Application of Janus Particles in Point-of-Care Testing

Abstract

Janus particles (JPs), named after the two-faced Roman god, are asymmetric particles with different chemical properties or polarities. JPs have been widely used in the biomedical field in recent years, including as drug carriers for targeted controlled drug release and as biosensors for biological imaging and biomarker detection, which is crucial in the early detection and treatment of diseases. In this review, we highlight the most recent advancements made with regard to Janus particles in point-of-care testing (POCT). Firstly, we introduce several commonly used methods for preparing Janus particles. Secondly, we present biomarker detection using JPs based on various detection methods to achieve the goal of POCT. Finally, we discuss the challenges and opportunities for developing Janus particles in POCT. This review will facilitate the development of POCT biosensing devices based on the unique properties of Janus particles.

Fusion Features of Monocomponent Parts in Janus-Like Nanoscale Clusters Under Impacts of Low− and Ultra−Low−Energy Ar13 and Ar Projectiles

“…In this regard, Janus-like binary clusters [22][23][24][25][26][27][28][29][30][31][32][33], namely nanoparticles consisting of two spatially separated types of atoms having an interface, as a variety of multicomponent clusters, demonstrate essential features of mass transfer regularities and structural changes under external bombardment by energetic multi-and mono-atomic projectiles [34]. The strong in uence of the multi-atomic nature of the bombarding particle on the intensity of nonlinear collisional processes in a nanocluster at relatively low impact energies of several hundred electron-volts was previously shown using the molecular dynamics (MD) simulation of mono-component surface clusters Cu n (n = 13-195 atoms) under bombardment by Cu 2 dimers [35].…”

Spark Discharge Synthesis and Characterization of Ge/Sn Janus Nanoparticles

“…Moreover, the Ge 0.95 Sn 0.05 nanocrystals of a 10 nm diameter exhibited a 25% higher capacity than Ge nanoparticles in anode materials [ 30 ]. A solution-based approach [ 31 ] proposes the synthesis of Ge/Sn alloy nanoparticles with a diameter of 3–25 nm and atomic tin content from 5 to 40% [ 32 , 33 ]. It was demonstrated that pulsed laser deposition and gas-phase laser photolysis allowed for producing Ge/Sn micro- and nanoparticles.…”

“…Promising applications of Janus nanoparticles have been suggested for biosensing, photocatalysis, drug carriers, and photonics [ 33 , 34 , 35 ] due to the combination of different physical and chemical properties in one nanoparticle. Several approaches have been engineered for the preparation of hard Janus biphasic nanoparticles composed of two different inorganic (hard) materials [ 36 ], including epitaxial deposition, a flame synthesis technique, phase separation techniques, and masking methods [ 37 , 38 ].…”