Dreidimensionale (3D) Histologie im Routineverfahren: praktische Durchführung und deren Evaluation

Éberlé, F.; Kanyildiz, Mukaddes; Schnabl, Saskia Maria; Schulz, Claudia; Häfner, Hans‐Martin; Adam, Patrick; Breuninger, Helmut

doi:10.1111/ddg.12466_suppl

Cited by 31 publications

(1 citation statement)

References 33 publications

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“…2D tissue sections of only a few micrometers thick of samples that can easily be larger than 10 mm can result in missing infection-indicating information, especially given the complexity and heterogenous make-up of IE biofilms. 3D histology techniques are in development and show histopathological promise ( Eberle et al, 2014 ), though have yet to be evaluated for IE.…”

Section: Investigative Research Approachesmentioning

confidence: 99%

Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies

Kouijzer

Noordermeer²,

Leeuwen³

et al. 2022

Front. Cell Dev. Biol.

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Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is increasing and mortality has not significantly improved despite technological advances. This review provides an updated overview using recent literature on the clinical presentation, diagnosis, imaging, causative pathogens, treatment, and outcomes in native valve, prosthetic valve, and cardiac device-related IE. In addition, the experimental approaches used in IE research to improve the understanding of disease mechanisms and the current diagnostic pipelines are discussed, as well as potential innovative diagnostic and therapeutic strategies. This will ultimately help towards deriving better diagnostic tools and treatments to improve IE patient outcomes.

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Section: Investigative Research Approachesmentioning

confidence: 99%

Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies

Kouijzer

Noordermeer²,

Leeuwen³

et al. 2022

Front. Cell Dev. Biol.

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Histology as a paradigm for a science‐based learning experience: Visits by histology education spirits of past, present, and future

Hortsch

2022

Anatomical Sciences Ed

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The term “histology” was coined a little over 200 years ago and the subject has always relied on microscopy as its defining technology. Microscopy was and still is an essential approach for the description of cellular components and their arrangements in living organisms. For more than a century and a half, histology or microanatomy has also been part of the basic science education for biomedical students. Traditionally, it has been taught in two major components, a didactic transfer of information, either in a lecture or self‐learning format, and in active‐learning laboratory sessions. These two modes of histology instruction conform with the dual‐processing theory of learning, one being more automatic and depending mainly on rote memorization, whereas the other is analytical, requiring more advanced reasoning skills. However, these two components of histology education are not separate and independent, but rather complementary and part of a multi‐step learning process that encourages a scientific analysis of visual information and involves higher‐level learning skills. Conventional, as well as modern electronic instruction methods (e‐learning) have been used in complementary ways to support the integrated succession of individual learning steps as outlined in this manuscript. However, as recent curricular reforms have curtailed instructional time, this traditional format of teaching histology is no longer sustainable and a reflective reassessment of the role of histology in modern biomedical education is a timely necessity.

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Virtual Microscopy Goes Global: The Images Are Virtual and the Problems Are Real

Hortsch,

Koney,

Oommen

et al. 2023

Advances in Experimental Medicine and Biology

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Dreidimensionale (3D) Histologie im Routineverfahren: praktische Durchführung und deren Evaluation

Cited by 31 publications

References 33 publications

Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies

Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies

Histology as a paradigm for a science‐based learning experience: Visits by histology education spirits of past, present, and future

Virtual Microscopy Goes Global: The Images Are Virtual and the Problems Are Real

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