Droplet-based microfluidics in biomedical applications

Amirifar, Leyla; Besanjideh, Mohsen; Nasiri, Rohollah; Shamloo, Amir; Nasrollahi, Fatemeh; Barros, Natan Roberto de; Davoodi, Elham; Erdem, Ahmet; Mahmoodi, Mahboobeh; Hosseini, Vahid; Montazerian, Hossein; Jahangiry, Jamileh; Darabi, Mohammad Ali; Haghniaz, Reihaneh; Dokmeci, Mehmet R.; Annabi, Nasim; Ahadian, Samad; Khademhosseini, Ali

doi:10.1088/1758-5090/ac39a9

Cited by 71 publications

(52 citation statements)

References 259 publications

(352 reference statements)

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“…The generation process, as well as the resulting droplet frequency, size and interval, are governed by the continuity equation and the Navier-Stokes equation with the volumetric force, including inertial, viscous, interfacial, gravitational and externally applied magnetic force [77]. For a physical understanding, the significance of the forces is usually analyzed by the nondimensionalized number [78]. In Table 1, the most commonly adopted dimensionless number is illustrated by Reynolds, Capillary, Weber, Bond and Magnetic Bond numbers, specifically for magnetic droplet generation.…”

Section: Droplet Generationmentioning

confidence: 99%

“…With different flow rate ratios, the droplet generation process is typically defined as slug flow, dripping flow and jetting flow with or without a magnetic field. The flow pattern and ferrofluid droplet generation can be illustrated in terms of the capillary number of the continuous phase and the Weber number of ferrofluids [78]. The low capillary number makes a slug flow when the continuous phase flow rate is relatively small.…”

Section: Droplet Generationmentioning

confidence: 99%

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Droplet Manipulation under a Magnetic Field: A Review

Zhu

Wang

et al. 2022

Biosensors

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The magnetic manipulation of droplets is one of the emerging magnetofluidic technologies that integrate multiple disciplines, such as electromagnetics, fluid mechanics and so on. The directly driven droplets are mainly composed of ferrofluid or liquid metal. This kind of magnetically induced droplet manipulation provides a remote, wireless and programmable approach beneficial for research and engineering applications, such as drug synthesis, biochemistry, sample preparation in life sciences, biomedicine, tissue engineering, etc. Based on the significant growth in the study of magneto droplet handling achieved over the past decades, further and more profound explorations in this field gained impetus, raising concentrations on the construction of a comprehensive working mechanism and the commercialization of this technology. Current challenges faced are not limited to the design and fabrication of the magnetic field, the material, the acquisition of precise and stable droplet performance, other constraints in processing speed and so on. The rotational devices or systems could give rise to additional issues on bulky appearance, high cost, low reliability, etc. Various magnetically introduced droplet behaviors, such as deformation, displacement, rotation, levitation, splitting and fusion, are mainly introduced in this work, involving the basic theory, functions and working principles.

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Section: Droplet Generationmentioning

confidence: 99%

Section: Droplet Generationmentioning

confidence: 99%

Droplet Manipulation under a Magnetic Field: A Review

Zhu

Wang

et al. 2022

Biosensors

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“…It is a brand-new multidisciplinary field that combines biology, biomedical engineering, microelectronics, fluid physics, chemistry, and novel materials [ 72 ]. Microfluidic devices [ 73 ], also known as chip laboratories and microtonal analysis systems [ 74 ], are typically referred to as microfluidic chips due to their downsizing and integration [ 75 , 76 ].…”

Section: Preparation Of Janus Particlesmentioning

confidence: 99%

Application of Janus Particles in Point-of-Care Testing

et al. 2022

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Janus particles (JPs), named after the two-faced Roman god, are asymmetric particles with different chemical properties or polarities. JPs have been widely used in the biomedical field in recent years, including as drug carriers for targeted controlled drug release and as biosensors for biological imaging and biomarker detection, which is crucial in the early detection and treatment of diseases. In this review, we highlight the most recent advancements made with regard to Janus particles in point-of-care testing (POCT). Firstly, we introduce several commonly used methods for preparing Janus particles. Secondly, we present biomarker detection using JPs based on various detection methods to achieve the goal of POCT. Finally, we discuss the challenges and opportunities for developing Janus particles in POCT. This review will facilitate the development of POCT biosensing devices based on the unique properties of Janus particles.

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“…Previously, droplet microfluidics for single-cell manipulation and analysis has been reviewed concerning certain aspects of its progress, including single-cell encapsulation, 31 single-cell omics, [32][33][34][35] and single-cell microgels for diagnostics and therapeutics. 36 Besides, several review papers on microfluidic technology for single-cell analysis 37 and droplet microfluidics for biomedical applications 38,39 have emerged too. However, there are few reviews on single-cell droplet microfluidics for biomedical applications with emphasis on recent advancements.…”

Section: Introductionmentioning

confidence: 99%