Droghe contenenti lipidi

Capasso, F.

doi:10.1007/978-88-470-1652-1_12

Cited by 1 publication

(1 citation statement)

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“…The approach for the treatment and therapy of BPH is mainly based on the use of inhibitors of 5α-reductase enzyme, in particular natural inhibitors, such as the active compounds present in the alcoholic extracts deriving from species Serenoa repens, a typical palm common in the Subtropical sandy soils and in the southern coasts of the United States. Although the sure mechanism of action of S. repens is not yet fully understood, numerous mechanisms have been proposed (3) and the presence of specific fatty acids (saturated and unsaturated fatty acids) and phytosterols in its alcoholic extracts confers upon S. repens an anti-inflammatory and above all antiproliferative action on prostatic tissue (4). Both a systematic Cochrane review of the literature (5) and a meta-analysis (6) assessed the safety profile and the clinical efficacy of S. repens in the treatment of symptoms in patients with BPH.…”

Section: Original Papermentioning

confidence: 99%

Serenoa repens extracts: In vitro study of the 5α-reductase activity in a co-culture model for Benign Prostatic Hyperplasia

Buonocore¹,

Verri²,

Cattaneo³

et al. 2018

Arch Ital Urol Androl

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Objectives. Benign Prostatic Hyperplasia (BPH) is a form of benign tumor that occurs in humans mainly with ageing. It affects more than 50% of over 50 years old males and it is characterized by an increased synthesis of dihydrotestosterone (DHT), due to the 5α-reductase activity. The BPH therapeutic approach mainly uses 5α-reductase inhibitors, such as the active compounds present in the extracts deriving from species Serenoa repens. Many lipidosterolic extracts are available on the market, which are obtained with different solvents, among them ethanol is recognized as non-toxic and has less handling risks than hexane. The purpose of the present experimental study was to investigate in-vitro the potency of an ethanol extract of S. repens comparing it with an n-hexane one. Materials and methods. Two different lipido-sterolic extracts of S. repens have been tested: ethanol extract and n-hexane extract, two batches for each one. The inhibitory action of the extract was evaluated estimating in-vitro the activity of enzyme 5α-reductase type I (5α-RI), which was mainly active under the experimental condition of pH 7.5. DHT amount, synthesized from testosterone (1 μM), was evaluated in a co-culture model of epithelial cells and fibroblasts resulting from prostatic biopsy of a patient with BPH.Results. The analysis of the resulting dose-response curves showed that the entire S. repens extracts inhibited the 5α-RI showing no difference between the two kinds of extract or between the batches. The resulting IC50 values were the following: 8.809 (95% CI = 5.133-15.56) and 9.464 (95% CI = 5.094- 18.27) for ethanol extracts; 11.08 (95% CI = 6.389-19.98) and 12.72 (95% CI = 7.758-21.53) for n-hexane extracts. Conclusions. The potency of ethanol extracts of S. repens was comparable with the one of n-hexane extracts.

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Section: Original Papermentioning

confidence: 99%