2018
DOI: 10.4081/aiua.2018.3.199
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Serenoa repens extracts: In vitro study of the 5α-reductase activity in a co-culture model for Benign Prostatic Hyperplasia

Abstract: Objectives. Benign Prostatic Hyperplasia (BPH) is a form of benign tumor that occurs in humans mainly with ageing. It affects more than 50% of over 50 years old males and it is characterized by an increased synthesis of dihydrotestosterone (DHT), due to the 5α-reductase activity. The BPH therapeutic approach mainly uses 5α-reductase inhibitors, such as the active compounds present in the extracts deriving from species Serenoa repens. Many lipidosterolic extracts are available on the market, which are obtained … Show more

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Cited by 8 publications
(6 citation statements)
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References 18 publications
(25 reference statements)
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“…Although the exact action of SR is not yet completely understood, several mechanisms have been proposed [8]. In particular, the presence of fatty acids and phytosterols has been hypothesized to confer upon SR an anti-inflammatory and antiproliferative action on prostatic tissue [9]. However, the heterogeneity of the previous reports and the different ways of SR extraction have still restrained any accurate understanding of the effectiveness of SR itself as well as compared with alpha-blockers [10].…”
Section: Discussionmentioning
confidence: 99%
“…Although the exact action of SR is not yet completely understood, several mechanisms have been proposed [8]. In particular, the presence of fatty acids and phytosterols has been hypothesized to confer upon SR an anti-inflammatory and antiproliferative action on prostatic tissue [9]. However, the heterogeneity of the previous reports and the different ways of SR extraction have still restrained any accurate understanding of the effectiveness of SR itself as well as compared with alpha-blockers [10].…”
Section: Discussionmentioning
confidence: 99%
“…The potential mechanisms by which LSESr affects these cellular processes and mitigates LUTS continue to be studied [22]. Studies have provided evidence that prostate cells preferentially take up free fatty acids, including those contained within LSESr [23][24][25].…”
Section: Moa Of Lsesr For the Treatment Of Lutsmentioning
confidence: 99%
“…Studies have provided evidence that prostate cells preferentially take up free fatty acids, including those contained within LSESr [23][24][25]. Once fatty acids are incorporated into the nuclear membrane, they can alter membrane fluidity, inducing temporary conformational changes to the 5-AR protein structure that can disrupt the conversion of testosterone to DHT [22,23,[26][27][28][29]. This form of non-competitive, reversible inhibition is hypothesized to reduce DHT-dependent androgen signaling, resulting in increased prostate cell apoptosis and decreased prostate cell proliferation and, subsequently, slowed prostate growth [15,22,26,27,29].…”
Section: Moa Of Lsesr For the Treatment Of Lutsmentioning
confidence: 99%
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“…11 In addition to declining estrogen levels in relationship to androgens, 11 other significant changes which affect the hair follicle specifically through and after menopause include: increased oxidative stress and inflammation, 19 stress-related increases in cortisol, 20,21 metabolic changes, 22 and changes in nutritional status. 23 One key ingredient is saw palmetto, which has shown efficacy in hair loss, 24,25 and is known for its well-documented antiandrogenic and DHT-inhibiting 26 properties. The dosage was optimized and increased in this formula.…”
Section: Jo00121mentioning
confidence: 99%