory stimulus, carbon dioxide, has been shown to elicit a persistent state of blood feeding in female mosquitoes (Sorrells et al, 2022). Persistent responses to brief sugar exposure have been also been described, in which flies show local search behavior in an attempt to locate the previous sugar stimulus (Corfas et al, 2019; Behbahani et al, 2021). These studies show that flies can store a memory of the sugar stimulus over short timescales, but they differ from our study in that they describe persistent behavioral changes, whereas we characterize the ability of sugar to modulate future stimulus responses without eliciting overt behavioral changes in the absence of a stimulus.…”

Section: Discussionmentioning

confidence: 99%

Taste cues elicit prolonged modulation of feeding behavior in Drosophila

Deere

Devineni

2022

Preprint

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SUMMARYTaste cues regulate immediate feeding behavior, but their ability to modulate future behavior has been less well-studied. Pairing one taste with another can modulate subsequent feeding responses through associative learning, but this requires simultaneous exposure to both stimuli. We investigated whether exposure to one taste modulates future responses to other tastes even when they do not overlap in time. Using Drosophila, we found that brief exposure to sugar enhanced future feeding responses, whereas bitter exposure suppressed them. This modulation relies on neural pathways distinct from those that acutely regulate feeding or mediate learning-dependent changes. Sensory neuron activity was required not only during initial taste exposure but also afterward, suggesting that ongoing sensory activity may maintain experience-dependent changes in downstream circuits. Thus, the brain stores a memory of each taste stimulus after it disappears, enabling animals to integrate information as they sequentially sample different taste cues that signal local food quality.

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Section: Discussionmentioning

confidence: 99%

Taste cues elicit prolonged modulation of feeding behavior in Drosophila

Deere

Devineni

2022

Preprint

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“…The heading direction can also be influenced by the polarization of light ( Weir and Dickinson, 2012 ; Hardcastle et al, 2021 ) or the angle of the sun ( Giraldo et al, 2018 ). Furthermore, flies perform local search behavior after encountering a food site ( Kim and Dickinson, 2017 ; Behbahani et al, 2021 ). This behavior appears to involve path integration through the computation of the internal sense of the position and the orientation of the animal ( Kim and Dickinson, 2017 ).…”

Section: Vision-based Spatial Navigationmentioning

confidence: 99%

From Photons to Behaviors: Neural Implementations of Visual Behaviors in Drosophila

Ryu

Kim

2022

Front. Neurosci.

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Neural implementations of visual behaviors in Drosophila have been dissected intensively in the past couple of decades. The availability of premiere genetic toolkits, behavioral assays in tethered or freely moving conditions, and advances in connectomics have permitted the understanding of the physiological and anatomical details of the nervous system underlying complex visual behaviors. In this review, we describe recent advances on how various features of a visual scene are detected by the Drosophila visual system and how the neural circuits process these signals and elicit an appropriate behavioral response. Special emphasis was laid on the neural circuits that detect visual features such as brightness, color, local motion, optic flow, and translating or approaching visual objects, which would be important for behaviors such as phototaxis, optomotor response, attraction (or aversion) to moving objects, navigation, and visual learning. This review offers an integrative framework for how the fly brain detects visual features and orchestrates an appropriate behavioral response.

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“…A model of pheromone-mediated behavior was inspired by, and some of the parameters were reproduced from Behbahani et al, 2021. The model consists of a circular linear channel with reward zones and a fly agent that can perform discrete steps (time step 0.5s) in the channel in two directions and release a pheromone drop at any step. The agent is initiated in global search mode, where it continuously walks forward in one direction.…”

Section: Pheromone Model Of Local Search In a Circular Channelmentioning

confidence: 99%

“…Previous studies which used fly accumulation as evidence for path integration generally have not controlled for the potential effect of fly-emitted pheromones (Corfas et al, 2019;Kim and Dickinson, 2017;Stern et al, 2019), and therefore we argue that they cannot be used as strong evidence that flies indeed are capable of idiothetic path integration. One line of evidence used to argue flies perform path integration comes from recent experiments in which flies were given an optogenetic reward, again by activation of sugarsensing neurons, in a specific location along a circular channel (Behbahani et al, 2021). In that work, repeated visits to the rewarded location, especially after multiple cycles of walking around the circular channel, were interpreted as evidence of path integration.…”

Section: Visitation To Particular Spatial Locations Can Be Mediated B...mentioning

confidence: 99%

“…Left: arena prior to fly introduction; middle: arena with flies; right: arena after emitter flies removed. The pointers indicate the fresh drops (solid) and the dried out drops (transparent).One line of evidence used to argue flies perform path integration comes from recent experiments in which flies were given an optogenetic reward, again by activation of sugarsensing neurons, in a specific location along a circular channel(Behbahani et al, 2021). In that work, repeated visits to the rewarded location, especially after multiple cycles of walking…”

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Displacement experiments provide evidence for path integration in Drosophila

Титова

Kau

Tibor

et al. 2022

Preprint

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Like many other animals, insects are capable of returning to previously visited locations using path integration. Recently, Drosophila has been added to the list of insects thought capable of this navigational memory. Existing experimental evidence, however, has a potential confound. Here we show that pheromones deposited at the site of reward might enable flies to find previously rewarding locations even without memory. Thus, we designed an experiment to determine if flies can use path integration memory despite potential pheromonal cues by displacing the flies shortly after an optogenetic reward. We found that rewarded flies returned to the location predicted by a memory-based model. Several analyses are consistent with path integration as the mechanism by which flies returned to the reward. We conclude that while pheromones may often be important in fly navigation and must be carefully controlled in future experiments, Drosophila may indeed be capable of performing path integration.

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Drosophila re-zero their path integrator at the center of a fictive food patch

Cited by 21 publications

References 48 publications

Taste cues elicit prolonged modulation of feeding behavior in Drosophila

Taste cues elicit prolonged modulation of feeding behavior in Drosophila

From Photons to Behaviors: Neural Implementations of Visual Behaviors in Drosophila

Displacement experiments provide evidence for path integration in Drosophila

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