Dried Disc Technique for Determining Sensitivity to the Antibiotics

Thompson, B. A.

doi:10.1136/jcp.3.2.118

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…The Oxford cup method was still used in Norway early in the 1960s, but the two dominating methods were the tablet method and the paper disk method (Steen 1955). Paper disks had first been employed for assays of penicillin during World War II (Vincent and Vincent 1944), but the method was quickly adapted to the antibiotic susceptibility test (Thompson 1950). 4…”

Section: Sensitivity Testing: “A Necessary Evil”mentioning

confidence: 99%

Producing Standards, Producing the Nordic Region: Antibiotic Susceptibility Testing, from 1950–1970

Lie¹

2014

Sci Context

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ArgumentDuring the 1950s it became apparent that antibiotics could not conquer all microbes, and a series of tests were developed to assess the susceptibility of microbes to antibiotics. This article explores the development and standardization of one such testing procedure which became dominant in the Nordic region, and how the project eventually failed in the late 1970s. The standardization procedures amounted to a comprehensive scheme, standardizing not only the materials used, but also the methods and the interpretation of the results. Focusing on Sweden and Norway in particular, the article shows how this comprehensive standardization procedure accounted for several co-dependent factors and demanded collaboration within and across laboratories. Whereas literature on standardization has focused mostly on how facts and artefacts move within and across laboratories, I argue for the importance of also attending to regions and territories. More particularly, while arguing that the practices, ideals, and politics related to what have been called the "Nordic welfare state" were contributing to the design of the standardized procedure in the laboratory, I also argue that Scandinavia was drawn together as a unified region with and by these very same practices.

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Section: Sensitivity Testing: “A Necessary Evil”mentioning

confidence: 99%

Producing Standards, Producing the Nordic Region: Antibiotic Susceptibility Testing, from 1950–1970

Lie¹

2014

Sci Context

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“…At the outset filter paper strip methods were employed. During the course of time, however, this practice was abandoned in favour of the dried filter paper disc technique (Thompson, 1950;Fairbrother, Martyn, and Parker, 1951). When standard antibiotic test tablets (Evans's " sentests ") became available for most of the commoner drugs these were substituted for filter paper discs, since it was found that far more consistent and reliable results were thus obtained.…”

Section: Techniquementioning

confidence: 99%

The Sensitivity of Various Bacteria to Antibiotics During the Years 1951 to 1956

Giles¹,

Shuttleworth²

1958

J Clin Pathol

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“…At the Belgrave Hospital all the organisms isolated in the early cases were tested for chloramphenicol sensitivity by the disk method of Thompson (1950). This was soon abandoned, however, because in two cases a Proteus vulgaris isolated from each, which was apparently non-sensitive by the disk titration, vanished within 48 hours of treatment with the chloramphenicol solution.…”

Section: Bacteriologymentioning

confidence: 99%

Treatment of Chronic Otorrhoea with Chloramphenicol

Lewis¹,

Gray²

1951

BMJ

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The common causes of persistent ear discharge are chronic otitis media, chronic otitis externa, and infection in the cavities made by tympano-mastoidectomies and fenestration operations. It is difficult to assess the proportion of the population suffering from running ears, but Formby (1942) reported that just over 2% of recruits examined during the 1939-45 war were rejected because of chronic ear diseases. Otorrhoea formed the bulk of the cases. Johnston (1948) found that of 1,902 factory employees 3.3 % had suppurating middle ears, and Asherson (1950) states that 1 % of the school population of London in 1932 were treated for chronic otorrhoea.

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Dried Disc Technique for Determining Sensitivity to the Antibiotics

Cited by 11 publications

References 3 publications

Producing Standards, Producing the Nordic Region: Antibiotic Susceptibility Testing, from 1950–1970

Producing Standards, Producing the Nordic Region: Antibiotic Susceptibility Testing, from 1950–1970

The Sensitivity of Various Bacteria to Antibiotics During the Years 1951 to 1956

Treatment of Chronic Otorrhoea with Chloramphenicol

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